Results 41 to 50 of about 195,947 (275)

Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis

Nature, 2018
Visceral leishmaniasis causes considerable mortality and morbidity in many parts of the world. There is an urgent need for the development of new, effective treatments for this disease.
S. Wyllie, Michael G. Thomas, Stephen Patterson, Sabrinia D Crouch, M. De Rycker, R. Lowe, S. Gresham, Michael D. Urbaniak, T. Otto, L. Stojanovski, Frederick R. C. Simeons, Sujatha Manthri, Lorna M MacLean, F. Zuccotto, Nadine Homeyer, H. Pflaumer, Markus Boesche, Lalitha Sastry, P. Connolly, S. Albrecht, M. Berriman, G. Drewes, David W. Gray, S. Ghidelli-Disse, S. Dixon, J. Fiandor, P. Wyatt, M. Ferguson, A. Fairlamb, T. Miles, K. Read, I. Gilbert   +31 more
semanticscholar   +1 more source

Acute liver failure due to visceral leishmaniasis in Barcelona: a case report

BMC Infectious Diseases, 2019
Background Leishmaniasis is an emerging infectious disease. Due to human migration and tourism, visceral leishmaniasis may become more common in non-endemic areas. In the Mediterranean basin, visceral leishmaniasis typically occurs in rural regions. Case
Iratxe Martinez de Narvajas, Alba Díaz, Octavio Bassegoda, Adriá Carpio, Carla Fuster, María Eugenia Valls, Miriam J. Alvarez-Martínez, Carolina García-Vidal, Alejandro Soriano, José Antonio Martínez, Juan Ambrosioni   +10 more
doaj   +1 more source

Para-kala-azar dermal leishmaniasis in a patient in Brazil: a case report

Revista da Sociedade Brasileira de Medicina Tropical
Visceral leishmaniasis is common in Brazil and is caused by Leishmania (Leishmania) infantum/chagasi. Post-kala-azar dermal leishmaniasis frequently follows visceral leishmaniasis caused by L.
José Angelo Lauletta Lindoso, Carlos Henrique Valente Moreira, Beatriz Julieta Celeste, Luiza Keiko Matsuka Oyafuso, Pedro Moreira Folegatti, Eduard Evert Zijlstra   +5 more
doaj   +1 more source

Non-Leishmania Parasite in Fatal Visceral Leishmaniasis–Like Disease, Brazil

Emerging Infectious Diseases, 2019
Through whole-genome sequencing analysis, we identified non-Leishmania parasites isolated from a man with a fatal visceral leishmaniasis–like illness in Brazil. The parasites infected mice and reproduced the patient’s clinical manifestations.
S. Maruyama, A. K. M. de Santana, N. T. Takamiya, T. Y. Takahashi, L. A. Rogerio, C. B. Oliveira, Cristiane Milanezi, Viviane A Trombela, A. Cruz, A. R. Jesus, A. Barreto, A. M. Da Silva, R. Almeida, J. Ribeiro, J. Silva   +14 more
semanticscholar   +1 more source

TLR4 and TLR9 polymorphism: Probable role in susceptibility among the population of Bihar for Indian visceral leishmaniasis

Innate Immunity, 2021
Genetic variations in the host TLRs genes play an important role in susceptibility and/or resistance to visceral leishmaniasis by altering the host-pathogen interaction.
Abhishek Mandal, Manish Kumar, Ashish Kumar, Abhik Sen, Pradeep Das, Sushmita Das   +5 more
doaj   +1 more source

Leishmania infantum recombinant kinesin degenerated derived repeat (rKDDR): A novel potential antigen for serodiagnosis of visceral leishmaniasis

PLoS ONE, 2019
Visceral leishmaniasis (VL) or kala-azar, the most severe form of leishmaniasis, can lead to death if not properly diagnosed and treated. Correct identification of infected patients and reservoirs is vital for controlling the spread of leishmaniasis ...
L. Dhom-Lemos, A. Viana, J. L. R. Cunha, M. Cardoso, T. Mendes, G. R. Pinheiro, W. F. Siqueira, F. Lobo, Leandro de Freitas Teles, L. Bueno, S. Guimarães‐Carvalho, D. Bartholomeu, R. Fujiwara   +12 more
semanticscholar   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, EarlyView.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

Treatment of Visceral Leishmaniasis

Archives of Pediatrics & Adolescent Medicine, 1992
Sir .—Mahieu and Van Acker 1 reported a case of visceral leishmaniasis (kalaazar) in the November 1991 issue of AJDC . Several case reports were included in the references, but only a few were from Mediterranean countries in which the disease is more prevalent, as mentioned by the authors. I would like to bring our experience with this disease into the
openaire   +3 more sources

Bidirectional Interaction Between Liposomal Amphotericin B Pharmacokinetics and Parasite Dynamics in Patients With Post‐Kala‐Azar Dermal Leishmaniasis: Potential Implications for Optimal Dosing

Clinical Pharmacology &Therapeutics, EarlyView.
Post‐kala‐azar dermal leishmaniasis (PKDL) involves a high macrophage burden in which the Leishmania parasites reside. Liposomal amphotericin B (LAmB) plays a key role in the treatment of PKDL. The mononuclear phagocyte system (MPS) is crucial in the distribution of liposomal drugs as well as the leishmaniasis pathophysiology.
Wan‐Yu Chu, Om Prakash Singh, Shyam Sundar, Dinesh Mondal, Krishna Pandey, Pradeep Das, Ignace C. Roseboom, Sheeraz Raja, Ana Torres, Eugenia Carrillo, Alwin D.R. Huitema, Fabiana Alves, Thomas P.C. Dorlo   +12 more
wiley   +1 more source