Mathematical modelling of the interaction between cancer cells and an oncolytic virus: insights into the effects of treatment protocols [PDF]
Bulletin of Mathematical Biology 80: 1615-1629 (2018), 2019 Oncolytic virotherapy is an experimental cancer treatment that uses genetically engineered viruses to target and kill cancer cells. One major limitation of this treatment is that virus particles are rapidly cleared by the immune system, preventing them from arriving at the tumour site.
arxiv +1 more source
Prototype development of the Integral-Field unit for VIRUS [PDF]
, 2006 VIRUS is a planned integral-field instrument for the Hobby-Eberly Telescope (HET). In order to achieve a large field-of-view and high grasp at reasonable costs, the approach is to replicate integral-field units (IFU) and medium sized spectrographs many times.
arxiv +1 more source
A Branching Process for Virus Survival [PDF]
arXiv, 2011 Quasispecies theory predicts that there is a critical mutation probability above which a viral population will go extinct. Above this threshold the virus loses the ability to replicate the best adapted genotype, leading to a population composed of low replicating mutants that is eventually doomed.
arxiv
Evolutionary Dynamics of Giant Viruses and their Virophages [PDF]
arXiv, 2013 Giant viruses contain large genomes, encode many proteins atypical for viruses, replicate in large viral factories, and tend to infect protists. The giant virus replication factories can in turn be infected by so called virophages, which are smaller viruses that negatively impact giant virus replication.
arxiv
Punctuated evolution of influenza virus hemagglutinin (A/H1N1) under opposing migration and vaccination pressures [PDF]
arXiv, 2012 Influenza virus contains two highly variable envelope glycoproteins, hemagglutinin (HA) and neuraminidase (NA). The structure and properties of HA, which is responsible for binding the virus to the cell that is being infected, change significantly when the virus is transmitted from avian or swine species to humans. Previously we identified much smaller
arxiv
HIV-1 virus cycle replication: a review of RNA polymerase II transcription, alternative splicing and protein synthesis [PDF]
arXiv, 2019 HIV virus replication is a time-related process that includes several stages. Focusing on the core steps, RNA polymerase II transcripts in an early stage pre-mRNA containing regulator proteins (i.e nef,tat,rev,vif,vpr,vpu), which are completely spliced by the spliceosome complex (0.9kb and 1.8kb) and exported to the ribosome for protein synthesis ...
arxiv
The Program with a Personality: Analysis of Elk Cloner, the First Personal Computer Virus [PDF]
arXiv, 2020 Although self-replicating programs and viruses have existed since the 1960s and 70s, Elk Cloner was the first virus to circulate among personal computers in the wild. Despite its historical significance, it received comparatively little attention when it first appeared in 1982.
arxiv
Effective Motion of a Virus Trafficking Inside a Biological Cell [PDF]
arXiv, 2007 Virus trafficking is fundamental for infection success and plasmid cytosolic trafficking is a key step of gene delivery. Based on the main physical properties of the cellular transport machinery such as microtubules, motor proteins, our goal here is to derive a mathematical model to study cytoplasmic trafficking.
arxiv
Docking study for Protein Nsp-12 of SARS-CoV with Betalains and Alfa-Bisabolol [PDF]
arXiv, 2020 The present Health Crisis tests the response of modern science and medicine to finding treatment for a new COVID-19 disease. The presentation on the world stage of antivirals such as remdesivir, obeys to the continuous investigation of biologically active molecules with multiple theoretical, computational and experimental tools.
arxiv
Punctuated evolution of influenza virus neuraminidase (A/H1N1) under migration and vaccination pressures [PDF]
arXiv, 2012 Influenza virus contains two highly variable envelope glycoproteins, hemagglutinin (HA) and neuraminidase (NA). The structure and properties of HA, which is responsible for binding the virus to the cell that is being infected, change significantly when the virus is transmitted from avian or swine species to humans.
arxiv