Results 91 to 100 of about 263,373 (311)

Meta-transcriptomics reveals potential virus transfer between Aedes communis mosquitoes and their parasitic water mites

, 2022
Arthropods harbor a largely undocumented diversity of RNA viruses. Some arthropods, like mosquitoes, can transmit viruses to vertebrates but are themselves parasitized by other arthropod species, such as mites.
HOLMES, Edward, Ortiz-Baez, Ayda Susana,, Hesson, Jenny C., Holmes, Edward C, Charon, Justine, Charon, Justine,, Ortiz-Baez, Ayda Susana, Holmes, Edward C., Holmes, Edward C.,, Hesson, Jenny C.,, HESSON, Jenny, Pettersson, John, Hesson, Jenny C, Pettersson, John,, Pettersson, John H-O   +14 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Microbial diversity and the “lower-limit” problem of biodiversity [PDF]

, 2013
Science is now studying biodiversity on a massive scale. These studies are occurring not just at the scale of larger plants and animals, but also at the scale of minute entities such as bacteria and viruses. This expansion has led to the development of a
Malaterre, Christophe
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Diversity, distribution and comparative genomics of Microviridae in Sphagnum-peat soils

Frontiers in Microbiology, 2015
Microviridae, a family of bacteria-infecting ssDNA viruses, is a member of the still poorly characterized bacteriophages, even though they include phage PhiX174, one of the main models in virology for genomic and capsid structure studies.
Achim eQuaiser, Alexis eDufresne, Flore eBallaud, Simon eRoux, Yvan eZivanovic, Jonathan eColombet, Télesphore eSIME-NGANDO, Andre-Jean eFrancez   +7 more
doaj   +1 more source

Selection of neutralizing antibody escape mutants with type A influenza virus HA-specific polyclonal antisera: possible significance for antigenic drift [PDF]

, 1997
Ten antisera were produced in rabbits by two or three intravenous injections of inactivated whole influenza type A virions. All contained haemagglutination-inhibition (HI) antibody directed predominantly to an epitope in antigenic site B and, in addition,
Cleveland, S. Matthew, Dimmock, N. J., Taylor, H. P.   +2 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Quantifying influenza virus diversity and transmission in humans [PDF]

Nature Genetics, 2016
Influenza A virus is characterized by high genetic diversity. However, most of what is known about influenza evolution has come from consensus sequences sampled at the epidemiological scale that only represent the dominant virus lineage within each infected host.
Sebra, R, Guan, Y, Rogers, MB, Lin, X, Twaddle, A, DePasse, JV, Song, T, Poon, LLM, Rosenfeld, R, Stockwell, TB, Wentworth, DE, Holmes, EC, Greenbaum, B, Peiris, JSM, Cowling, BJ, Ghedin, E, Zhou, B, Halpin, RA   +17 more
openaire   +4 more sources

Recombination confounds the early evolutionary history of human immunodeficiency virus type 1: Subtype G is a circulating recombinant form

, 2007
Human immunodeficiency virus type I (HIV-1) is classified in nine subtypes (A to D, F, G, H, J, and K), a number of subsubtypes, and several circulating recombinant forms (CRFs).
Vandamme, Anne-Mieke, Camacho, Ricardo, Lemey, Philippe, Vidal, Nicole, Rambaut, Andrew, Peeters, Martine, Abecasis, Ana B., de Oliveira, Tulio, Shapiro, Beth   +8 more
core   +1 more source

Hepatitis C virus evasion mechanisms from neutralizing antibodies [PDF]

, 2011
Hepatitis C virus (HCV) represents a major public health problem, affecting 3% of the world’s population. The majority of infected individuals develop chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma.
Angus, Allan G.N., Arvind H. Patel, Patel, Arvind H., Caterina Di Lorenzo, Allan G. N. Angus, Lorenzo, Caterina D.   +5 more
core   +1 more source