Results 31 to 40 of about 646,497 (314)

Resting regulatory CD4 T cells: a site of HIV persistence in patients on long-term effective antiretroviral therapy. [PDF]

PLoS ONE, 2008
BACKGROUND: In HIV-infected patients on long-term HAART, virus persistence in resting long-lived CD4 T cells is a major barrier to curing the infection.
Tu-Anh Tran, Marie-Ghislaine de Goër de Herve, Houria Hendel-Chavez, Bamory Dembele, Emilie Le Névot, Karim Abbed, Coralie Pallier, Cécile Goujard, Jacques Gasnault, Jean-François Delfraissy, Anne-Marie Balazuc, Yassine Taoufik   +11 more
doaj   +1 more source

Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction [PDF]

, 2013
This work was supported by The Wellcome Trust (087751/A/08/Z).Preparations of parainfluenza virus 5 (PIV5) that are potent activators of the interferon (IFN) induction cascade were generated by high-multiplicity passage in order to accumulate defective ...
Killip, M. J., Davison, A. J., Young, D.F., Goodbourn, S., Ross, C.S., Young, D. F., Davison, A.J., Short, J.A.L., Ross, C. S., Randall, R. E., Gatherer, D., Short, J. A. L., Killip, M.J., Randall, R.E.   +13 more
core   +1 more source

Inter-domain communication in SARS-CoV-2 spike proteins controls protease-triggered cell entry

Cell Reports, 2022
Summary: SARS-CoV-2 continues to evolve into variants of concern (VOC), with greatest variability in the multidomain, entry-facilitating spike proteins. To recognize the significance of adaptive spike protein changes, we compare variant SARS-CoV-2 virus ...
Enya Qing, Pengfei Li, Laura Cooper, Sebastian Schulz, Hans-Martin Jäck, Lijun Rong, Stanley Perlman, Tom Gallagher   +7 more
doaj   +1 more source

Epstein-Barr Virus LF2: an Antagonist to Type 1 Interferon [PDF]

, 2009
Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway, which is mediated by IFN regulatory factors (IRFs).
Shin, Young Chul, Johannsen, Eric, Haas, Juergen, Hyun Joo, Chul, Fossum, Even, Hutt-Fletcher, Lindsay M., Wu, L., Inn, Kyung-Soo, Jung, Jae U.   +8 more
core   +1 more source

Flavonoids as Molecules With Anti-Zika virus Activity [PDF]

Frontiers in Microbiology, 2021
Zika virus (ZIKV) is an arthropod-born virus that is mainly transmitted to humans by mosquitoes of the genus Aedes spp. Since its first isolation in 1947, only a few human cases had been described until large outbreaks occurred on Yap Island (2007), French Polynesia (2013), and Brazil (2015).
Depieri Cataneo, Allan Henrique, Pereira Ávila, Eloah, Albuquerque de Oliveira Mendes, Larissa, Guedes de Oliveira, Viviane, Rodrigues Ferraz, Camila, Vieira de Almeida, Mauro, Frabasile Giurato, Sandra Alicia, Nunes Duarte dos Santos, Claudia, Verri Jr, Waldiceu Aparecido, Bordignon, Juliano, Fanini Wowk, Pryscilla   +10 more
openaire   +4 more sources

Interferon-beta pretreatment of conventional and plasmacytoid human dendritic cells enhances their activation by influenza virus. [PDF]

PLoS Pathogens, 2008
Influenza virus produces a protein, NS1, that inhibits infected cells from releasing type I interferon (IFN) and blocks maturation of conventional dendritic cells (DCs).
Hannah Phipps-Yonas, Jeremy Seto, Stuart C Sealfon, Thomas M Moran, Ana Fernandez-Sesma   +4 more
doaj   +1 more source

Activation of One Plant Virus by Another

Nature, 1960
TOBACCO necrosis is a disease that can be caused by several serologically unrelated viruses1, all of which are soil-borne and cause necrotic local lesions in leaves of tobacco (Nicotiana tabacum L.) and French bean (Phaseolus vulgaris L.) plants. The virus Bawden and Pirie2,3 called the ‘Rothamsted culture’ differed in several respects from other ...
Kassanis, B., Nixon, H. L.
openaire   +2 more sources

Respiratory syncytial virus and neutrophil activation [PDF]

Clinical and Experimental Immunology, 2005
SummaryRespiratory syncytial virus infects almost all children by 2 years of age. Neutrophils are the predominant airway leucocytes in RSV bronchiolitis and they are activated in the presence of infection. However it is not clear whether RSV can directly signal to activate neutrophil cytotoxic function. To investigate this we have used a preparation of
E L, Bataki, G S, Evans, M L, Everard
openaire   +2 more sources

Endosymbiotic RNA virus inhibits Leishmania-induced caspase-11 activation

iScience, 2021
Summary: New World species of the intracellular protozoan parasites of the Leishmania genus can cause mucocutaneous leishmaniases. The presence of an endosymbiotic Leishmania RNA virus (LRV) in Leishmania guyanensis (L.g.) promotes disease exacerbation ...
Renan V.H. de Carvalho, Djalma S. Lima-Júnior, Caroline V. de Oliveira, Dario S. Zamboni   +3 more
doaj   +1 more source

Microassay for Sindbis virus and interferon activity [PDF]

Journal of Clinical Microbiology, 1983
A simple and rapid microplaque assay for Sindbis virus was developed which uses microtiter plates and overlay medium consisting of methylcellulose and specific antibody to Sindbis virus. Discrete plaque formation was consistently observed on baby hamster kidney (BHK-15) cells within 24 h. The assay was reproducible, quantitative, and had about the same
R E, Lloyd, D A, Weigent, G J, Stanton
openaire   +2 more sources