Results 11 to 20 of about 615,631 (266)
Polymerase Activity of Pichinde Virus [PDF]
Journal of Virology, 1974 Pichinde virus, a member of the arenavirus group, was examined for polymerase activity. Purified virus was found to contain RNA-dependent RNA polymerase but not RNA-dependent DNA polymerase activity. Since RNase but neither DNase nor actinomycin D inhibited the endogenous polymerase reaction, RNA of the virus appeared to be used as the ...
M F, Carter, N, Biswal, W E, Rawls
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Influenza virus activation of the interferon system. [PDF]
Virus Res, 2015 The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system.
Killip MJ, Fodor E, Randall RE.
europepmc +6 more sources
REVIVED ACTIVITY OF THE VIRUS OF POLIOMYELITIS [PDF]
Journal of Experimental Medicine, 1924 A strain of the virus of poliomyelitis has been described which has passed through several stages of virulence as tested upon monkeys. The first stage consisted of the adaptation of the original human virus to the monkey. In this process high virulence was readily achieved.
S, Flexner, H L, Amoss
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Evidence for Ebola Virus Superantigen Activity [PDF]
Journal of Virology, 2011 Zaire Ebola virus (ZEBOV) is the most lethal Ebola virus species and one of the most virulent human pathogens, causing a severe hemorrhagic fever syndrome that ends in the death of 90% of symptomatic patients within a few days (11). ZEBOV caused numerous human outbreaks in Central Africa between 1976 and 2008 and also devastated wild populations of ...
Leroy, Eric +3 more
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A Mechanism for the Activation of the Influenza Virus Transcriptase [PDF]
Molecular Cell, 2018 Influenza virus RNA polymerase (FluPol), a heterotrimer composed of PB1, PB2, and PA subunits (P3 in influenza C), performs both transcription and replication of the viral RNA genome. For transcription, FluPol interacts with the C-terminal domain (CTD) of RNA polymerase II (Pol II), which enables FluPol to snatch capped RNA primers from nascent host ...
Serna Martin, I +7 more
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Azapropellanes with Anti-Influenza A Virus Activity [PDF]
ACS Medicinal Chemistry Letters, 2014 The synthesis of several [4,4,3], [4,3,3], and [3,3,3]azapropellanes is reported. Several of the novel amines displayed low-micromolar activities against an amantadine-resistant H1N1 strain, but they did not show activity against an amantadine-sensitive H3N2 strain. None of the tested compounds inhibit the influenza A/M2 proton channel function.
E. Torres +7 more
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Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome
Frontiers in Immunology, 2020 Dengue is the most prevalent and rapidly transmitted mosquito-borne viral disease of humans. One of the fundamental innate immune responses to viral infections includes the processing and release of pro-inflammatory cytokines such as interleukin (IL-1β ...
Gaurav Shrivastava +8 more
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Gamma-irradiated influenza virus uniquely induces IFN-I mediated lymphocyte activation independent of the TLR7/MyD88 pathway. [PDF]
PLoS ONE, 2011 BACKGROUND: We have shown previously in mice, that infection with live viruses, including influenza/A and Semliki Forest virus (SFV), induces systemic partial activation of lymphocytes, characterized by cell surface expression of CD69 and CD86, but not ...
Yoichi Furuya +8 more
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A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier [PDF]
Clinical and Molecular Hepatology, 2012 Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended.
Joong Ho Bae +8 more
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Virus Inhibitory Activity of Polyvinylamine.
Experimental Biology and Medicine, 1954 SummaryA comparative study of the virus inhibitory efficacy of the synthetic basic polypeptide, polylysine, and the synthetic basic polymer, polyvinylamine, revealed that both polymers inhibited the production of influenza B virus in the chick embryo.
M, GREEN, M A, STAHMANN
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