Results 31 to 40 of about 6,218 (268)
Hepatitis C Virus: Assembly and Release of Virus Particles [PDF]
Journal of Biological Chemistry, 2010 Hepatitis C virus is a blood-borne virus that typically establishes a chronic infection in the liver, which often results in cirrhosis and hepatocellular carcinoma. Progress in understanding the complete virus life cycle has been greatly enhanced by the recent availability of a tissue culture system that produces infectious virus progeny.
Daniel M. Jones, John McLauchlan
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Promotion of virus assembly and organization by the measles virus matrix protein
Nature Communications, 2018 Virus assembly is technically challenging to study. Here the authors use cryo-electron tomography of measles virus-infected human cells to determine native-state virus structure and they locate well-ordered M lattices that organize viral glycoproteins ...
Zunlong Ke +8 more
doaj +1 more source
Distinct Morphology of Human T-Cell Leukemia Virus Type 1-Like Particles
Viruses, 2016 The Gag polyprotein is the main retroviral structural protein and is essential for the assembly and release of virus particles. In this study, we have analyzed the morphology and Gag stoichiometry of human T-cell leukemia virus type 1 (HTLV-1)-like ...
José O. Maldonado +3 more
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Modelling the self-assembly of virus capsids [PDF]
Journal of Physics: Condensed Matter, 2010 We use computer simulations to study a model, first proposed by Wales [1], for the reversible and monodisperse self-assembly of simple icosahedral virus capsid structures. The success and efficiency of assembly as a function of thermodynamic and geometric factors can be qualitatively related to the potential energy landscape structure of the assembling
Johnston, I, Louis, A, Doye, J
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Friend or Foe: The Role of the Cytoskeleton in Influenza A Virus Assembly
Viruses, 2019 Influenza A Virus (IAV) is a respiratory virus that causes seasonal outbreaks annually and pandemics occasionally. The main targets of the virus are epithelial cells in the respiratory tract.
Sukhmani Bedi, Akira Ono
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A modelling paradigm for RNA virus assembly [PDF]
Current Opinion in Virology, 2018 Virus assembly, a key stage in any viral life cycle, had long been considered to be primarily driven by protein-protein interactions and nonspecific interactions between genomic RNA and capsid protein. We review here a modelling paradigm for RNA virus assembly that illustrates the crucial roles of multiple dispersed, specific interactions between viral
Twarock, Reidun +3 more
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On the Selective Packaging of Genomic RNA by HIV-1
Viruses, 2016 Like other retroviruses, human immunodeficiency virus type 1 (HIV-1) selectively packages genomic RNA (gRNA) during virus assembly. However, in the absence of the gRNA, cellular messenger RNAs (mRNAs) are packaged.
Mauricio Comas-Garcia +2 more
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The Morphology and Assembly of Respiratory Syncytial Virus Revealed by Cryo-Electron Tomography
Viruses, 2018 Human respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract disease in young children. With repeat infections throughout life, it can also cause substantial disease in the elderly and in adults with compromised cardiac ...
Zunlong Ke +18 more
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mBio, 2023 Hepatitis B virus (HBV) capsid assembly is traditionally thought to occur predominantly in the cytoplasm, where the virus gains access to the virion egress pathway.
Sofia Romero +5 more
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Bluetongue Virus Capsid Assembly and Maturation [PDF]
Viruses, 2014 Maturation is an intrinsic phase of the viral life cycle and is often intertwined with egress. In this review we focus on orbivirus maturation by using Bluetongue virus (BTV) as a representative. BTV, a member of the genus Orbivirus within the family Reoviridae, has over the last three decades been subjected to intense molecular study and is thus one ...
Polly Roy, Bjorn-Patrick Mohl
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