Results 231 to 240 of about 112,142 (312)

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

Vitamin B12 Deficiency in the Diagnostic Work-Up of Global Developmental Delay: A Treatable and Time-Sensitive Condition. [PDF]

Nutrients
Pancheva R, Dzhogova M, Dimitrov L, Nikolova M, Mihaylova G, Panayotova V, Dobreva DA, Peycheva K, Galunska B, Merdzhanova A.   +9 more
europepmc   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

A Comparison of the Effects of Vitamin B12 and Folic Acid on Gait Recovery and Myelination After Femoral Nerve Injury in Rats. [PDF]

Int J Mol Sci
Basailović M, Jakovčevski I, Aksić M, Poleksić J, Basailović G, Divac N.   +5 more
europepmc   +1 more source

Methionine Synthase Interacts With the Methionine Adenosyl‐Transferase MATα2 and the DNA Methyltransferase DNMT3b in the Nucleus

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
This study shows that methionine synthase (MS) interacts with MATα2, responsible for SAM production, and the methyltransferase DNMT3b in the nucleus. These results support the idea that spatial compartmentalization of one‐carbon metabolism could play a major role in regulating the epigenome.
Manon Jeandel, Jean‐Marc Alberto, Okan Baspinar, Aurélie Robert, Natacha Dreumont, Zeinab Alsahly, David Meyre, Jean‐Louis Guéant, David Coelho   +8 more
wiley   +1 more source

Vitamin B12 and Affective Disorders: A Focus on the Gut-Brain Axis. [PDF]

Alpha Psychiatry
Xu C, Kong L, Mou T, Tang A, Hu S, Lai J.   +5 more
europepmc   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Integrated genomic and transcriptomic approaches reveal oxidative stress adaptation mechanisms in a mesotrione‐resistant Amaranthus tuberculatus biotype

Pest Management Science, Volume 82, Issue 7, Page 6387-6398, July 2026.
Integrated GWAS and transcriptomics in a Canadian waterhemp biotype reveal mesotrione resistance is polygenic and metabolically driven. Significant SNPs and 187 herbicide‐responsive genes point to enhanced redox homeostasis, glutathione‐linked detoxification, lipid/secondary metabolism, and oxidative stress responses. Resistance arises from coordinated,
Martin Laforest, Marianne Bessette, Geneviève Gagnon, Sandra Flores‐Mejia, Brahim Soufiane, Marie‐Claire Goulet, Dominique Michaud   +6 more
wiley   +1 more source

Optimizing metformin therapy in Saudi patients: The crucial role of vitamin B12 monitoring and medication adherence. [PDF]

J Taibah Univ Med Sci
Dahha MB, Alahmadi GA, Dahha BM.
europepmc   +1 more source

Effects of Norbixin on Growth Performance, Immunomodulation, Antioxidant Systems, and Metabolic Alterations in the Oriental River Prawn (Macrobrachium nipponense): An Integrative Analysis

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Dietary norbixin (0.15 g/kg) optimally promotes growth, immunocompetence, antioxidant defence, gut microbial balance, carotenoid accumulation, and overall nutritional quality in Macrobrachium nipponense. ABSTRACT Background Natural carotenoids have gained considerable attention in aquaculture due to their potential to enhance growth performance ...
Mohammad Ettefaghdoost, Hossein Haghighi, Adeleh Haghdoost   +2 more
wiley   +1 more source