Results 91 to 100 of about 1,547,632 (301)

Synthetic Particulate Subunit Vaccines Co‐Delivering Multiple Antigens Induce Protective Immunity Against Melioidosis

Advanced NanoBiomed Research, EarlyView.
Engineered endotoxin‐free Escherichia coli were used to assemble poly(3‐hydroxybutyrate) (PHB) biopolymer particles displaying multiple conserved Burkholderia pseudomallei antigens via PhaC‐mediated surface presentation. Following formulation with poly(I:C), the particulate vaccines induced antigen‐specific humoral and cellular immune responses ...
Md. Tanvir Kabir, Shuxiong Chen, Justine B. Bendo, Ashley Johnson, Aleksandra W. Debowski, Mitali Sarkar‐Tyson, Bernd H. A. Rehm   +6 more
wiley   +1 more source

MiRNA Targeted NP Genome of Live Attenuated Influenza Vaccines Provide Cross-Protection against a Lethal Influenza Virus Infection

Vaccines, 2020
The miRNA-based strategy has been used to develop live attenuated influenza vaccines. In this study, the nucleoprotein (NP) genome segment of the influenza virus was inserted by different perfect miRNA-192-5p target sites, and the virus was rescued by ...
Feixia Gao, Tianhan Yang, Xueying Liu, Feifei Xiong, Jian Luo, Yinglei Yi, Jiangfeng Fan, Ze Chen, Wen-Song Tan   +8 more
doaj   +1 more source

Molecular determinants of Ebola virus virulence in mice. [PDF]

PLoS Pathogens, 2006
Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme virulence of ZEBOV remains elusive.
Hideki Ebihara, Ayato Takada, Darwyn Kobasa, Steven Jones, Gabriele Neumann, Steven Theriault, Mike Bray, Heinz Feldmann, Yoshihiro Kawaoka   +8 more
doaj   +1 more source

Changes in the virulence of myxoma virus strains in Britain [PDF]

Epidemiology and Infection, 1987
SUMMARYNational surveys of the virulence of field strains of myxoma virus were carried out in 1975 (128 virus strains) and in 1981 (123 strains), using the virulence testing method employed in a similar survey in 1962. Results showed that the virulence of field strains had increased between 1962 and 1975, and again between 1975 and 1981.
J, Ross, M F, Sanders
openaire   +2 more sources

N-glycosylation of viral glycoprotein is a novel determinant for the tropism and virulence of highly pathogenic tick-borne bunyaviruses.

PLoS Pathogens
Severe fever with thrombocytopenia syndrome (SFTS) virus, a tick-borne bunyavirus, causes a severe/fatal disease termed SFTS; however, the viral virulence is not fully understood. The viral non-structural protein, NSs, is the sole known virulence factor.
Masayuki Shimojima, Satoko Sugimoto, Satoshi Taniguchi, Takahiro Maeki, Tomoki Yoshikawa, Takeshi Kurosu, Shigeru Tajima, Chang-Kweng Lim, Hideki Ebihara   +8 more
doaj   +1 more source

In Ovo Models to Predict Virulence of Highly Pathogenic Avian Influenza H5-Viruses for Chickens and Ducks

Viruses
Highly pathogenic avian influenza (HPAI) H5-viruses are circulating in wild birds and are repeatedly introduced to poultry causing outbreaks in the Netherlands since 2014.
Luca Bordes, José L. Gonzales, Sandra Vreman, Sandra Venema, Nadia Portier, Evelien A. Germeraad, Wim H. M. van der Poel, Nancy Beerens   +7 more
doaj   +1 more source

The causes and consequences of changes in virulence following pathogen host shifts.

PLoS Pathogens, 2015
Emerging infectious diseases are often the result of a host shift, where the pathogen originates from a different host species. Virulence--the harm a pathogen does to its host-can be extremely high following a host shift (for example Ebola, HIV, and SARs)
Ben Longdon, Jarrod D Hadfield, Jonathan P Day, Sophia C L Smith, John E McGonigle, Rodrigo Cogni, Chuan Cao, Francis M Jiggins   +7 more
doaj   +1 more source

Investigation of denugue virus envelope gene quasispecies variation in patient samples : implications for virus virulence and disease pathognesis [PDF]

, 2011
Due to the error-prone nature of RNA virus replication, each dengue virus (DV) exists as a quasispecies within the host. To investigate the hypothesis that DV quasispecies populations affect disease severity, serum samples were obtained from dengue ...
Love, Hannah
core   +4 more sources

Pathogénicité du virus atténué de la peste des petits ruminants chez des moutons et des chèvres

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1990
Avec les passages du virus PPR sur les cellules Vero, on a noté une diminution progressive de sa virulence vis-à-vis des chevreaux. Les chèvres inoculées avec le virus au 60e passage ont présenté la maladie clinique avec des cas de mortalité alors que ...
F.D. Adu, T. Joannis, E. Nwosuh, A. Abegunde   +3 more
doaj   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

Animal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary, Nidhishree N. S, Rakesh Kumar Pundir, Muhasin Asaf V. N, Anamika Mishra, Ashwin Ashok Raut, Megha Agarwal, Amod Kumar   +7 more
wiley   +1 more source