Results 21 to 30 of about 75,185 (247)

RNA editing of microRNA prevents RNA-induced silencing complex recognition of target mRNA [PDF]

Open Biology, 2015
MicroRNAs (miRNAs) integrate with Argonaut (Ago) to create the RNA-induced silencing complex, and regulate gene expression by silencing target mRNAs. RNA editing of miRNA may affect miRNA processing, assembly of the Ago complex and target mRNA binding ...
Yalei Cui, Tianzhi Huang, Xiaobo Zhang   +2 more
doaj   +1 more source

Current In Vitro Models to Study Varicella Zoster Virus Latency and Reactivation [PDF]

Viruses, 2019
Catherine M Pearce, Abel Viejo-Borbolla
exaly   +2 more sources

Feline immunodeficiency virus latency [PDF]

Retrovirology, 2013
Despite highly effective anti-retroviral therapy, HIV is thought to persist in patients within long-lived cellular reservoirs in the form of a transcriptionally inactive (latent) integrated provirus. Lentiviral latency has therefore come to the forefront of the discussion on the possibility of a cure for HIV infection in humans.
McDonnel, Samantha J, Sparger, Ellen E, Murphy, Brian G   +2 more
openaire   +4 more sources

Live Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Undergoes an Abortive Replication Cycle in the TG Neurons following Latency Reactivation

Viruses, 2023
Like other alpha herpesviruses, pseudorabies virus (PRV) establishes lifelong latency in trigeminal ganglionic (TG) neurons. Upon stress, the latent viruses in the TG neurons reactivate and are transported anterograde from the neuron cell bodies to the ...
Selvaraj Pavulraj, Rhett W. Stout, Daniel B. Paulsen, Shafiqul I. Chowdhury   +3 more
doaj   +1 more source

TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency [PDF]

Molecular Cell, 2019
Mariko Kobayashi, Moses V Chao, Angus C Wilson   +2 more
exaly   +2 more sources

The efficacy and tolerability of latency-reversing agents in reactivating the HIV-1 reservoir in clinical studies: a systematic review

Journal of Virus Eradication, 2023
Introduction: Understanding the clinical potency of latency-reversing agents (LRAs) on the HIV-1 reservoir is useful to deploy future strategies. This systematic review evaluated the effects of LRAs in human intervention studies.
Quinten Debrabander, Kathryn S. Hensley, Christina K. Psomas, Wichor Bramer, Tokameh Mahmoudi, Berend J. van Welzen, Annelies Verbon, Casper Rokx   +7 more
doaj   +1 more source

Initiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activation

Journal of the International AIDS Society, 2016
Introduction Colonic infiltration by HIV occurs soon after infection, establishing a persistent viral reservoir and a barrier to cure. We investigated virologic and immunologic correlates of detectable colonic HIV RNA during acute HIV infection (AHI) and
Trevor A Crowell, James LK Fletcher, Irini Sereti, Suteeraporn Pinyakorn, Robin Dewar, Shelly J Krebs, Nitiya Chomchey, Rungsun Rerknimitr, Alexandra Schuetz, Nelson L Michael, Nittaya Phanuphak, Nicolas Chomont, Jintanat Ananworanich, for the RV254/SEARCH010 Study Group   +13 more
doaj   +1 more source

Understanding Factors That Modulate the Establishment of HIV Latency in Resting CD4+ T-Cells In Vitro. [PDF]

PLoS ONE, 2016
Developing robust in vitro models of HIV latency is needed to better understand how latency is established, maintained and reversed. In this study, we examined the effects of donor variability, HIV titre and co-receptor usage on establishing HIV latency ...
Jenny L Anderson, Talia M Mota, Vanessa A Evans, Nitasha Kumar, Simin D Rezaei, Karey Cheong, Ajantha Solomon, Fiona Wightman, Paul U Cameron, Sharon R Lewin   +9 more
doaj   +1 more source

HIV, HSV, SARS-CoV-2 and Ebola Share Long-Term Neuropsychiatric Sequelae

Neuropsychiatric Disease and Treatment, 2022
Pascal Büttiker,1 George B Stefano,1 Simon Weissenberger,2 Radek Ptacek,1 Martin Anders,1 Jiri Raboch,1 Richard M Kream1 1Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech ...
Büttiker P, Stefano GB, Weissenberger S, Ptacek R, Anders M, Raboch J, Kream RM   +6 more
doaj  

Waking Up the Sleepers: HIV Latency and Reactivation

Journal of the Formosan Medical Association, 2008
In a patient infected with HIV-1, the presence of latently infected cells from which the virus can be reactivated and rekindle HIV infection in the patient necessitates lifelong administration of antiretroviral treatment.
Hoi Ping Mok, Andrew Lever
doaj   +1 more source