Results 21 to 30 of about 79,379 (205)

Current In Vitro Models to Study Varicella Zoster Virus Latency and Reactivation [PDF]

Viruses, 2019
Abel Viejo-Borbolla, Catherine M Pearce, Nicholas L Baird   +2 more
exaly   +2 more sources

Live Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Undergoes an Abortive Replication Cycle in the TG Neurons following Latency Reactivation

Viruses, 2023
Like other alpha herpesviruses, pseudorabies virus (PRV) establishes lifelong latency in trigeminal ganglionic (TG) neurons. Upon stress, the latent viruses in the TG neurons reactivate and are transported anterograde from the neuron cell bodies to the ...
Selvaraj Pavulraj, Rhett W. Stout, Daniel B. Paulsen, Shafiqul I. Chowdhury   +3 more
doaj   +1 more source

The efficacy and tolerability of latency-reversing agents in reactivating the HIV-1 reservoir in clinical studies: a systematic review

Journal of Virus Eradication, 2023
Introduction: Understanding the clinical potency of latency-reversing agents (LRAs) on the HIV-1 reservoir is useful to deploy future strategies. This systematic review evaluated the effects of LRAs in human intervention studies.
Quinten Debrabander, Kathryn S. Hensley, Christina K. Psomas, Wichor Bramer, Tokameh Mahmoudi, Berend J. van Welzen, Annelies Verbon, Casper Rokx   +7 more
doaj   +1 more source

HIV, HSV, SARS-CoV-2 and Ebola Share Long-Term Neuropsychiatric Sequelae

Neuropsychiatric Disease and Treatment, 2022
Pascal Büttiker,1 George B Stefano,1 Simon Weissenberger,2 Radek Ptacek,1 Martin Anders,1 Jiri Raboch,1 Richard M Kream1 1Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech ...
Büttiker P, Stefano GB, Weissenberger S, Ptacek R, Anders M, Raboch J, Kream RM   +6 more
doaj  

Initiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activation

Journal of the International AIDS Society, 2016
Introduction Colonic infiltration by HIV occurs soon after infection, establishing a persistent viral reservoir and a barrier to cure. We investigated virologic and immunologic correlates of detectable colonic HIV RNA during acute HIV infection (AHI) and
Trevor A Crowell, James LK Fletcher, Irini Sereti, Suteeraporn Pinyakorn, Robin Dewar, Shelly J Krebs, Nitiya Chomchey, Rungsun Rerknimitr, Alexandra Schuetz, Nelson L Michael, Nittaya Phanuphak, Nicolas Chomont, Jintanat Ananworanich, for the RV254/SEARCH010 Study Group   +13 more
doaj   +1 more source

Herpes simplex virus 1 regulates β-catenin expression in TG neurons during the latency-reactivation cycle.

PLoS ONE, 2020
When herpes simplex virus 1 (HSV-1) infection is initiated in the ocular, nasal, or oral cavity, sensory neurons within trigeminal ganglia (TG) become infected.
Kelly S Harrison, Liqian Zhu, Prasanth Thunuguntla, Clinton Jones   +3 more
doaj   +1 more source

Understanding Factors That Modulate the Establishment of HIV Latency in Resting CD4+ T-Cells In Vitro. [PDF]

PLoS ONE, 2016
Developing robust in vitro models of HIV latency is needed to better understand how latency is established, maintained and reversed. In this study, we examined the effects of donor variability, HIV titre and co-receptor usage on establishing HIV latency ...
Jenny L Anderson, Talia M Mota, Vanessa A Evans, Nitasha Kumar, Simin D Rezaei, Karey Cheong, Ajantha Solomon, Fiona Wightman, Paul U Cameron, Sharon R Lewin   +9 more
doaj   +1 more source

Waking Up the Sleepers: HIV Latency and Reactivation

Journal of the Formosan Medical Association, 2008
In a patient infected with HIV-1, the presence of latently infected cells from which the virus can be reactivated and rekindle HIV infection in the patient necessitates lifelong administration of antiretroviral treatment.
Hoi Ping Mok, Andrew Lever
doaj   +1 more source

HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells. [PDF]

PLoS Pathogens, 2015
Highly active antiretroviral therapy (HAART) suppresses human immunodeficiency virus (HIV) replication to undetectable levels but cannot fully eradicate the virus because a small reservoir of CD4+ T cells remains latently infected.
Leonard Chavez, Vincenzo Calvanese, Eric Verdin   +2 more
doaj   +1 more source

A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo. [PDF]

PLoS Pathogens, 2014
Gammaherpesviruses such as Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV, HHV-8) establish lifelong latency in their hosts and are associated with the development of several types of malignancies, including a subset of B cell
Carrie B Coleman, Jennifer E McGraw, Emily R Feldman, Alexa N Roth, Lisa R Keyes, Katrina R Grau, Stephanie L Cochran, Thomas J Waldschmidt, Chengyu Liang, J Craig Forrest, Scott A Tibbetts   +10 more
doaj   +1 more source