A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. [PDF]
PLoS ONE, 2010 BackgroundViruses have evolved to evade the host's complement system. The open reading frames 4 (ORF4) of gammaherpesviruses encode homologs of regulators of complement activation (RCA) proteins, which inhibit complement activation at the level of C3 and
Beatrix Steer +4 more
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Differential activation of human neutrophils by SARS-CoV-2 variants of concern
Frontiers in Immunology, 2022 The emerging SARS-CoV-2 virus has affected the entire world with over 600 million confirmed cases and 6.5 million deaths as of September 2022. Since the beginning of the pandemic, several variants of SARS-CoV-2 have emerged, with different infectivity ...
Samuel Lebourgeois +19 more
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A Mechanism for the Activation of the Influenza Virus Transcriptase [PDF]
Molecular Cell, 2018 Influenza virus RNA polymerase (FluPol), a heterotrimer composed of PB1, PB2, and PA subunits (P3 in influenza C), performs both transcription and replication of the viral RNA genome. For transcription, FluPol interacts with the C-terminal domain (CTD) of RNA polymerase II (Pol II), which enables FluPol to snatch capped RNA primers from nascent host ...
Serna Martin, I +7 more
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The virion host shut-off (vhs) protein blocks a TLR-independent pathway of herpes simplex virus type 1 recognition in human and mouse dendritic cells. [PDF]
PLoS ONE, 2010 Molecular pathways underlying the activation of dendritic cells (DCs) in response to Herpes Simplex Virus type 1 (HSV-1) are poorly understood. Removal of the HSV virion host shut-off (vhs) protein relieves a block to DC activation observed during wild ...
Christopher R Cotter +5 more
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Azapropellanes with Anti-Influenza A Virus Activity [PDF]
ACS Medicinal Chemistry Letters, 2014 The synthesis of several [4,4,3], [4,3,3], and [3,3,3]azapropellanes is reported. Several of the novel amines displayed low-micromolar activities against an amantadine-resistant H1N1 strain, but they did not show activity against an amantadine-sensitive H3N2 strain. None of the tested compounds inhibit the influenza A/M2 proton channel function.
E. Torres +7 more
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Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication. [PDF]
PLoS Pathogens, 2017 Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility.
Sharon K Kuss-Duerkop +13 more
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Mast Cells Modulate Antigen-Specific CD8+ T Cell Activation During LCMV Infection
Frontiers in Immunology, 2021 Mast cells (MCs), strategically localized at mucosal surfaces, provide first-line defense against pathogens and shape innate and adaptive immune responses.
Yana Hackler +6 more
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Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome
Frontiers in Immunology, 2020 Dengue is the most prevalent and rapidly transmitted mosquito-borne viral disease of humans. One of the fundamental innate immune responses to viral infections includes the processing and release of pro-inflammatory cytokines such as interleukin (IL-1β ...
Gaurav Shrivastava +8 more
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Gamma-irradiated influenza virus uniquely induces IFN-I mediated lymphocyte activation independent of the TLR7/MyD88 pathway. [PDF]
PLoS ONE, 2011 BACKGROUND: We have shown previously in mice, that infection with live viruses, including influenza/A and Semliki Forest virus (SFV), induces systemic partial activation of lymphocytes, characterized by cell surface expression of CD69 and CD86, but not ...
Yoichi Furuya +8 more
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Virus Inhibitory Activity of Polyvinylamine.
Experimental Biology and Medicine, 1954 SummaryA comparative study of the virus inhibitory efficacy of the synthetic basic polypeptide, polylysine, and the synthetic basic polymer, polyvinylamine, revealed that both polymers inhibited the production of influenza B virus in the chick embryo.
M, GREEN, M A, STAHMANN
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