Results 21 to 30 of about 434,946 (168)

Hepatitis D Virus Replication [PDF]

Cold Spring Harbor Perspectives in Medicine, 2015
This work reviews specific related aspects of hepatitis delta virus (HDV) reproduction, including virion structure, the RNA genome, the mode of genome replication, the delta antigens, and the assembly of HDV using the envelope proteins of its helper virus, hepatitis B virus (HBV).
openaire   +2 more sources

Intranuclear Positions of HIV-1 Proviruses Are Dynamic and Do Not Correlate with Transcriptional Activity

mBio, 2022
The relationship between spatiotemporal distribution of HIV-1 proviruses and their transcriptional activity is not well understood. To elucidate the intranuclear positions of transcriptionally active HIV-1 proviruses, we utilized an RNA fluorescence in ...
Ryan C. Burdick, Claire Deleage, Alice Duchon, Jacob D. Estes, Wei-Shau Hu, Vinay K. Pathak   +5 more
doaj   +1 more source

RNA Virus Replication Complexes

PLoS Pathogens, 2010
The majority of viruses infecting animals and plants today are RNA viruses [1]. There are double-stranded (ds) RNA viruses with dsRNA genomes, as well as (+) and (−)RNA viruses whose genomes are single-stranded (ss) RNA of either positive or negative polarity. RNA viruses have small genomes that rarely exceed 30 kb in size, and a large portion of their
Yizhi Jane Tao, Qiaozhen Ye
openaire   +4 more sources

Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing

mBio
Guanylate-binding protein (GBP) 5 is an interferon-inducible cellular factor with broad anti-viral activity. Recently, GBP5 has been shown to antagonize the glycoproteins of a number of enveloped viruses, in part by disrupting the host enzyme furin. Here
Hana Veler, Cheng Man Lun, Abdul A. Waheed, Eric O. Freed   +3 more
doaj   +1 more source

Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections

Viruses, 2020
Combination antiretroviral therapy (cART) controls but does not eradicate HIV infection; HIV persistence is the principal obstacle to curing infections.
Elizabeth M. Anderson, Francesco R. Simonetti, Robert J. Gorelick, Shawn Hill, Monica A. Gouzoulis, Jennifer Bell, Catherine Rehm, Liliana Pérez, Eli Boritz, Xiaolin Wu, Daria Wells, Stephen H. Hughes, Venigalla Rao, John M. Coffin, Mary F. Kearney, Frank Maldarelli   +15 more
doaj   +1 more source

Replication of Virus Plaques

Experimental Biology and Medicine, 1961
SummaryOne of the 2 suspended cell plaque technics described by Cooper(5) has been modified so that its sensitivity and precision for plaque assay of VEE and EEE virus are satisfactory for general purposes. In addition, the modified suspended cell technic permitted nearly quantitative replication of virus plaques. Feasibility of the method in simulated
A, BROWN, J E, OFFICER
openaire   +2 more sources

A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation

mBio
Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes an RNA-binding protein ORF57 in lytic infection. Using an optimized CLIP-seq in this report, we identified ORF57-bound transcripts from 544 host protein-coding genes.
Vladimir Majerciak, Beatriz Alvarado-Hernandez, Yanping Ma, Shivalee Duduskar, Alexei Lobanov, Maggie Cam, Zhi-Ming Zheng   +6 more
doaj   +1 more source

More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins

Retrovirology, 2017
The first responders of human antiviral immunity are components of the intrinsic immune response that reside within each and every one of our cells.
Guoli Shi, Olivier Schwartz, Alex A. Compton   +2 more
doaj   +1 more source

Discontinuous template switching generates coronavirus subgenomic RNAs from the 3ʹ viral genome end by 5ʹ to 3ʹ transcription

Journal of Virology
In coronavirus (CoV)-infected cells, several structural and accessory proteins are synthesized from subgenome RNAs (sgRNA) containing a common genomic 5ʹ-leader followed by a given open reading frame (ORF).
Ayslan Castro Brant, Zhe Hu, Angelika Zelma Chen, Vladimir Majerciak, Jonathan Yewdell, Zhi-Ming Zheng   +5 more
doaj   +1 more source

Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo

Retrovirology, 2019
Background Reverse transcription (RT) of HIV and SIV is initiated by the binding of the acceptor stem of tRNALys3 to the primer binding site (PBS) of the viral RNA genome.
Christine M. Fennessey, Celine Camus, Taina T. Immonen, Carolyn Reid, Frank Maldarelli, Jeffrey D. Lifson, Brandon F. Keele   +6 more
doaj   +1 more source