Results 51 to 60 of about 76,448 (148)

The molecular mechanisms of Epstein-Barr virus persistence in the human organism

Annals of Mechnikov's Institute, 2020
This review describes advances in molecular aspects of EBV infection and disease. We discuss the spectrum of clinical illness due to EBV persistent infection.
A Volyanskiy, T Kolotova, E Romanova, T Sidorenko, N Igumnova, E Konoreva, V Yukhimenko, T Kabluchko, M Pogorila   +8 more
doaj  

IFI16 Partners with KAP1 to Maintain Epstein-Barr Virus Latency. [PDF]

J Virol, 2022
Xu H, Li X, Rousseau BA, Akinyemi IA, Frey TR, Zhou K, Droske LE, Mitchell JA, McIntosh MT, Bhaduri-McIntosh S.   +9 more
europepmc   +1 more source

Recent Advances in the Study of Alphaherpesvirus Latency and Reactivation: Novel Guidance for the Design of Herpesvirus Live Vector Vaccines

Pathogens
Alphaherpesviruses, including herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella-zoster virus (VZV), infect a diverse array of hosts, spanning both humans and animals.
Shinuo Cao, Mo Zhou, Shengwei Ji, Dongxue Ma, Shanyuan Zhu   +4 more
doaj   +1 more source

Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host

Frontiers in Microbiology, 2016
Herpesviruses establish a chronic infection in the host characterized by intervals of lytic replication, quiescent latency, and reactivation from latency.
Laurie T Krug, Brandon Cieniewicz, Alexis Santana, Nana Minkah   +3 more
doaj   +1 more source

Establishment of an In Vitro Model of Pseudorabies Virus Latency and Reactivation and Identification of Key Viral Latency-Associated Genes. [PDF]

Viruses, 2023
Pan L, Li M, Zhang X, Xia Y, Mian AM, Wu H, Sun Y, Qiu HJ.   +7 more
europepmc   +1 more source

Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice.

PLoS Pathogens
Human cytomegalovirus (HCMV) actively manipulates cellular signaling pathways to benefit viral replication. Phosphatidyl-inositol 3-kinase (PI3K)/Akt signaling is an important negative regulator of HCMV replication, and during lytic infection the virus ...
Nicole L Diggins, Andrew H Pham, Jennifer Mitchell, Christopher J Parkins, Luke Slind, Rebekah Turner, Byeong-Jae Lee, Andrew D Yurochko, Patrizia Caposio, Jay A Nelson, Meaghan H Hancock   +10 more
doaj   +1 more source

Epstein-Barr virus latency programs dynamically sensitize B cells to ferroptosis. [PDF]

Proc Natl Acad Sci U S A, 2022
Burton EM, Voyer J, Gewurz BE.
europepmc   +1 more source

Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

eLife
The persistence of latent viral reservoirs remains the major obstacle to eradicating human immunodeficiency virus (HIV). We herein found that ICP34.5 can act as an antagonistic factor for the reactivation of HIV latency by herpes simplex virus type I ...
Ziyu Wen, Pingchao Li, Yue Yuan, Congcong Wang, Minchao Li, Haohang Wang, Minjuan Shi, Yizi He, Mingting Cui, Ling Chen, Caijun Sun   +10 more
doaj   +1 more source

Molecular Basis of Epstein-Barr Virus Latency Establishment and Lytic Reactivation. [PDF]

Viruses, 2021
Murata T, Sugimoto A, Inagaki T, Yanagi Y, Watanabe T, Sato Y, Kimura H.   +6 more
europepmc   +1 more source

MLL1 is regulated by KSHV LANA and is important for virus latency. [PDF]

Nucleic Acids Res, 2021
Tan M, Li S, Juillard F, Chitas R, Custódio TF, Xue H, Szymula A, Sun Q, Liu B, Álvarez ÁL, Chen S, Huang J, Simas JP, McVey CE, Kaye KM.   +14 more
europepmc   +1 more source