Results 31 to 40 of about 76,448 (148)

Ablation of STAT3 in the B Cell Compartment Restricts Gammaherpesvirus Latency In Vivo

mBio, 2016
A challenging property of gammaherpesviruses is their ability to establish lifelong persistence. The establishment of latency in B cells is thought to involve active virus engagement of host signaling pathways.
Sandeep Steven Reddy, Hui-Chen Chang Foreman, Thubten Ozula Sioux, Gee Ho Park, Valeria Poli, Nancy C. Reich, Laurie T. Krug   +6 more
doaj   +1 more source

Immunological Considerations for the Development of an Effective Herpes Vaccine

Microorganisms
Research is underway to develop a vaccine to prevent and cure infection from herpes simplex virus (HSV). It emphasizes the critical need for immunization to address public health issues and the shortcomings of existing treatment options.
Mahmoud Singer, Mohamed I. Husseiny
doaj   +1 more source

Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells

Communications Biology, 2023
Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood.
Mie Kobayashi-Ishihara, Katarína Frazão Smutná, Florencia E. Alonso, Jordi Argilaguet, Anna Esteve-Codina, Kerstin Geiger, Meritxell Genescà, Judith Grau-Expósito, Clara Duran-Castells, Selina Rogenmoser, René Böttcher, Jennifer Jungfleisch, Baldomero Oliva, Javier P. Martinez, Manqing Li, Michael David, Makoto Yamagishi, Marta Ruiz-Riol, Christian Brander, Yasuko Tsunetsugu-Yokota, Maria J. Buzon, Juana Díez, Andreas Meyerhans   +22 more
doaj   +1 more source

Experimental investigation of herpes simplex virus latency [PDF]

Clinical Microbiology Reviews, 1997
The clinical manifestations of herpes simplex virus infection generally involve a mild and localized primary infection followed by asymptomatic (latent) infection interrupted sporadically by periods of recrudescence (reactivation) where virus replication and associated cytopathologic findings are manifest at the site of initial infection.
E K, Wagner, D C, Bloom
openaire   +2 more sources

People Living With HIV Have More Intact HIV DNA in Circulating CD4+ T Cells if They Have History of Pulmonary Tuberculosis

Pathogens and Immunity
Background: A primary barrier to curing HIV is the HIV reservoir. The leading infectious cause of death worldwide for people living with HIV is tuberculosis (TB), but we do not know how TB impacts the HIV reservoir.
Marc Antoine Jean Juste, Yvetot Joseph, Dominique Lespinasse, Alexandra Apollon, Parmida Jamshidi, Myung Hee Lee, Maureen Ward, Esther Brill, Yanique Duffus, Uche Chukwukere, Ali Danesh, Winiffer Alberto, Daniel Fitzgerald, Jean Pape, R Jones, Kathryn Dupnik   +15 more
doaj   +1 more source

IFNβ absence compensates for LAT functions in latency reactivation and T cell exhaustion

Journal of Virology
Type I interferons (IFNs) generate strong antiviral immunity following viral infection in mice and humans. These type I IFNs are encoded by at least 14 IFNα genes and a single IFNβ gene.
Shaohui Wang, Ujjaldeep Jaggi, Jay J. Oh, Homayon Ghiasi   +3 more
doaj   +1 more source

Human Cytomegalovirus US28 Ligand Binding Activity Is Required for Latency in CD34⁺ Hematopoietic Progenitor Cells and Humanized NSG Mice

mBio, 2019
Human cytomegalovirus (HCMV) infection of CD34+ hematopoietic progenitor cells (CD34+ HPCs) provides a critical reservoir of virus in stem cell transplant patients, and viral reactivation remains a significant cause of morbidity and mortality.
Lindsey B. Crawford, Patrizia Caposio, Craig Kreklywich, Andrew H. Pham, Meaghan H. Hancock, Taylor A. Jones, Patricia P. Smith, Andrew D. Yurochko, Jay A. Nelson, Daniel N. Streblow   +9 more
doaj   +1 more source

Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells. [PDF]

PLoS ONE, 2011
Epstein-Barr virus (EBV) is implicated in the pathogenesis of multiple human tumours of lymphoid and epithelial origin. The virus infects and immortalizes B cells establishing a persistent latent infection characterized by varying patterns of EBV latent ...
Sandra N Schlick, C David Wood, Andrea Gunnell, Helen M Webb, Sarika Khasnis, Aloys Schepers, Michelle J West   +6 more
doaj   +1 more source

Binding of herpesvirus entry mediator (HVEM) and HSV-1 gD affect reactivation but not latency levels.

PLoS Pathogens, 2023
Previously we reported that the HSV-1 latency associated transcript (LAT) specifically upregulates the cellular herpesvirus entry mediator (HVEM) but no other known HSV-1 receptors.
Ujjaldeep Jaggi, Shaohui Wang, Kevin R Mott, Homayon Ghiasi   +3 more
doaj   +1 more source

Epstein-Barr Virus – pathogenesis, latency and cancers

Journal of Pre-Clinical and Clinical Research, 2017
summary in the ...
Ewa Kliszczewska, Adrian Jarzyński, Anastazja Boguszewska, Justyna Pasternak, Małgorzata Polz-Dacewicz   +4 more
openaire   +2 more sources