Results 81 to 90 of about 810,739 (352)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Pathways for Theoretical Advances in Visualization [PDF]

open access: yesIEEE Computer Graphics and Applications, 2017
There is little doubt that having a theoretic foundation will benefit the field of visualization, including its main subfields. Because there has been a substantial amount of work on taxonomies and conceptual models in the visualization literature and some recent work on theoretic frameworks, such a theoretic foundation is not a foolish or impractical ...
Jessie Kennedy   +4 more
openaire   +3 more sources

Projection-specific anatomy, physiology and behaviour in the mouse superior colliculus [PDF]

open access: yes, 2022
The superior colliculus (SC) projects to other brain centres through multiple pathways, which are thought to be important in rapid, visually guided behaviours. Projections to the visual thalamus and the periaqueductal gray have been hypothesised to be
Wheatcroft, Thomas George
core  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

DEPRIVATION AND STRABISMIC AMBLYOPIA: ABNORMALITIES IN GENICULOCORTICAL VISUAL PATHWAYS

open access: yesAlʹmanah Kliničeskoj Mediciny, 2016
Background: There are inconsistent data on the changes of functional performance in subcortical structures of visual system caused by early binocular vision impairment.
S. V. Alekseenko, P. Yu. Shkorbatova
doaj   +1 more source

Art meets science – empowering stroke patients to regain muscular control through creative graphics technology, psycho-physiology and neuroplasticity. [PDF]

open access: yes, 2012
Treating patients with a cerebrovascular accident or stroke is complicated by severity and site of brain lesion. Muscular control is lost when neural pathways are interrupted or damaged due to embolus, thrombosis or ruptured aneurysm.
Thompson, Simon
core  

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Neural Pathways Conveying Novisual Information to the Visual Cortex

open access: yesNeural Plasticity, 2013
The visual cortex has been traditionally considered as a stimulus-driven, unimodal system with a hierarchical organization. However, recent animal and human studies have shown that the visual cortex responds to non-visual stimuli, especially in ...
Wen Qin, Chunshui Yu
doaj   +1 more source

Neural Coding of Green Flash in Retinal Bipolar Pathways [PDF]

open access: yes, 2012
What visual information do the graded potentials among retinal bipolar pathways actually transmit from photoreceptors to ganglion cells? The answer does not exist. Even the graded electric signals have not been understood completely.
Caiping Hu
core   +1 more source

Visual responses in the lateral geniculate evoked by Cx36-independent rod pathways [PDF]

open access: yes, 2011
Emerging evidence indicates rods can communicate with retinal ganglion cells (RGCs) via pathways that do not involve gap-junctions. Here we investigated the significance of such pathways for central visual responses, using mice lacking a key gap junction
Allen, Annette E.   +5 more
core   +1 more source

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