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Friend or Foe: The Role of the Cytoskeleton in Influenza A Virus Assembly [PDF]

Viruses, 2019
Influenza A Virus (IAV) is a respiratory virus that causes seasonal outbreaks annually and pandemics occasionally. The main targets of the virus are epithelial cells in the respiratory tract.
Sukhmani Bedi, Akira Ono
doaj   +2 more sources

Structure of SARS-CoV-2 membrane protein essential for virus assembly [PDF]

Nature Communications, 2022
M protein plays essential roles in virus assembly and morphogenesis. Here, authors reveal two cryo-EM structures of M protein from SARS-CoV-2 that suggest conformational dynamics of M protein and its role in virus assembly.
Zhikuan Zhang, Norimichi Nomura, Yukiko Muramoto, Toru Ekimoto, Tomoko Uemura, Kehong Liu, Moeko Yui, Nozomu Kono, Junken Aoki, Mitsunori Ikeguchi, Takeshi Noda, So Iwata, Umeharu Ohto, Toshiyuki Shimizu   +13 more
doaj   +2 more sources

Human Immunodeficiency Virus Type 1 Gag Polyprotein Modulates Membrane Physical Properties like a Surfactant: Potential Implications for Virus Assembly. [PDF]

ACS Infect Dis
Denieva ZG, Kuzmin PI, Galimzyanov TR, Datta SAK, Rein A, Batishchev OV.   +5 more
europepmc   +3 more sources

Substitutions at Loop Regions of TMUV E Protein Domain III Differentially Impair Viral Entry and Assembly

Frontiers in Microbiology, 2021
Flavivirus envelope protein (E) plays an important role in cellular infection, especially in virulence and antigenicity. E domain III of Tembusu virus (TMUV) is highly conserved among flaviviruses and contains four loop regions. However, the functions of
Tao Hu, Zhen Wu, Shaoxiong Wu, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Dekang Zhu, Dekang Zhu, Dekang Zhu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Juan Huang, Juan Huang, Juan Huang, Sai Mao, Sai Mao, Sai Mao, Xumin Ou, Xumin Ou, Xumin Ou, Qun Gao, Qun Gao, Qun Gao, Di Sun, Di Sun, Di Sun, Yunya Liu, Ling Zhang, YanLing Yu, Shun Chen, Shun Chen, Shun Chen, Anchun Cheng, Anchun Cheng, Anchun Cheng   +50 more
doaj   +1 more source

Rotavirus Particle Disassembly and Assembly In Vivo and In Vitro

Viruses, 2023
Rotaviruses (RVs) are non-enveloped multilayered dsRNA viruses that are major etiologic agents of diarrheal disease in humans and in the young in a large number of animal species.
Dunia Asensio-Cob, Javier M. Rodríguez, Daniel Luque   +2 more
doaj   +1 more source

Effect of Small Polyanions on In Vitro Assembly of Selected Members of Alpha-, Beta- and Gammaretroviruses

Viruses, 2021
The assembly of a hexameric lattice of retroviral immature particles requires the involvement of cell factors such as proteins and small molecules. A small, negatively charged polyanionic molecule, myo-inositol hexaphosphate (IP6), was identified to ...
Alžběta Dostálková, Barbora Vokatá, Filip Kaufman, Pavel Ulbrich, Tomáš Ruml, Michaela Rumlová   +5 more
doaj   +1 more source

Structural Assembly of Qβ Virion and Its Diverse Forms of Virus-like Particles

Viruses, 2022
The coat proteins (CPs) of single-stranded RNA bacteriophages (ssRNA phages) directly assemble around the genomic RNA (gRNA) to form a near-icosahedral capsid with a single maturation protein (Mat) that binds the gRNA and interacts with the retractile ...
Jeng-Yih Chang, Karl V. Gorzelnik, Jirapat Thongchol, Junjie Zhang   +3 more
doaj   +1 more source

Alphavirus Particles Can Assemble with an Alternate Triangulation Number

Viruses, 2022
Alphaviruses are spherical, enveloped RNA viruses primarily transmitted by mosquitoes, and cause significant arthritogenic and neurotropic disease in humans and livestock.
Jason T. Kaelber, David Chmielewski, Wah Chiu, Albert J. Auguste   +3 more
doaj   +1 more source

Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane

Viruses, 2020
Marburg virus (MARV) is a lipid-enveloped negative sense single stranded RNA virus, which can cause a deadly hemorrhagic fever. MARV encodes seven proteins, including VP40 (mVP40), a matrix protein that interacts with the cytoplasmic leaflet of the host ...
Kaveesha J. Wijesinghe, Luke McVeigh, Monica L. Husby, Nisha Bhattarai, Jia Ma, Bernard S. Gerstman, Prem P. Chapagain, Robert V. Stahelin   +7 more
doaj   +1 more source

Live Cell Imaging Reveals HBV Capsid Translocation from the Nucleus To the Cytoplasm Enabled by Cell Division

mBio, 2023
Hepatitis B virus (HBV) capsid assembly is traditionally thought to occur predominantly in the cytoplasm, where the virus gains access to the virion egress pathway.
Sofia Romero, Nuruddin Unchwaniwala, Edward L. Evans, Kevin W. Eliceiri, Daniel D. Loeb, Nathan M. Sherer   +5 more
doaj   +1 more source