Results 41 to 50 of about 434,946 (168)

Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication

Cell Reports, 2019
Summary: HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP6) for viral production and primary cell replication.
Donna L. Mallery, K.M. Rifat Faysal, Alex Kleinpeter, Miranda S.C. Wilson, Marina Vaysburd, Adam J. Fletcher, Mariia Novikova, Till Böcking, Eric O. Freed, Adolfo Saiardi, Leo C. James   +10 more
doaj   +1 more source

Hepatitis C virus replication cycle

Journal of Hepatology, 2010
Ecole Normale Superieure de Lyon,Lyon F-69007, FranceHepatitis C virus (HCV) is a positive strand RNA virus forming thegenus Hepacivirus in the Flaviviridae family. Replication of HCVstarts with the virus binding to hepatocytes, which are the pri-mary, if not exclusive host cells. HCV entry is a multi-step andslow process (Panel 1).
Bartenschlager, Ralf, Cosset, Francois-Loic, Lohmann, Volker   +2 more
openaire   +2 more sources

Shedding light on virus replication [PDF]

Proceedings of the National Academy of Sciences, 2008
I am pleased to comment on “Visualizing the dynamics of viral replication in living cells via TAT peptide delivery of nuclease-resistant molecular beacons,” by Hsiao-Yun Yeh et al. (1), appearing in this issue of PNAS. I regard it as a very important contribution to animal (including human) virology because it allows observation of early events in ...
openaire   +2 more sources

HIV-1 transcription start sites usage and its impact on unspliced RNA functions in people living with HIV

mBio
HIV-1 unspliced RNA serves two distinct functions during viral replication: it is packaged into particles as the viral genome, and it is translated to generate Gag/Gag-Pol polyproteins required for virus assembly. Recent studies have demonstrated that in
Saiful Islam, Frank Maldarelli, Olga A. Nikolaitchik, Zetao Cheng, Robert Gorelick, Maria A. Nikolaitchik, Vinay K. Pathak, Wei-Shau Hu   +7 more
doaj   +1 more source

The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling

Cell Reports, 2017
Summary: Flaviviruses are enveloped, positive-sensed single-stranded RNA viruses that remodel host membranes, incorporating both viral and host factors facilitating viral replication.
Turgut E. Aktepe, Susann Liebscher, Julia E. Prier, Cameron P. Simmons, Jason M. Mackenzie   +4 more
doaj   +1 more source

Hepatitis C Virus RNA Replication [PDF]

, 2013
Genome replication is a crucial step in the life cycle of any virus. HCV is a positive strand RNA virus and requires a set of nonstructural proteins (NS3, 4A, 4B, 5A, and 5B) as well as cis-acting replication elements at the genome termini for amplification of the viral RNA.
openaire   +2 more sources

HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly

Nature Communications
The HIV-1 capsid is composed of capsid (CA) protein hexamers and pentamers (capsomers) that contain a central pore hypothesised to regulate capsid assembly and facilitate nucleotide import early during post-infection. These pore functions are mediated by
Alex Kleinpeter, Donna L. Mallery, Nadine Renner, Anna Albecka, J. Ole Klarhof, Eric O. Freed, Leo C. James   +6 more
doaj   +1 more source

Identification and Characterization of MmuPV1 Causing Papillomatosis Outbreak in an Animal Research Facility

Viruses
Mouse papillomavirus (MmuPV1) is the first papillomavirus known to infect laboratory mice, making it an irreplaceable tool for research on papillomaviruses. Despite wide use, standardized techniques for conducting MmuPV1 animal research are lacking.
Vladimir Majerciak, Kristin E. Killoran, Lulu Yu, Deanna Gotte, Elijah Edmondson, Matthew W. Breed, Renee E. King, Melody E. Roelke-Parker, Paul F. Lambert, Joshua A. Kramer, Zhi-Ming Zheng   +10 more
doaj   +1 more source

Tribute to Dr. Judith G. Levin (1934–2023)

Viruses
Dr. Judith G. Levin passed away in Teaneck, NJ, USA, on 8 December 2023 [...]
Karin Musier-Forsyth, Alan Rein, Eric O. Freed   +2 more
doaj   +1 more source

Replication of Molluscum Contagiosum Virus

Virology, 1995
Molluscum contagiosum virus (MCV) infects preadolescent children and sexually active adults, frequently causing a disfiguring cutaneous disease in immunosuppressed HIV-infected individuals. The development of an efficacious treatment regime has been hampered by the failure to replicate the virus in the laboratory. Here we report the first demonstration
BULLER, R.MARK L., BURNETT, J., CHEN, W., KREIDER, J.   +3 more
openaire   +2 more sources