Results 61 to 70 of about 124,032 (305)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Reporte de casos por infección de virus de Influenza A H1N1: Hallazgos de autopsia

Revista de Ciencias Forenses de Honduras, 2018
La influenza continúa siendo una causa importante de muerte en las Américas; en nuestro país al igual que en otros países del continente, hay circulación viral sostenida del virus Influenza H1N1pdm09, este reporte describe los hallazgos histopatológicos
Enoe Arely Vásquez, Mireya Matamoros, Nicolás Sabillón   +2 more
doaj   +1 more source

Patrón de alteraciones en la radiografía de tórax de niños hospitalizados por infección causada por virus influenza A (H1N1) [PDF]

Revista chilena de enfermedades respiratorias, 2010
El ano 2009 aparecieron los primeros casos de influenza humana causada por virus influenza A H1N1, propagandose como pandemia. En nuestra institucion se observo 88,5% de aumento en consultas de urgencia, adultos y ninos; se diagnosticaron 10.048 pacientes como influenza A H1N1 (45,6% confirmacion de laboratorio). La media de edad fue 13 anos.
MOËNNE B, KARLA, ORTEGA F, XIMENA, CORDERO T, JAIME, VIDAL G, ALBERTO, ESCAFFI J, JUAN A   +4 more
openaire   +2 more sources

Demostren certa immunitat del porc front el virus humà H1N1 [PDF]

, 2010
Un grup d'investigadors del CReSA ha elaborat un estudi per conèixer l'abast del virus humà H1N1 en porcs prèviament infectats per virus circulants de la grip porcina.
Montoya González, Maria
core   +1 more source

Respiratory antiviral immunity and immunobiotics: Beneficial effects on inflammation-coagulation interaction during influenza virus infection [PDF]

, 2016
Influenza virus (IFV) is a major respiratory pathogen of global importance, and the cause of a high degree of morbidity and mortality, especially in high-risk populations such as infants, elderly, and immunocompromised hosts.
Alvarez, Gladis Susana, Kitazawa, Haruki, Villena, Julio Cesar, Zelaya, María Hortensia del Rosario   +3 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Neumonía por virus de la influenza A H1N1 en un adolescente Pneumonia due to A H1N1 influenza virus in an adolescent

Medisan, 2010
Se presenta el primer caso clínico de un adolescente de 11 años de edad, ingresado en la Unidad de Cuidados Progresivos del Hospital Infantil Norte "Dr. Juan de la Cruz Martínez Maceira" de Santiago de Cuba por presentar, desde hacía 4 días, malestar general, fiebre, tos, dolor en la garganta y falta de aire. Se diagnosticó una neumonía adquirida en la
Heriberto Arencibia Sosa, Alina Rubal Wong, Amarilis Dager Haber, Teresa Joa Mesa, Elisa Juy Aguirre   +4 more
openaire   +1 more source

Human annexin A6 interacts with influenza a virus protein M2 and negatively modulates infection [PDF]

, 2011
Copyright © 2012, American Society for Microbiology. All Rights ReservedThe influenza A virus M2 ion channel protein has the longest cytoplasmic tail (CT) among the three viral envelope proteins and is well conserved between different viral strains.
B. Nal, Barman, Barman, Bruce, Carlton, Chen, Chen, Chen, Cheung, Ciampor, Compans, Creutz, Cubells, Eierhoff, Enrich, F. Kien, Formstecher, Fromont-Racine, Gannagé, Gerke, Goswami, Grantham, Guan, Gujuluva, H. Ma, Harris, Hartshorn, Henkel, Hoffmann, Holsinger, Honda, Hui, Ichinohe, Iwatsuki-Horimoto, K. S. Tse, L. L. M. Poon, Lakadamyali, Lamb, Lamb, Lee, Li, Liu, M. Maniere, McCown, McCown, Monastyrskaya, N. Lagarde, Nayak, Nefkens, Noton, Palese, Pinto, Pinto, Pinto, Pleschka, Rossman, Rossman, Rossman, Scheiffele, Simpson-Holley, Smythe, Sun, Thaa, Thomas, Ueda, Vila de Muga, Wang, Wang, Welsch, Y. Zhang   +69 more
core   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source