Results 111 to 120 of about 309,484 (272)
Neurobiology of Stress, 2015 Glutamate, the main excitatory neurotransmitter in the central nervous system, exerts its effect through ionotropic and metabotropic receptors.
Rachel D. Moloney +5 more
doaj +1 more source
Cytokines in the colon, central nervous system and serum of irritable bowel syndrome rats
European Journal of Medical Research, 2021 Objective The aim of this study was to detect the expression of interleukin (IL)-1β and transforming growth factor (TGF)-β1 in the colonic tissue and serum of irritable bowel syndrome (IBS) rats, as well as the distribution and expression of ...
Guanqun Chao +3 more
doaj +1 more source
Peripheral Mediators of Colorectal Nociception and Sensitization [PDF]
, 2012 Several ion channels are thought to facilitate colorectal afferent neuron sensitization, which contributes to abdominal pain in irritable bowel syndrome (IBS).
Kiyatkin, Michael E
core
Insights on adaptive and innate immunity in canine leishmaniosis [PDF]
, 2016 Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities.
Abi Abdallah +19 more
core +4 more sources
Evidence-Based Complementary and Alternative Medicine, 2020 Objective To explore whether the effect of electroacupuncture (EA) on visceral hypersensitivity (VH) in rats with irritable bowel syndrome (IBS) is related to the changes of astrocyte activation in the medial thalamus (MT) and anterior cingulate cortex ...
Min Zhao +9 more
semanticscholar +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Visceral hypersensitivity in endometriosis: a new target for treatment? [PDF]
Gut, 2011 In women presenting to gynaecological clinics with lower abdominal pain, the cause is frequently attributed to endometriosis irrespective of whether it is found to be minimal or extensive at laparoscopy. Irritable bowel syndrome (IBS) is also common in this setting, and it was speculated that the visceral hypersensitivity associated with this condition
Issa, B. +6 more
openaire +3 more sources
JCI Insight, 2019 Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal or avoidance of tissue damage. While pain arises from both the skin and viscera, we investigated whether pruritogenic irritant mechanisms also function within
J. Castro +16 more
semanticscholar +1 more source
Microbiota-neuroimmune cross-talk in stress-induced visceral hypersensitivity of the bowel.
American Journal of Physiology - Gastrointestinal and Liver Physiology, 2020 Visceral hypersensitivity of the lower gastrointestinal tract, defined as an increased response to colorectal distension, frequently prompts episodes of debilitating abdominal pain in Irritable Bowel Syndrome (IBS). Although the pathophysiology of IBS is
Isabelle A. M. van Thiel +3 more
semanticscholar +1 more source
Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations
Journal of Gastroenterology and Hepatology, EarlyView.ABSTRACT Background Functional dyspepsia (FD) is a common gastrointestinal disorder that significantly impacts patients' quality of life. Over a decade ago, the Asian Neurogastroenterology and Motility Association (ANMA) and the Asian Pacific Association of Gastroenterology (APAGE) jointly developed the first Asian consensus report on FD.
Sanjiv Mahadeva +28 more
wiley +1 more source