Results 51 to 60 of about 258,080 (265)

The Diverse Roles of microRNAs at the Host–Virus Interface [PDF]

Viruses, 2018
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Through this activity, they are implicated in almost every cellular process investigated to date. Hence, it is not surprising that miRNAs play diverse roles in regulation of viral infections and antiviral responses. Diverse families of DNA and
Annie Bernier, Selena M. Sagan
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Virome Characterization of a Collection of S. sclerotiorum from Australia

Frontiers in Microbiology, 2018
Sclerotinia sclerotiorum is a devastating plant pathogen that attacks numerous economically important broad acre and vegetable crops worldwide. Mycoviruses are widespread viruses that infect fungi, including S. sclerotiorum.
Fan Mu, Fan Mu, Jiatao Xie, Jiatao Xie, Shufen Cheng, Shufen Cheng, Ming Pei You, Martin J. Barbetti, Jichun Jia, Jichun Jia, Qianqian Wang, Qianqian Wang, Jiasen Cheng, Jiasen Cheng, Yanping Fu, Tao Chen, Daohong Jiang, Daohong Jiang   +17 more
doaj   +1 more source

Virus Prevalence and Genetic Diversity Across a Wild Bumblebee Community

Frontiers in Microbiology, 2021
Viruses are key population regulators, but we have limited knowledge of the diversity and ecology of viruses. This is even the case in wild host populations that provide ecosystem services, where small fitness effects may have major ecological impacts in
David J. Pascall, David J. Pascall, Matthew C. Tinsley, Bethany L. Clark, Bethany L. Clark, Darren J. Obbard, Lena Wilfert, Lena Wilfert   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

DIVERSITY OF HEPATITIS C VIRUS

The Professional Medical Journal, 2018
Objective: (1)To understand the diversity in HCV glycoprotein E1 and E2sequences at different stages of infection. (2) Method widely used in evolutionary studies of HIV,as a new gold standard in HCV research.Setting: Department of Biochemistry Sir Syed Institutest of Medical Sciences Karachi. Period. 1 Jan 2012 to 31 Dec 2012.
Hamid Mahmood, Nasir Zulfiqar, Sitara Hassan, Ammara Waqar, Naeem Shahzad, Irfan Faroqui   +5 more
openaire   +2 more sources

ViralZone: a knowledge resource to understand virus diversity [PDF]

Nucleic Acids Research, 2010
The molecular diversity of viruses complicates the interpretation of viral genomic and proteomic data. To make sense of viral gene functions, investigators must be familiar with the virus host range, replication cycle and virion structure. Our aim is to provide a comprehensive resource bridging together textbook knowledge with genomic and proteomic ...
Chantal Hulo, Edouard De Castro, Patrick Masson, Lydie Bougueleret, Amos Bairoch, Ioannis Xenarios, Philippe Le Mercier   +6 more
openaire   +4 more sources

Virome Identification and Characterization of Fusarium sacchari and F. andiyazi: Causative Agents of Pokkah Boeng Disease in Sugarcane

Frontiers in Microbiology, 2020
Fusarium sacchari and Fusarium andiyazi are two devastating sugarcane pathogens that cause pokkah boeng disease (PBD) in China. RNA_Seq was conducted to identify mycoviruses in F. sacchari and F.
Ziting Yao, Ziting Yao, Chengwu Zou, Chengwu Zou, Na Peng, Na Peng, Yu Zhu, Yixue Bao, Yixue Bao, Qiujuan Zhou, Qiujuan Zhou, Qingfa Wu, Baoshan Chen, Baoshan Chen, Muqing Zhang, Muqing Zhang   +15 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source