Results 11 to 20 of about 6,218 (268)
Virus assembly, allostery and antivirals [PDF]
Trends in Microbiology, 2011 Assembly of virus capsids and surface proteins must be regulated to ensure that the resulting complex is an infectious virion. In this review, we examine assembly of virus capsids, focusing on hepatitis B virus and bacteriophage MS2, and formation of glycoproteins in the alphaviruses.
Adam Zlotnick, Suchetana Mukhopadhyay
openaire +3 more sources
CryoEM of Viral Ribonucleoproteins and Nucleocapsids of Single-Stranded RNA Viruses
Viruses, 2023 Single-stranded RNA viruses (ssRNAv) are characterized by their biological diversity and great adaptability to different hosts; traits which make them a major threat to human health due to their potential to cause zoonotic outbreaks.
Andrea Modrego +3 more
doaj +1 more source
Microbial Cell, 2016 Herpes simplex virus 1 (HSV-1) is a human pathogen that establishes latency in the nucleus of infected neurons in the PNS and the CNS. At the transcriptional level latency is characterized by a quasi-complete silencing of the extrachromosomal viral ...
Patrick Lomonte
doaj +1 more source
Cryo-EM structure in situ reveals a molecular switch that safeguards virus against genome loss
eLife, 2020 The portal protein is a key component of many double-stranded DNA viruses, governing capsid assembly and genome packaging. Twelve subunits of the portal protein define a tunnel, through which DNA is translocated into the capsid.
Oliver W Bayfield +2 more
doaj +1 more source
Biophysica, 2023 Virus particles consist of a protein coat that protects their genetic material and delivers it to the host cell for self-replication. Understanding the interplay between virus structure and function is a requirement for understanding critical processes ...
David Reguera +6 more
doaj +1 more source
Efficient support of virus-like particle assembly by the HIV-1 packaging signal
eLife, 2018 The principal structural component of a retrovirus particle is the Gag protein. Retroviral genomic RNAs contain a ‘packaging signal’ (‘Ψ') and are packaged in virus particles with very high selectivity.
Mauricio Comas-Garcia +5 more
doaj +1 more source
Human Cytomegalovirus Egress: Overcoming Barriers and Co-Opting Cellular Functions
Viruses, 2021 The assembly of human cytomegalovirus (HCMV) and other herpesviruses includes both nuclear and cytoplasmic phases. During the prolonged replication cycle of HCMV, the cell undergoes remarkable changes in cellular architecture that include marked ...
Veronica Sanchez, William Britt
doaj +1 more source
Cells, 2021 Coronaviruses (CoVs) assemble by budding into the lumen of the intermediate compartment (IC) at the endoplasmic reticulum (ER)-Golgi interface. However, why CoVs have chosen the IC as their intracellular site of assembly and how progeny viruses are ...
Jaakko Saraste, Kristian Prydz
doaj +1 more source
Advanced Materials Interfaces, EarlyView., 2023 This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi +4 more
wiley +1 more source
Pathogens, 2020 The insurgence of superresolution microscopy into the fields of virology and microbiology has begun to enable the mapping of molecular assemblies critical for host–pathogen interfaces that organize on a scale below the resolution limit of the light ...
Nicholas S. Groves +2 more
doaj +1 more source