Results 41 to 50 of about 205,339 (347)
Mutations in the Schmallenberg virus Gc glycoprotein facilitate cellular protein synthesis shutoff and restore pathogenicity of NSs deletion mutants in mice [PDF]
, 2016 Serial passage of viruses in cell culture has been traditionally used to attenuate virulence and identify determinants of viral pathogenesis. In a previous study, we found that a strain of Schmallenberg virus (SBV) serially passaged in tissue culture ...
Aislynn Taggart +13 more
core +1 more source
Adaption of seasonal H1N1 influenza virus in mice. [PDF]
PLoS ONE, 2011 The experimental infection of a mouse lung with influenza A virus has proven to be an invaluable model for studying the mechanisms of viral adaptation and virulence.
Lili Xu +12 more
doaj +1 more source
Roadblocks to translational challenges on viral pathogenesis. [PDF]
, 2013 Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive ...
Deeks, Steven +4 more
core +1 more source
Identification of an essential virulence gene of cyprinid herpesvirus 3 [PDF]
, 2017 The genus Cyprinivirus consists of a growing list of phylogenetically related viruses, some of which cause severe economic losses to the aquaculture industry. The archetypal member, cyprinid herpesvirus 3 (CyHV-3) causes mass mortalities worldwide in koi
Boutier, Maxime +5 more
core +2 more sources
Virus shedding kinetics and unconventional virulence tradeoffs
PLOS Pathogens, 2021 Tradeoff theory, which postulates that virulence provides both transmission costs and benefits for pathogens, has become widely adopted by the scientific community. Although theoretical literature exploring virulence-tradeoffs is vast, empirical studies validating various assumptions still remain sparse.
Andrew R. Wargo +3 more
openaire +4 more sources
Estudio genómico de cepas argentinas de Herpesvirus equino 1 [PDF]
, 2011 La infección por Herpesvirus equino 1 (EHV-1) tiene un significativo impacto económico en la producción equina mundial al causar abortos, enfermedad respiratoria, muertes perinatales y desórdenes neurológicos.
Eöry, Matías Leonel +5 more
core +2 more sources
The relationship of within-host multiplication and virulence in a plant-virus system. [PDF]
PLoS ONE, 2007 Virulence does not represent any obvious advantage to parasites. Most models of virulence evolution assume that virulence is an unavoidable consequence of within-host multiplication of parasites, resulting in trade-offs between within-host multiplication
Israel Pagán +2 more
doaj +1 more source
Molecular basis for a lack of correlation between viral fitness and cell killing capacity. [PDF]
PLoS Pathogens, 2007 The relationship between parasite fitness and virulence has been the object of experimental and theoretical studies often with conflicting conclusions. Here, we provide direct experimental evidence that viral fitness and virulence, both measured in the ...
Mónica Herrera +4 more
doaj +1 more source
Determinants of virulence of influenza A virus [PDF]
European Journal of Clinical Microbiology & Infectious Diseases, 2013 Influenza A viruses cause yearly seasonal epidemics and occasional global pandemics in humans. In the last century, four human influenza A virus pandemics have occurred. Occasionally, influenza A viruses that circulate in other species cross the species barrier and infect humans. Virus reassortment (i.e. mixing of gene segments of multiple viruses) and
Schrauwen, Eefje +5 more
openaire +2 more sources
Re-Assembly and Analysis of an Ancient Variola Virus Genome
Viruses, 2017 We report a major improvement to the assembly of published short read sequencing data from an ancient variola virus (VARV) genome by the removal of contig-capping sequencing tags and manual searches for gap-spanning reads. The new assembly, together with
Chad Smithson, Jacob Imbery, Chris Upton
doaj +1 more source