Results 31 to 40 of about 75,185 (247)
PLoS ONE, 2020 When herpes simplex virus 1 (HSV-1) infection is initiated in the ocular, nasal, or oral cavity, sensory neurons within trigeminal ganglia (TG) become infected.
Kelly S Harrison +3 more
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HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells. [PDF]
PLoS Pathogens, 2015 Highly active antiretroviral therapy (HAART) suppresses human immunodeficiency virus (HIV) replication to undetectable levels but cannot fully eradicate the virus because a small reservoir of CD4+ T cells remains latently infected.
Leonard Chavez +2 more
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A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo. [PDF]
PLoS Pathogens, 2014 Gammaherpesviruses such as Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV, HHV-8) establish lifelong latency in their hosts and are associated with the development of several types of malignancies, including a subset of B cell
Carrie B Coleman +10 more
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Epstein-barr virus immortalization and latency [PDF]
Frontiers in Bioscience, 1999 Epstein-Barr virus infects human B lymphocytes. The interaction between the virus and these cells has been the subject of investigation for over three decades. Recent in vitro and in vivo studies, reviewed here, are revealing the mechanisms by which EBV induces and controls proliferation through the expression of six viral nuclear proteins and two ...
openaire +2 more sources
The molecular basis of herpes simplex virus latency [PDF]
FEMS Microbiology Reviews, 2012 Herpes simplex virus type 1 is a neurotropic herpesvirus that establishes latency within sensory neurones. Following primary infection, the virus replicates productively within mucosal epithelial cells and enters sensory neurones via nerve termini. The virus is then transported to neuronal cell bodies where latency can be established. Periodically, the
Nicoll, Michael P +2 more
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Interferon alpha induces establishment of alphaherpesvirus latency in sensory neurons in vitro.
PLoS ONE, 2010 BackgroundSeveral alphaherpesviruses, including herpes simplex virus 1 (HSV-1) and pseudorabies virus (PRV), establish lifelong latency in neurons of the trigeminal ganglion (TG).
Nick De Regge +4 more
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Acta Pharmaceutica Sinica B, 2020 Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral ...
Chang Yan +7 more
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Design of a First-in-Class homoPROTAC to Induce ICP0 Degradation in Human Herpes Simplex Virus 1
Drugs and Drug CandidatesBackground/Objectives: Human Herpes Simplex Virus 1 (HSV-1) is a common pathogen that establishes lifelong latent infections. The emergence of drug resistance necessitates novel therapeutic strategies.
Leyla Salimova +8 more
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Microbial Cell, 2016 Herpes simplex virus 1 (HSV-1) is a human pathogen that establishes latency in the nucleus of infected neurons in the PNS and the CNS. At the transcriptional level latency is characterized by a quasi-complete silencing of the extrachromosomal viral ...
Patrick Lomonte
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The Bovine Herpesvirus 1 Latency-Reactivation Cycle, a Chronic Problem in the Cattle Industry
Viruses, 2023 Bovine alphaherpesvirus 1 (BoHV-1) is a persistent and recurring disease that affects cattle worldwide. It is a major contributor to bovine respiratory disease and reproductive failure in the US.
Jeffery B. Ostler, Clinton Jones
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