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Structure of SARS-CoV-2 membrane protein essential for virus assembly [PDF]
Nature Communications, 2022 M protein plays essential roles in virus assembly and morphogenesis. Here, authors reveal two cryo-EM structures of M protein from SARS-CoV-2 that suggest conformational dynamics of M protein and its role in virus assembly.
Zhikuan Zhang +13 more
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Identification of a pocket factor that is critical to Zika virus assembly. [PDF]
Nat Commun, 2020 Zika virus (ZIKV) is an emerging mosquito borne flavivirus and a major public health concern causing severe disease. Due to the presence of a lipid membrane and structural heterogeneity, attaining an atomic resolution structure is challenging, but ...
DiNunno NM +7 more
europepmc +2 more sources
Promotion of virus assembly and organization by the measles virus matrix protein
Nature Communications, 2018 Virus assembly is technically challenging to study. Here the authors use cryo-electron tomography of measles virus-infected human cells to determine native-state virus structure and they locate well-ordered M lattices that organize viral glycoproteins ...
Zunlong Ke +8 more
doaj +2 more sources
Zika Virus NS2A-Mediated Virion Assembly
mBio, 2019 The flavivirus virion consists of an envelope outer layer, formed by envelope (E) and membrane (M) proteins on a lipid bilayer, and an internal core, formed by capsid (C) protein and genomic RNA. The molecular mechanism of flavivirus assembly is not well
Xianwen Zhang +7 more
doaj +2 more sources
Chikungunya virus assembly and budding visualized in situ using cryogenic electron tomography. [PDF]
Nat Microbiol, 2022 Chmielewski D +4 more
europepmc +2 more sources
Frontiers in Microbiology, 2021 Flavivirus envelope protein (E) plays an important role in cellular infection, especially in virulence and antigenicity. E domain III of Tembusu virus (TMUV) is highly conserved among flaviviruses and contains four loop regions. However, the functions of
Tao Hu +50 more
doaj +1 more source
Rotavirus Particle Disassembly and Assembly In Vivo and In Vitro
Viruses, 2023 Rotaviruses (RVs) are non-enveloped multilayered dsRNA viruses that are major etiologic agents of diarrheal disease in humans and in the young in a large number of animal species.
Dunia Asensio-Cob +2 more
doaj +1 more source
Viruses, 2021 The assembly of a hexameric lattice of retroviral immature particles requires the involvement of cell factors such as proteins and small molecules. A small, negatively charged polyanionic molecule, myo-inositol hexaphosphate (IP6), was identified to ...
Alžběta Dostálková +5 more
doaj +1 more source
The curious case of genome packaging and assembly in RNA viruses infecting plants
Frontiers in Genetics, 2023 Genome packaging is the crucial step for maturation of plant viruses containing an RNA genome. Viruses exhibit a remarkable degree of packaging specificity, despite the probability of co-packaging cellular RNAs.
Tushar Ranjan +9 more
doaj +1 more source
Super-resolution microscopy reveals specific recruitment of HIV-1 envelope proteins to viral assembly sites dependent on the envelope C-terminal tail [PDF]
, 2013 The inner structural Gag proteins and the envelope (Env) glycoproteins of human immunodeficiency virus (HIV-1) traffic independently to the plasma membrane, where they assemble the nascent virion. HIV-1 carries a relatively low number of glycoproteins in
Heilemann, Mike +4 more
core +6 more sources