Results 61 to 70 of about 205,339 (347)

Truncation of the NS1 protein converts a low pathogenic avian influenza virus into a strong interferon inducer in duck cells [PDF]

, 2010
The NS1 protein of influenza A viruses is known as a nonessential virulence factor inhibiting type I interferon (IFN) production in mammals and in chicken cells. Whether NS1 inhibits the induction of type I IFNs in duck cells is currently unknown.
Guérin, Jean-Luc, Soubiès, Sébastien, Volmer, Christelle, Volmer, Romain   +3 more
core   +1 more source

Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in mice

Veterinary Research, 2017
Highly pathogenic avian influenza (HPAI) H5N8 virus has caused considerable economic losses to poultry industry and poses a great threat to public health.
Xiao Wang, Sujuan Chen, Dandan Wang, Xixin Zha, Siwen Zheng, Tao Qin, Wenjun Ma, Daxin Peng, Xiufan Liu   +8 more
doaj   +1 more source

Attenuated Porcine Reproductive and Respiratory Syndrome Virus Regains Its Fatal Virulence by Serial Passaging in Pigs or Porcine Alveolar Macrophages To Increase Its Adaptation to Target Cells

Microbiology Spectrum, 2022
Porcine reproductive and respiratory syndrome (PRRS) is a globally important disease threatening the pork industry, and modified live-virus (MLV) vaccines are widely used for its prevention.
Jingjing Wang, Mengsi Zhang, Xiaochun Cui, Xiang Gao, Weifeng Sun, Xinna Ge, Yongning Zhang, Xin Guo, Jun Han, Lei Zhou, Hanchun Yang   +10 more
doaj   +1 more source

Effects of Elevated CO2 and Temperature on Pathogenicity Determinants and Virulence of Potato virus X/Potyvirus-Associated Synergism

Molecular Plant-Microbe Interactions, 2015
Infections of plants by multiple viruses are common in nature and may result in synergisms in pathologies. Several environmental factors influence plant-virus interactions and act on virulence and host defense responses.
Emmanuel Aguilar, Lucía Allende, Francisco J. del Toro, Bong-Nam Chung, Tomás Canto, Francisco Tenllado   +5 more
doaj   +1 more source

Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context. [PDF]

, 2008
Engineered RNAs carrying substitutions in the integrin receptor-binding Arg-Gly-Asp (RGD) region of foot-and-mouth disease virus (FMDV) were constructed (aa 141-147 of VP1 capsid protein) and their infectivity was assayed in cultured cells and suckling
Baranowski, Eric, Gutiérrez-Rivas, Monica, Pulido, Miguel R, Sobrino, Francisco, Sáiz, Margarita   +4 more
core   +3 more sources

Transmission routes of African swine fever virus to domestic pigs: current knowledge and future research directions [PDF]

, 2016
African swine fever (ASF) is a major threat to the pig industry in Europe. Since 2007, ASF outbreaks have been ongoing in the Caucasus, Eastern Europe and the Baltic countries, causing severe economic losses for many pig farmers and pork producers.
BALDACCHINO, BLOME, BOINAS, COSTARD, DAVIES, DE CARVALHO FERREIRA, DE CARVALHO FERREIRA, DE CARVALHO FERREIRA, DE CARVALHO FERREIRA, DIAZ, EC, EC, EC, EC, EC, EFSA, EU, FAO, FAO, GABRIEL, GALLARDO, GALLARDO, GALLARDO, GOGIN, GREIG, GREIG, GUINAT, GUINAT, GULENKIN, HAAS, HEUSCHELE, HOWEY, IGLESIAS, KAGIRA, LANGE, MANZANO-ROMÁN, MCKERCHER, MCVICAR, MEBUS, MEBUS, MELLOR, MONTGOMERY, OGANESYAN, OIE, PARKER, PHENGSAVANH, PIETSCHMANN, PLOWRIGHT, PLOWRIGHT, PLOWRIGHT, ROWLANDS, SANCHEZ BOTIJA, SANCHEZ BOTIJA, SODEIKAT, THOMSON, THURFJELL, TURNER, VERGNE, VERGNE, VLASOVA, WILKINSON   +60 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Different Origins of Newcastle Disease Virus Hemagglutinin-Neuraminidase Protein Modulate the Replication Efficiency and Pathogenicity of the Virus

Frontiers in Microbiology, 2017
To investigate the exact effects of different origins of Newcastle disease virus (NDV) hemagglutinin-neuraminidase (HN) protein to the biological characteristics of the virus, we systematically studied the correlation between the HN protein and NDV ...
Ji-hui Jin, Jin-long Cheng, Zi-rong He, Ying-chao Ren, Xiao-hui Yu, Yang Song, Hui-ming Yang, Yan-ling Yang, Tong Liu, Guo-zhong Zhang, Guo-zhong Zhang   +10 more
doaj   +1 more source

Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity [PDF]

, 2017
Indexación: Web of Science; Scopus.The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide.
Alexis M. Kalergis, Alexis M. Kalergis, Claudia A. Riedel, Emma Rey-Jurado, Gisela Canedo-Marroquín, Juan M. Saavedra, Margarita K. Lay, Margarita K. Lay, Orlando Acevedo-Acevedo, Susan M. Bueno   +9 more
core   +2 more sources

Virulence and pathogenesis of non-virulent and virulent strains of pseudorabies virus expressing envelope glycoprotein E1 of hog cholera virus

Journal of General Virology, 1994
Pseudorabies virus (PRV) expressing the envelope glycoprotein E1 (E1) of hog cholera virus (HCV) was used as a model to study the potential risks connected with the use of a live herpesvirus vaccine expressing a foreign gene. The gene encoding E1 was inserted into the glycoprotein X (gX) locus of both a virulent PRV strain and a non-virulent PRV strain
W A, Mulder, J, Priem, K L, Glazenburg, F, Wagenaar, E, Gruys, A L, Gielkens, J M, Pol, T G, Kimman   +7 more
openaire   +2 more sources