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Nature Reviews Microbiology
Hepatitis B virus (HBV) entry is the initial step of viral infection, leading to the formation of covalently closed circular DNA, which is a molecular reservoir of viral persistence and a key obstacle for HBV cure. The restricted entry of HBV into specific cell types determines the nature of HBV, which has a narrow host range in tissues and species ...
Koichi Watashi, Watashi Koichi
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Hepatitis B virus (HBV) entry is the initial step of viral infection, leading to the formation of covalently closed circular DNA, which is a molecular reservoir of viral persistence and a key obstacle for HBV cure. The restricted entry of HBV into specific cell types determines the nature of HBV, which has a narrow host range in tissues and species ...
Koichi Watashi, Watashi Koichi
exaly +3 more sources
Virus entry by macropinocytosis
Nature Cell Biology, 2009As obligatory intracellular parasites, viruses rely on host-cell functions for most aspects of their replication cycle. This is born out during entry, when most viruses that infect vertebrate and insect cells exploit the endocytic activities of the host cell to move into the cytoplasm.
Mercer J, Helenius A.
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Influenza Virus Entry inhibitors
2022Influenza is a major challenge to health and the global economy. However, the increasing emergence of drug resistance during influenza pandemics cannot be ignored. It is particularly important to design and develop anti-influenza drugs with novel mechanisms of action for the treatment and prevention of influenza virus infections.
Jie, Yang, Shuwen, Liu
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Influenza A Virus: Cellular Entry
2023The frequent emergence of pathogenic viruses with pandemic potential has posed a significant threat to human health and economy, despite enormous advances in our understanding of infection mechanisms and devising countermeasures through developing various prophylactic and therapeutic strategies. The recent coronavirus disease (COVID-19) pandemic has re-
Yasuyuki, Miyake +3 more
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2022
Ebola virus (EBOV) is one of the most deadliest agents already known, causing periodic epidemic of a severe hemorrhagic fever disease in Africa. Although two monoclonal antibody (mAb) drugs have recently received approval in the USA, additional therapeutics are still needed to combat potential outbreaks of resistance variants and other closely related ...
Ruikun, Du +3 more
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Ebola virus (EBOV) is one of the most deadliest agents already known, causing periodic epidemic of a severe hemorrhagic fever disease in Africa. Although two monoclonal antibody (mAb) drugs have recently received approval in the USA, additional therapeutics are still needed to combat potential outbreaks of resistance variants and other closely related ...
Ruikun, Du +3 more
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2006
As a major pathogen of human and certain animal species, influenza virus causes wide spread and potentially devastating disease. To initiate infection, the virus first binds to cellular receptors comprising either -(2,3 ) or -(2,6) linked sialic acid. Recent advances in our understanding of the influenza virus receptor and viral host species involved ...
Xiangjie, Sun, Gary R, Whittaker
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As a major pathogen of human and certain animal species, influenza virus causes wide spread and potentially devastating disease. To initiate infection, the virus first binds to cellular receptors comprising either -(2,3 ) or -(2,6) linked sialic acid. Recent advances in our understanding of the influenza virus receptor and viral host species involved ...
Xiangjie, Sun, Gary R, Whittaker
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Unlocking entry for yellow fever virus
Nature Reviews MicrobiologyShimona Starling, Starling Shimona
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Entry Inhibitors of Hepatitis C Virus
2022Hepatitis C virus (HCV) infection affects approximately 1% of the world's population and is a major cause of chronic liver diseases. Although antiviral therapy consisting of direct-acting antivirals (DAAs) can cure the majority of HCV patients, it is still limited by viral resistances, drug-drug interactions, and high costs.
Xi-Jing, Qian, Zhong-Tian, Qi
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Mechanisms of cell entry by influenza virus
Expert Reviews in Molecular Medicine, 2001A wide range of viruses, including many human and animal pathogens representing various taxonomic groups, contain genomes that are enclosed in lipid envelopes. These envelopes are generally acquired in the final stages of assembly, as viruses bud from regions of the membrane of the infected cell at which virally encoded membrane proteins have ...
K J, Cross +2 more
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Nonpeptide Inhibitors of Measles Virus Entry
Journal of Medicinal Chemistry, 2006Measles virus (MV) is one of the most infectious pathogens known. Despite the existence of a vaccine, over 500,000 deaths/year result from MV or associated complications. Anti-measles compounds could conceivably reverse these statistics. Previously, we described a homology model of the MV fusion protein trimer and a putative binding site near the head ...
Aiming, Sun +12 more
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