Results 101 to 110 of about 810,739 (352)

Visual Network Analysis of Dynamic Metabolic Pathways [PDF]

, 2010
. We extend our previous work on the exploration of static metabolic networks to evolving, and therefore dynamic, pathways. We apply our visualization software to data from a simulation of early metabolism. Thereby, we show that our technique allows us
A. Ullrich, A. Ullrich, B.O. Palsson, C. Klukas, D. Weininger, E.R. Gansner, G. Battista Di, G. Caetano-Anollés, H. Wiener, J. Branke, J.C. Roberts, J.L. Faulon, K. Misue, K. Sugiyama, M. Albrecht, M. Rohrschneider, N.H. Horowitz, R. Rao, R. Steuer, R.A. Jensen, S. Diehl, U. Brandes, Y. Frishman   +22 more
core   +2 more sources

An enzyme‐linked immunosorbent assay (ELISA)‐based activity assay for AMP‐activated protein kinase (AMPK)

FEBS Open Bio, EarlyView.
Measuring AMP‐activated protein kinase (AMPK) activity in vitro is crucial for testing AMPK activators or inhibitors with therapeutic potential. Here, we report an enzyme‐linked immunosorbent assay (ELISA)‐based AMPK activity assay with simple steps and high sensitivity, which offers a simple, robust, and cost‐effective alternative to traditional ...
Trezze P. Nguyen, Shangze Lyu, Yang Liu
wiley   +1 more source

A multi-pathway hypothesis for human visual fear signaling

Frontiers in Systems Neuroscience, 2015
A hypothesis is proposed for five visual fear signaling pathways in humans, based on an analysis of anatomical connectivity from primate studies and human functional connectivity from brain imaging studies.
David N Silverstein, David N Silverstein, Martin eIngvar, Martin eIngvar   +3 more
doaj   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Loss and enhancement of layer-selective signals in geniculostriate and corticotectal pathways of adult human amblyopia

Cell Reports, 2021
Summary: How abnormal visual experiences early in life influence human subcortical pathways is poorly understood. Using high-resolution fMRI and pathway-selective visual stimuli, we investigate the influence of amblyopia on response properties and the ...
Wen Wen, Yue Wang, Jiawei Zhou, Sheng He, Xinghuai Sun, Hong Liu, Chen Zhao, Peng Zhang   +7 more
doaj  

Pathway Tools version 28.0: Integrated Software for Pathway/Genome Informatics and Systems Biology [PDF]

arXiv, 2015
Pathway Tools is a bioinformatics software environment with a broad set of capabilities. The software provides genome-informatics tools such as a genome browser, sequence alignments, a genome-variant analyzer, and comparative-genomics operations. It offers metabolic-informatics tools, such as metabolic reconstruction, quantitative metabolic modeling ...
arxiv  

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Being first matters: topographical representational similarity analysis of ERP signals reveals separate networks for audiovisual temporal binding depending on the leading sense [PDF]

, 2017
In multisensory integration, processing in one sensory modality is enhanced by complementary information from other modalities. Inter-sensory timing is crucial in this process as only inputs reaching the brain within a restricted temporal window are ...
Cecere, Roberto, Gross, Joachim, Thut, Gregor, Willis, Ashleigh   +3 more
core   +1 more source

Modes of Effective Connectivity within Cortical Pathways Are Distinguished for Different Categories of Visual Context: An fMRI Study

Frontiers in Behavioral Neuroscience, 2017
Context contributes to accurate and efficient information processing. To reveal the dynamics of the neural mechanisms that underlie the processing of visual contexts during the recognition of color, shape, and 3D structure of objects, we carried out ...
Qiong Wu, Jinglong Wu, Jinglong Wu, Shigeko Takahashi, Qiang Huang, Hongzan Sun, Qiyong Guo, Yoshio Ohtani, Yoshimichi Ejima, Xu Zhang, Chunlin Li, Tianyi Yan, Tianyi Yan   +12 more
doaj   +1 more source

Biologically inspired model simulating visual pathways and cerebellum function in human - Achieving visuomotor coordination and high precision movement with learning ability [PDF]

arXiv, 2016
In recent years, the interdisciplinary research between information science and neuroscience has been a hotspot. In this paper, based on recent biological findings, we proposed a new model to mimic visual information processing, motor planning and control in central and peripheral nervous systems of human.
arxiv