Results 61 to 70 of about 263,373 (311)

Comparative Proteomic Analysis of Huh7 Cells Transfected with Sub-Saharan African Hepatitis B Virus (Sub)genotypes Reveals Potential Oncogenic Factors

Viruses
In sub-Saharan Africa (SSA), the (sub)genotypes A1, D3, and E of the hepatitis B virus (HBV) prevail. Individuals infected with subgenotype A1 have a 4.5-fold increased risk of HCC compared to those infected with other (sub)genotypes.
Kiyasha Padarath, Aurélie Deroubaix, Previn Naicker, Stoyan Stoychev, Anna Kramvis   +4 more
doaj   +1 more source

Key Positions of HIV-1 Env and Signatures of Vaccine Efficacy Show Gradual Reduction of Population Founder Effects at the Clade and Regional Levels

mBio, 2020
HIV-1 group M was transmitted to humans nearly one century ago. The virus has since evolved to form distinct clades, which spread to different regions of the world.
Changze Han, Jacklyn Johnson, Rentian Dong, Raghavendranath Kandula, Alexa Kort, Maria Wong, Tianbao Yang, Patrick J. Breheny, Grant D. Brown, Hillel Haim   +9 more
doaj   +1 more source

Evolution of replication efficiency following infection with a molecularly cloned feline immunodeficiency virus of low virulence [PDF]

, 2002
The development of an effective vaccine against human immunodeficiency virus is considered to be the most practicable means of controlling the advancing global AIDS epidemic.
Hosie, M.J., Dunsford, T.H., Shimojima, M., Klein, D., Willett, B.J., Neil, J.C., Jarrett, O., Cannon, C.   +7 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Comparison of the Proteome of Huh7 Cells Transfected with Hepatitis B Virus Subgenotype A1, with or without G1862T

Current Issues in Molecular Biology
HBeAg is a non-structural, secreted protein of hepatitis B virus (HBV). Its p25 precursor is post-translationally modified in the endoplasmic reticulum.
Kiyasha Padarath, Aurélie Deroubaix, Previn Naicker, Stoyan Stoychev, Anna Kramvis   +4 more
doaj   +1 more source

Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus [PDF]

, 2011
H5N1 highly pathogenic avian influenza virus has been endemic in poultry in Egypt since 2008, notwithstanding the implementation of mass vaccination and culling of infected birds.
Arafa, Abdel, Temperton, Nigel J., Giovanni Cattoli, Alessandra Buratin, Mona Meherez Aly, Adelaide Milani, Cattoli, Giovanni, Milani, Adelaide, Zecchin, Bianca, Ilaria Capua, Capua, Ilaria, Eleonora Molesti, Bianca Zecchin, Abdel Arafa, Buratin, Alessandra, Aly, Mona Meherez, Temperton, Nigel, Meherez Aly, Mona, Nigel Temperton, Molesti, Eleonora   +19 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Diverse Roles of microRNAs at the Host–Virus Interface [PDF]

Viruses, 2018
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Through this activity, they are implicated in almost every cellular process investigated to date. Hence, it is not surprising that miRNAs play diverse roles in regulation of viral infections and antiviral responses. Diverse families of DNA and
Annie Bernier, Selena M. Sagan
openaire   +3 more sources

Distribution and diversity of Potato mop-top virus in Sweden [PDF]

, 2013
During the last decades, spraing disease caused by Potato mop-top virus (PMTV) has become a severe problem in the potato production throughout the Nordic countries.
Beuch, Ulrike
core  

Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome [PDF]

, 2010
Background: Detection of a retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), has recently been reported in 67% of patients with chronic fatigue syndrome. We have studied a total of 170 samples from chronic fatigue syndrome patients from
Kerr Jonathan R, Breuer, J, Groom, HC, Randal Edward, Makinson, Kerry, Frank M Mattes, Baptista, Sarah, Kerr, JR, Groom, Harriet C.T., Bishop Kate N, Boucherit, VC, Kate N Bishop, Gow, John W., Gow, JW, Stoye Jonathan P, Judith Breuer, Baptista, S, Virginie C Boucherit, Kerry Makinson, Randal, Edward, Groom Harriet CT, Gow John W, Makinson Kerry, Hagan Suzanne, Groom, HCT, Makinson, K, Bishop, KN, Baptista Sarah, Suzanne Hagan, Harriet CT Groom, John W Gow, Boucherit, Virginie C., Edward Randal, Breuer Judith, Boucherit Virginie C, Randal, E, Hagan, S, Jonathan R Kerr, Mattes, Frank M., Hagan, Suzanne; id_orcid, Stoye, JP, Mattes Frank M, Sarah Baptista, Jonathan P Stoye, Mattes, FM   +44 more
core   +1 more source