Results 81 to 90 of about 111,893 (295)

In Ovo Models to Predict Virulence of Highly Pathogenic Avian Influenza H5-Viruses for Chickens and Ducks

Viruses
Highly pathogenic avian influenza (HPAI) H5-viruses are circulating in wild birds and are repeatedly introduced to poultry causing outbreaks in the Netherlands since 2014.
Luca Bordes, José L. Gonzales, Sandra Vreman, Sandra Venema, Nadia Portier, Evelien A. Germeraad, Wim H. M. van der Poel, Nancy Beerens   +7 more
doaj   +1 more source

The causes and consequences of changes in virulence following pathogen host shifts.

PLoS Pathogens, 2015
Emerging infectious diseases are often the result of a host shift, where the pathogen originates from a different host species. Virulence--the harm a pathogen does to its host-can be extremely high following a host shift (for example Ebola, HIV, and SARs)
Ben Longdon, Jarrod D Hadfield, Jonathan P Day, Sophia C L Smith, John E McGonigle, Rodrigo Cogni, Chuan Cao, Francis M Jiggins   +7 more
doaj   +1 more source

Genomic polymorphism of the pandemic A (H1N1) influenza viruses correlates with viral replication, virulence, and pathogenicity in vitro and in vivo. [PDF]

PLoS ONE, 2011
The novel pandemic A (H1N1) virus was first identified in Mexico in April 2009 and quickly spread worldwide. Like all influenzas, the H1N1 strain-specific properties of replication, virulence, and pathogenicity are a result of the particular genomic ...
Lili Xu, Linlin Bao, Jianfang Zhou, Dayan Wang, Wei Deng, Qi Lv, Yila Ma, Fengdi Li, Huihui Sun, Lingjun Zhan, Hua Zhu, Chunmei Ma, Yuelong Shu, Chuan Qin   +13 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

Replication efficiency of oncolytic vaccinia virus in cell cultures prognosticates the virulence and antitumor efficacy in mice

Journal of Translational Medicine, 2011
Background We have shown that insertion of the three vaccinia virus (VACV) promoter-driven foreign gene expression cassettes encoding Renilla luciferase-Aequorea GFP fusion protein, β-galactosidase, and β-glucuronidase into the F14.5L, J2R, and A56R loci
Yu Yong A, Chen Nanhai G, Zhang Qian, Szalay Aladar A   +3 more
doaj   +1 more source

A Comparison of the Vertical Transmission of High- and Low-Virulence Nucleopolyhedrovirus Strains in Lymantria Dispar L.

Insects, 2020
Baculoviruses can persist in insect host organisms after infection and may be vertically transmitted to the next generation, in which they may be reactivated.
Yuriy B. Akhanaev, Irina A. Belousova, Darya A. Lebedeva, Sergey V. Pavlushin, Vyacheslav V. Martemyanov   +4 more
doaj   +1 more source

NS_A530C mutation inhibited virus virulence.

, 2023
(A) MLD50 of WT and mutant viruses. MLD50 was calculated by the Reed and Muench method. (B and C) Weight loss and mortality of mice infected with each indicted virus.
Jiahui Zou (14406345), Hongbo Zhou (117916), Huanchun Chen (38125), Yuanbao Zhou (15286100), Shan Tian (4491718), Meilin Jin (117924), Ruifang Wang (728866), Luyao Yu (6170966), Yinxing Zhu (6320228), Ying Ran (9463664)   +9 more
core   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Pathogénicité du virus atténué de la peste des petits ruminants chez des moutons et des chèvres

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1990
Avec les passages du virus PPR sur les cellules Vero, on a noté une diminution progressive de sa virulence vis-à-vis des chevreaux. Les chèvres inoculées avec le virus au 60e passage ont présenté la maladie clinique avec des cas de mortalité alors que ...
F.D. Adu, T. Joannis, E. Nwosuh, A. Abegunde   +3 more
doaj   +1 more source