Results 21 to 30 of about 186,710 (291)

Paclitaxel—A Valuable Tool for Inducing Visceral Pain in Preclinical Testing?

International Journal of Translational Medicine, 2023
Visceral pain is a unique clinical entity that lacks an effective and safe treatment. Proper preclinical models are essential for assessing new drugs developed for the treatment of this pathology.
Corina Andrei, Anca Zanfirescu, Dragoș Paul Mihai, Simona Negreș   +3 more
doaj   +1 more source

Estrous cycle influences excitatory amino acid transport and visceral pain sensitivity in the rat: Effects of early-life stress [PDF]

, 2016
Background: Early-life stress (ELS) is a recognized risk factor for chronic pain disorders, and females appear to be more sensitive to the negative effects of stress.
Cryan, John F., Dinan, Timothy G., Felice, Valeria D., Foley, Tara, Moloney, Rachel D., O'Mahony, Siobhain M., Sajjad, Jahangir   +6 more
core   +1 more source

Endocannabinoid-related compounds in gastrointestinal diseases [PDF]

, 2018
The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central levels.
Alessandra, D'Alessandro, Esposito, Giuseppe, Gigli, Stefano, Giovanni, Sarnelli, Marcella, Pesce, Osvaldo, Borrelli, Rosario, Cuomo, Seguella, Luisa   +7 more
core   +1 more source

Research hotspots and trends in visceral pain research: A global comprehensive bibliometric analysis

Frontiers in Molecular Neuroscience, 2023
BackgroundVisceral pain is a complex and heterogeneous disorder that is considered more prominent compared to somatic pain, due to its multiple and complex causes and accompanying emotional and mood disorders.
Le Guan, Le Guan, Yang Liu, Bin Wu, Aiqin Chen, Wucheng Tao, Chun Lin   +6 more
doaj   +1 more source

Stress-Induced Chronic Visceral Pain of Gastrointestinal Origin

Frontiers in Systems Neuroscience, 2017
Visceral pain is generally poorly localized and characterized by hypersensitivity to a stimulus such as organ distension. In concert with chronic visceral pain, there is a high comorbidity with stress-related psychiatric disorders including anxiety and ...
Beverley Greenwood-Van Meerveld, Beverley Greenwood-Van Meerveld, Beverley Greenwood-Van Meerveld, Anthony C. Johnson   +3 more
doaj   +1 more source

Stress-Induced Visceral Pain: Towards Animal Models of Irritable-Bowel Syndrome and Associated Co-morbidities

Frontiers in Psychiatry, 2015
Visceral pain is a global term used to describe pain originating from the internal organs, which is distinct from somatic pain. It is a hallmark of functional gastrointestinal disorders such as irritable bowel syndrome (IBS).
Rachel D Moloney, Siobhain Mary O' Mahony, Siobhain Mary O' Mahony, Timothy G Dinan, Timothy G Dinan, John F Cryan, John F Cryan   +6 more
doaj   +1 more source

Visceral Therapy and Physical Activity for Selected Dysfunctions, with Particular Emphasis on Locomotive Organ Pain in Pregnant Women—Importance of Reducing Oxidative Stress

Antioxidants, 2022
Movement is a physiological phenomenon and a fundamental aspect of the living human body in a global context (e.g., musculoskeletal system function) and local one (e.g., visceral system function). The local activity of the body is expressed in the rhythm
Małgorzata Wójcik, Grażyna Jarząbek-Bielecka, Piotr Merks, Dawid Luwański, Katarzyna Plagens-Rotman, Magdalena Pisarska-Krawczyk, Małgorzata Mizgier, Witold Kędzia   +7 more
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Zeta Inhibitory Peptide as a Novel Therapy to Control Chronic Visceral Hypersensitivity in a Rat Model. [PDF]

PLoS ONE, 2016
The pathogenesis of multiple chronic visceral pain syndromes, such as irritable bowel syndrome (IBS), is not well known, and as a result current therapies are ineffective. The objective of this study was to investigate the effect of spinal protein kinase
Ying Tang, Aiqin Chen, Yu Chen, Lixia Guo, Hengfen Dai, Yang Huang, Qianqian Chen, Chun Lin   +7 more
doaj   +1 more source

Effect of high level of bladder filling on spinal nociception and motoneuronal excitability [PDF]

, 2015
To verify whether high level of bladder distension may counteract the inhibitory effect of descending pathways on sacral spinal cord neurons and to investigate which spinal circuitries are possibly involved in such a viscero-somatic interaction ...
Carbone, Antonio, Conte, Carmela, Coppola, Gianluca, Cortese, Francesca, Fragiotta, Gaia, Mastroianni, Santo, Palleschi, Giovanni, Pastore, ANTONIO LUIGI, Perrotta, Armando, Pierelli, Francesco, Serrao, Mariano   +10 more
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Pathophysiology of visceral pain

Revista Dor, 2014
BACKGROUNDS AND OBJECTIVES: Visceral pain shows many pathophysiological properties that make this form of pain unique, not only because of the clinical properties of the sensation but also because the neurobiological mechanisms that mediate the sensory ...
Fernando Cervero
doaj   +1 more source