Results 1 to 10 of about 661,504 (323)

Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice

Communications Biology, 2021
Fields et al. investigate the impact of vitamin B6 deficiency on islet β-cell proliferation during pregnancy, using vitamin B6-deficient mice. They find that gestational vitamin B6 deficiency decreases serotonin levels in pancreatic islets and reduces β ...
Ashley M. Fields, Kevin Welle, Elaine S. Ho, Clementina Mesaros, Martha Susiarjo   +4 more
doaj   +2 more sources

Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations

Journal of Immunology Research, 2017
The immune system is critical in preventing infection and cancer, and malnutrition can weaken different aspects of the immune system to undermine immunity.
Bingjun Qian, Shanqi Shen, Jianhua Zhang, Pu Jing   +3 more
doaj   +2 more sources

Deprescribing vitamin B6 in a Singapore community hospital [PDF]

BMJ Open Quality
Introduction Vitamin B6 is commonly prescribed in hospitals in Singapore, although the clinical benefits are unclear. The Singapore Health Science Authority released a safety alert on high-dose vitamin B6 and the risk of peripheral neuropathy in May 2023.
Alvin Shao Qiang Ong, Keith Zhong Hui Lee, Yee Shiang Wong, Eng Fui Lim, Dalvin Wan Hong Koh, Hui Yun Soh, Tsui Pik Chan, Gabriel Gerald Wenjun Yee, Yu Xian Loo, Cheryl Yan Fang Tan   +9 more
doaj   +2 more sources

Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation

Journal of Inherited Metabolic Disease, 2020
Sphingosine‐1‐phosphate (S1P) lyase is a vitamin B6‐dependent enzyme that degrades sphingosine‐1‐phosphate in the final step of sphingolipid metabolism.
Piming Zhao, Isaac D Liu, Jeffrey B. Hodgin, Peter I. Benke, Jeremy Selva, Federico Torta, Markus R. Wenk, James A. Endrizzi, O.R. West, Weixing Ou, Emily Tang, Denise Li‐Meng Goh, S K Tay, Hui‐Kim Yap, Alwin Hwai Liang Loh, Nicole Davis Weaver, Bonnie Sullivan, Austin Larson, Megan A. Cooper, Khalid Alhasan, Abdullah Alangari, Suha Salim, Evren Gümüş, Karin Chen, Martin Zenker, Friedhelm Hildebrandt, Julie D. Saba   +26 more
openalex   +3 more sources

Effect of concomitant administration of three different antidepressants with vitamin B6 on depression and obsessive compulsive disorder in mice models

Research in Pharmaceutical Sciences, 2017
Vitamin B6 is a cofactor of various enzymes influencing numerous neurotransmitters in the brain such as norepinephrin, and serotonin. Since these neurotransmitters influence mood, the aim the present work to evaluate the effect of vitamin B6 on ...
Azadeh Mesripour, Valiollah Hajhashemi, Athar Kuchak   +2 more
doaj   +2 more sources

Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.

PLoS ONE, 2018
INTRODUCTION:Animal and clinical studies suggest complementary effects of magnesium and high-dose pyridoxine (vitamin B6) on stress reduction. This is the first randomized trial evaluating the effects of combined magnesium and vitamin B6 supplementation ...
Etienne Pouteau, Marmar Kabir-Ahmadi, Lionel Noah, Andre Mazur, Louise Dye, Juliane Hellhammer, Gisele Pickering, Claude Dubray   +7 more
doaj   +2 more sources

Expert Consensus on Vitamin B6 Therapeutic Use for Patients: Guidance on Safe Dosage, Duration and Clinical Management [PDF]

Drug, Healthcare and Patient Safety
Natalie Schellack,1 Kitiyot Yotsombut,2 Arman Sabet,3 Jalal Nafach,4 Fu Liong Hiew,5 Kongkiat Kulkantrakorn6 1Department of Pharmacology, University of Pretoria, Pretoria, Gauteng, South Africa; 2Department of Pharmacy Practice, Chulalongkorn University,
Schellack N, Yotsombut K, Sabet A, Nafach J, Hiew FL, Kulkantrakorn K   +5 more
doaj   +2 more sources

The Role of Vitamin B6 in Peripheral Neuropathy: A Systematic Review

Nutrients, 2023
Introduction: Vitamin B6 is a water-soluble vitamin that is naturally present in many foods and is accessible in many dietary supplements. The three natural forms are pyridoxine, pyridoxal, and pyridoxamine.
Raman Muhamad, Alexandra Akrivaki, G. Papagiannopoulou, P. Zavridis, P. Zis   +4 more
semanticscholar   +1 more source

Vitamin B6 Inhibits High Glucose-Induced Islet β Cell Apoptosis by Upregulating Autophagy

Metabolites, 2022
Vitamin B6 may alleviate diabetes by regulating insulin secretion and increasing insulin sensitivity, but its mechanism remains to be explored. In this study, vitamin B6-mediated autophagy and high glucose-induced apoptosis were tested to investigate the
Yu Zhang, Xi-an Zhou, Chuxin Liu, Qingwu Shen, Yanyang Wu   +4 more
doaj   +1 more source

Vitamin B6 Competition in the Tumor Microenvironment Hampers Antitumor Functions of NK Cells

Cancer Discovery, 2023
Pancreatic cancer cells deplete vitamin B6 (VB6) in the tumor microenvironment, and supplementation of VB6 or use of agents that block VB6-dependent one-carbon metabolism amplify natural killer cell antitumor immunity and inhibit tumor growth in ...
Chunbo He, Dezhen Wang, S. Shukla, Tuo Hu, Ravi Thakur, Xiao Fu, Ryan J. King, S. S. Kollala, K. S. Attri, Divya Murthy, Nina V. Chaika, Yuki Fujii, Daisy V. Gonzalez, Camila G Pacheco, Yudong Qiu, Pankaj K Singh, J. Locasale, Kamiya Mehla   +17 more
semanticscholar   +1 more source