Results 101 to 110 of about 263,373 (311)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Tutorial Toolbox to Simplify Bioinformatics and Biostatistics Analyses of Microbial Omics Data in an Island Context

BioMedInformatics
Background: Bioinformatics is increasingly used in various scientific works. Large amounts of heterogeneous data are being generated these days. It is difficult to interpret and analyze these data effectively.
Isaure Quétel, Sourakhata Tirera, Damien Cazenave, Nina Allouch, Chloé Baum, Yann Reynaud, Degrâce Batantou Mabandza, Virginie Nerrière, Serge Vedy, Matthieu Pot, Sébastien Breurec, Anne Lavergne, Séverine Ferdinand, Vincent Guerlais, David Couvin   +14 more
doaj   +1 more source

Irreversible impact of chronic hepatitis C virus infection on human natural killer cell diversity [PDF]

, 2018
Diversity is crucial for the immune system to efficiently combat infections. Natural killer (NK) cells are innate cytotoxic lymphocytes that contribute to the control of viral infections.
Hengst, Julia, Wedemeyer, Heiner, Björkström, Niklas K, Benedikt Strunz, Heiner Wedemeyer, Wedemeyer, H, Niklas K. Björkström, Bjorkstrom, NK, Julia Hengst, Strunz, Benedikt, Strunz, B,, Hengst, J   +11 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Distantly Related Rotaviruses in Common Shrews, Germany, 2004–2014

Emerging Infectious Diseases, 2019
We screened samples from common shrews (Sorex araneus) collected in Germany during 2004–2014 and identified 3 genetically divergent rotaviruses. Virus protein 6 sequence similarities to prototype rotaviruses were low (64.5% rotavirus A, 50.1% rotavirus C
Reimar Johne, Simon H. Tausch, Josephine Grützke, Alexander Falkenhagen, Corinna Patzina-Mehling, Martin Beer, Dirk Höper, Rainer G. Ulrich   +7 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Virome Identification and Characterization of Fusarium sacchari and F. andiyazi: Causative Agents of Pokkah Boeng Disease in Sugarcane

Frontiers in Microbiology, 2020
Fusarium sacchari and Fusarium andiyazi are two devastating sugarcane pathogens that cause pokkah boeng disease (PBD) in China. RNA_Seq was conducted to identify mycoviruses in F. sacchari and F.
Ziting Yao, Ziting Yao, Chengwu Zou, Chengwu Zou, Na Peng, Na Peng, Yu Zhu, Yixue Bao, Yixue Bao, Qiujuan Zhou, Qiujuan Zhou, Qingfa Wu, Baoshan Chen, Baoshan Chen, Muqing Zhang, Muqing Zhang   +15 more
doaj   +1 more source

Human immunodeficiency virus type 1 clade B superinfection:Evidence for differential immune containment of distinct clade B strains [PDF]

, 2005
Sequential infection with different strains of human immunodeficiency virus type 1 (HIV-1) is a rarely identified phenomenon with important implications for immunopathogenesis and vaccine development.
Yang, Otto O, Jamieson, Beth D, Leigh Brown, AJ, Little, SJ, Smith, Davey M, Daar, Eric S, Brown, Andrew J Leigh, Yang, OO, Pitt, JA, Petropoulos, CJ, Richman, DD, Balamurugan, Arumugam, Richman, Douglas D, Petropoulos, Christos J, Little, Susan J, Balamurugan, A, Daar, ES, Jamieson, BD, Smith, DM, Pitt, Jacqueline A   +19 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Plant Virus Diversity and Evolution

, 2016
Historically, the majority of plant virology focused on agricultural systems. Recent efforts have expanded our knowledge of the true diversity of plant viruses by studying those viruses that infect wild, undomesticated plants. Those efforts have provided answers to basic ecological questions regarding viruses in the wild, and insights into evolutionary
Stobbe, Anthony, Roossinck, Marilyn J.
openaire   +1 more source