Results 91 to 100 of about 4,186,077 (394)

Heterogeneity of Axenfeld–Rieger Syndrome: Molecular and Clinical Findings in Chinese Patients

Frontiers in Genetics, 2021
Axenfeld–Rieger Syndrome (ARS) is a rare disease with a wide spectrum of ocular and systemic manifestations. The genetic spectrum of Chinese patients with ARS and genotype-phenotype correlations have yet to be described.
Youjia Zhang, Youjia Zhang, Xueli Chen, Li Wang, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Yuhong Chen, Yuhong Chen   +8 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Metabolic characterization of human aqueous humor in the cataract progression after pars plana vitrectomy

BMC Ophthalmology, 2018
Background While pars plana vitrectomy (PPV) has become the third most commonly performed surgery in the world, it can also induce multiple post complications easily.
Yinghong Ji, Xianfang Rong, Yi Lu
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Android Note Manager Application for People with Visual Impairment

, 2013
With the outburst of smart-phones today, the market is exploding with various mobile applications. This paper proposes an application using which visually impaired people can type a note in Grade 1 Braille and save it in the external memory of their ...
Venugopal, Gayatri
core   +1 more source

Development of a machine learning model to predict low vision aid fitting for visually impaired patients

Frontiers in Medicine
BackgroundAt present, the fitting of low-vision aids (LVA) for patients globally necessitates the intervention of highly skilled ophthalmologists and certified rehabilitation specialists.
Bingfa Dai, Bingfa Dai, Pengpeng Pei, Zunqi Kan, Hai Lan, Wenwen Ye, Wenwen Ye, Yang Yu, Yang Yu, Xuelan Chen, Xuelan Chen, Yuyuan Yan, Yuyuan Yan, Ting Chen, Ting Chen, Jianqing Zheng, Jianqing Zheng, Lijuan Huang, Lijuan Huang, Jianmin Hu, Jianmin Hu   +20 more
doaj   +1 more source

Prevalence, Causes and Social Factors of Visual Impairment among Chinese Adults: Based on a National Survey

International Journal of Environmental Research and Public Health, 2017
Visual impairment has become a global challenge, especially for developing countries. This study aims to estimate the prevalence, causes and social factors of visual impairment among Chinese adults.
Chao Guo, Zhenjie Wang, P. He, Gong Chen, Xiaoying Zheng   +4 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Submovements During Reaching Movements after Stroke [PDF]

, 2014
Neurological deficits after cerebrovascular accidents very frequently disrupt the kinematics of voluntary movements with the consequent impact in daily life activities.
Ghez, Claude, Laczko, Jozsef, Piovesan, Davide, Scheidt, Robert A., Simo, Lucia S.   +4 more
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source