Results 31 to 40 of about 3,262,736 (331)
Alterations of membrane curvature during influenza virus budding [PDF]
, 2014 Influenza A virus belongs to the Orthomyxoviridae family. It is an enveloped virus that contains a segmented and negative-sense RNA genome. Influenza A viruses cause annual epidemics and occasional major pandemics, are a major cause of morbidity and ...
Agnieszka Martyna +29 more
core +1 more source
A modelling paradigm for RNA virus assembly
Current Opinion in Virology, 2018 Highlights • Multiple, common dispersed packaging signals (PSs) promote RNA virus assembly.• PS-mediated assembly solves a viral equivalent of Levinthal’s Paradox.• RNA PSs occur in many viral families, including Picornaviruses and Hepatitis B virus ...
R. Twarock +3 more
semanticscholar +1 more source
Developmental Cell, 2020 Autophagy acts as a cellular surveillance mechanism to combat invading pathogens. Viruses have evolved various strategies to block autophagy and even subvert it for their replication and release.
Guangyan Miao +8 more
semanticscholar +1 more source
A new strategy for the treatment of viral infections [PDF]
, 2006 Intact viruses, containing no viral genome but which are loaded with a therapeutic drug or virus like particles loaded with antiviral drugs are potentially selective drug carriers for the intracellular delivery of therapeutics.
Wolf, Markus
core +1 more source
Scientific Reports, 2018 Monitoring virus assembly at the nanoscale in host cells remains a major challenge. Human immunodeficiency virus type 1 (HIV-1) components are addressed to the plasma membrane where they assemble to form spherical particles of 100 nm in diameter ...
Charlotte Floderer +10 more
semanticscholar +1 more source
Dual Role of a Viral Polymerase in Viral Genome Replication and Particle Self-Assembly
mBio, 2018 Double-stranded RNA (dsRNA) viruses package several RNA-dependent RNA polymerases (RdRp) together with their dsRNA genome into an icosahedral protein capsid known as the polymerase complex.
Xiaoyu Sun +3 more
doaj +1 more source
A role for domain I of the hepatitis C virus NS5A protein in virus assembly
PLoS Pathogens, 2018 The NS5A protein of hepatitis C virus (HCV) plays roles in both virus genome replication and assembly. NS5A comprises three domains, of these domain I is believed to be involved exclusively in genome replication.
Chunhong Yin +3 more
semanticscholar +1 more source
mBio, 2018 The assembly of virus particles is a crucial aspect of virus spread. For retroviruses, the Gag polyprotein is the key driver for virus particle assembly.
John P. Eichorst +3 more
doaj +1 more source
Human Cytomegalovirus Egress: Overcoming Barriers and Co-Opting Cellular Functions
Viruses, 2021 The assembly of human cytomegalovirus (HCMV) and other herpesviruses includes both nuclear and cytoplasmic phases. During the prolonged replication cycle of HCMV, the cell undergoes remarkable changes in cellular architecture that include marked ...
Veronica Sanchez, William Britt
doaj +1 more source
Virus assembly, allostery and antivirals [PDF]
Trends in Microbiology, 2011 Assembly of virus capsids and surface proteins must be regulated to ensure that the resulting complex is an infectious virion. In this review, we examine assembly of virus capsids, focusing on hepatitis B virus and bacteriophage MS2, and formation of glycoproteins in the alphaviruses.
Zlotnick, Adam, Mukhopadhyay, Suchetana
openaire +2 more sources