Results 31 to 40 of about 79,379 (205)

Interferon alpha induces establishment of alphaherpesvirus latency in sensory neurons in vitro.

PLoS ONE, 2010
BackgroundSeveral alphaherpesviruses, including herpes simplex virus 1 (HSV-1) and pseudorabies virus (PRV), establish lifelong latency in neurons of the trigeminal ganglion (TG).
Nick De Regge, Nina Van Opdenbosch, Hans J Nauwynck, Stacey Efstathiou, Herman W Favoreel   +4 more
doaj   +1 more source

Disturbed Yin–Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1

Acta Pharmaceutica Sinica B, 2020
Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral ...
Chang Yan, Zhuo Luo, Wen Li, Xue Li, Robert Dallmann, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He   +7 more
doaj   +1 more source

Design of a First-in-Class homoPROTAC to Induce ICP0 Degradation in Human Herpes Simplex Virus 1

Drugs and Drug Candidates
Background/Objectives: Human Herpes Simplex Virus 1 (HSV-1) is a common pathogen that establishes lifelong latent infections. The emergence of drug resistance necessitates novel therapeutic strategies.
Leyla Salimova, Ali Sahin, Ozge Ardicli, Fatima Hacer Kurtoglu Babayev, Zeynep Betul Sari, Muhammed Emin Sari, Muhammet Guzel Kurtoglu, Sena Ardicli, Huseyn Babayev   +8 more
doaj   +1 more source

The interaction between herpes simplex virus 1 genome and promyelocytic leukemia nuclear bodies (PML-NBs) as a hallmark of the entry in latency

Microbial Cell, 2016
Herpes simplex virus 1 (HSV-1) is a human pathogen that establishes latency in the nucleus of infected neurons in the PNS and the CNS. At the transcriptional level latency is characterized by a quasi-complete silencing of the extrachromosomal viral ...
Patrick Lomonte
doaj   +1 more source

The Bovine Herpesvirus 1 Latency-Reactivation Cycle, a Chronic Problem in the Cattle Industry

Viruses, 2023
Bovine alphaherpesvirus 1 (BoHV-1) is a persistent and recurring disease that affects cattle worldwide. It is a major contributor to bovine respiratory disease and reproductive failure in the US.
Jeffery B. Ostler, Clinton Jones
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Locus-specific proteomics identifies novel regulators of Epstein-Barr virus lytic reactivation

Journal of Virology
The Epstein-Barr virus (EBV) is a human gamma-herpesvirus which infects over 90% of the global population and is associated with lymphoid and epithelioid cancers. After infection, EBV enters a latent state in B cells, whereby the viral genome persists as
Daniel E. Greaves, Ildar Gabaev, James C. Williamson, Stuart Bloor, Sergio Martinez Cuesta, Nicholas J. Matheson, Lori Frappier, Jérôme Déjardin, Paul J. Lehner   +8 more
doaj   +1 more source

Ablation of STAT3 in the B Cell Compartment Restricts Gammaherpesvirus Latency In Vivo

mBio, 2016
A challenging property of gammaherpesviruses is their ability to establish lifelong persistence. The establishment of latency in B cells is thought to involve active virus engagement of host signaling pathways.
Sandeep Steven Reddy, Hui-Chen Chang Foreman, Thubten Ozula Sioux, Gee Ho Park, Valeria Poli, Nancy C. Reich, Laurie T. Krug   +6 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Immunological Considerations for the Development of an Effective Herpes Vaccine

Microorganisms
Research is underway to develop a vaccine to prevent and cure infection from herpes simplex virus (HSV). It emphasizes the critical need for immunization to address public health issues and the shortcomings of existing treatment options.
Mahmoud Singer, Mohamed I. Husseiny
doaj   +1 more source