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Influenza Virus Entry inhibitors
2022Influenza is a major challenge to health and the global economy. However, the increasing emergence of drug resistance during influenza pandemics cannot be ignored. It is particularly important to design and develop anti-influenza drugs with novel mechanisms of action for the treatment and prevention of influenza virus infections.
Jie, Yang, Shuwen, Liu
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2022
Ebola virus (EBOV) is one of the most deadliest agents already known, causing periodic epidemic of a severe hemorrhagic fever disease in Africa. Although two monoclonal antibody (mAb) drugs have recently received approval in the USA, additional therapeutics are still needed to combat potential outbreaks of resistance variants and other closely related ...
Ruikun, Du +3 more
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Ebola virus (EBOV) is one of the most deadliest agents already known, causing periodic epidemic of a severe hemorrhagic fever disease in Africa. Although two monoclonal antibody (mAb) drugs have recently received approval in the USA, additional therapeutics are still needed to combat potential outbreaks of resistance variants and other closely related ...
Ruikun, Du +3 more
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Virus entry by macropinocytosis
Nature Cell Biology, 2009As obligatory intracellular parasites, viruses rely on host-cell functions for most aspects of their replication cycle. This is born out during entry, when most viruses that infect vertebrate and insect cells exploit the endocytic activities of the host cell to move into the cytoplasm.
Mercer J, Helenius A.
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Annual Review of Biochemistry, 2010
Although viruses are simple in structure and composition, their interactions with host cells are complex. Merely to gain entry, animal viruses make use of a repertoire of cellular processes that involve hundreds of cellular proteins. Although some viruses have the capacity to penetrate into the cytosol directly through the plasma membrane, most depend
Mercer J, Schelhaas M, Helenius A.
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Although viruses are simple in structure and composition, their interactions with host cells are complex. Merely to gain entry, animal viruses make use of a repertoire of cellular processes that involve hundreds of cellular proteins. Although some viruses have the capacity to penetrate into the cytosol directly through the plasma membrane, most depend
Mercer J, Schelhaas M, Helenius A.
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Influenza A Virus: Cellular Entry
2023The frequent emergence of pathogenic viruses with pandemic potential has posed a significant threat to human health and economy, despite enormous advances in our understanding of infection mechanisms and devising countermeasures through developing various prophylactic and therapeutic strategies. The recent coronavirus disease (COVID-19) pandemic has re-
Yasuyuki, Miyake +3 more
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2006
As a major pathogen of human and certain animal species, influenza virus causes wide spread and potentially devastating disease. To initiate infection, the virus first binds to cellular receptors comprising either -(2,3 ) or -(2,6) linked sialic acid. Recent advances in our understanding of the influenza virus receptor and viral host species involved ...
Xiangjie, Sun, Gary R, Whittaker
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As a major pathogen of human and certain animal species, influenza virus causes wide spread and potentially devastating disease. To initiate infection, the virus first binds to cellular receptors comprising either -(2,3 ) or -(2,6) linked sialic acid. Recent advances in our understanding of the influenza virus receptor and viral host species involved ...
Xiangjie, Sun, Gary R, Whittaker
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Nonenveloped Eukaryotic Virus Entry
2021The virus replication cycle initiates on cell entry, arguably the most crucial step for virus infection. Moreover, the type of cell infected frequently defines the tissue tropism shown by viruses and in consequence the pathology observed. It is also the first point at which virus replication can be blocked making it a focus for intervention strategies ...
Ian M. Jones, Polly Roy
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Hepatitis C virus entry: beyond receptors
Reviews in Medical Virology, 2012SUMMARYHCV is a blood‐borne pathogen that affects approximately 3% of the global population and leads to progressive liver disease. Recent advances have identified an essential role for host cell molecules: tetraspanin CD81, scavenger receptor B1 and the tight junction proteins claudin‐1 and occludin in HCV entry, suggesting a complex multi‐step ...
Luke W, Meredith +3 more
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Hepatitis C Virus Entry and Neutralization
Clinics in Liver Disease, 2008The processes of hepatitis C virus (HCV) entry and antibody-mediated neutralization are intimately linked. The high frequency of neutralizing antibodies (nAbs) that inhibit E2-CD81 interaction(s) suggests that this is a major target for the humoral immune response.
Zania, Stamataki +3 more
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Virus entry. Lassa virus entry requires a trigger-induced receptor switch.
Science (New York, N.Y.), 2014Lassa virus spreads from a rodent to humans and can lead to lethal hemorrhagic fever. Despite its broad tropism, chicken cells were reported 30 years ago to resist infection. We found that Lassa virus readily engaged its cell-surface receptor α-dystroglycan in avian cells, but virus entry in susceptible species involved a pH-dependent switch to an ...
Lucas T, Jae +12 more
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