Results 191 to 200 of about 661,504 (323)

Anti‐Tubercular Drug‐Induced Liver Injury: Current Understanding and Emerging Directions

JGH Open, Volume 10, Issue 1, January 2026.
ABSTRACT Most common adverse effect causing cessation of anti‐tubercular treatment (ATT) is drug‐induced liver injury (DILI) which is unpredictable due to its idiosyncratic nature. ATT is the most common cause of DILI and drug‐induced acute liver failure (ALF) in South East Asia.
Shubham Prasad, Himanshu Narang, Saurabh Kedia, Vineet Ahuja   +3 more
wiley   +1 more source

Vitamin B6 challenge as a tool for detecting ALPL mutations and diagnosing hypophosphatasia. [PDF]

Osteoporos Int
Alvarez S, Ocampo A, Caso PC, Del Real A, Puente N, Vega AI, Riancho-Zarrabeitia L, García-Unzueta MT, Riancho JA.   +8 more
europepmc   +1 more source

Driving Triple‐Bottom‐Line Value: Networks and Impacts in South Africa's Emerging Game Meat Industry

Journal of International Development, Volume 38, Issue 1, Page 1-11, January 2026.
ABSTRACT The current game meat industry value chain analysis focuses primarily on individual firm analysis, production costs and mapping of illegal and legal game meat trade routes. Although there is an attempt to demonstrate the sector's potential contribution to conservation, food security, and livelihood improvement, it remains unclear how the ...
Wiseman Ndlovu, Thapelo Brilliant Lebopa   +1 more
wiley   +1 more source

Vitamin B6 Deficiency May Not Always Present As Microcytic Hypochromic Anemia. [PDF]

Cureus
Nakao S, Nakaseko C, Ishii T, Terai K, Shimizu N.   +4 more
europepmc   +1 more source

Untargeted Metabolomics for Diagnosis, Monitoring, and Understanding the Pathophysiology of Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Inherited metabolic disorders (IMDs) encompass a diverse and expanding group of rare diseases caused by genetic disruptions mainly in metabolic enzymes and transporters. Clinical diagnosis of IMDs presents significant challenges due to phenotypic heterogeneity, nonspecific symptoms, and the limited scope of current targeted biochemical assays ...
Jonathan Martens, Udo F. H. Engelke, Ron A. Wevers, Dirk J. Lefeber, Purva Kulkarni   +4 more
wiley   +1 more source

Vitamin B6 deficiency produces metabolic alterations in Drosophila. [PDF]

Metabolomics
Tesoriere G, Pilesi E, De Rosa M, Giampaoli O, Patriarca A, Spagnoli M, Chiocciolini F, Tramonti A, Contestabile R, Sciubba F, Vernì F.   +10 more
europepmc   +1 more source

Efzimfotase Alfa Improves Respiratory Capacity in Muscle Tissue From a Mouse Model of HPP

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Hypophosphatasia (HPP) is an inherited metabolic disease caused by deficient tissue‐nonspecific alkaline phosphatase (ALP) activity and characterized by skeletal and nonskeletal symptoms, including muscle weakness and fatigue. We hypothesized that mitochondrial respiration is impaired in muscle in HPP, independent of skeletal manifestations ...
Denise Devore, Juan Ruanova, Walter Voegtli, Derek Dunn, John Decker, Maurizio Mazzantini, Vincenzo De Tata, Maria Concetta Scavuzzo, Francesco Conti, Anna Petryk, Maria Luisa Brandi   +10 more
wiley   +1 more source

New Onset Medically Refractory Seizures in an Adult With Parkinson's Disease and Vitamin B6 Deficiency Case Report. [PDF]

Neurohospitalist
Nathan CL, Ghandour D, May J, Bega D, Schuele S.   +4 more
europepmc   +1 more source

Liver Transplantation in PNPO Deficiency: Management Challenges and Biological Lessons

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Pyridox(am)ine 5′ Phosphate Oxidase deficiency (PNPO) presents with refractory epilepsy responsive to treatment with pyridoxal 5′ phosphate (PLP) or pyridoxine. A 15‐year‐old boy with PNPO deficiency and cirrhosis underwent orthotopic liver transplantation for hepatocellular carcinoma without extra‐hepatic disease.
Richard Webster, Bindu Parayil Sankaran, Sushil Bandodkar, Michael Stormon, Gordon Thomas, Albert Shun, David Geoffrey Bowen, Timothy Fielder, Peter Barclay, Youssef Khalil, Philippa Mills, Peter Clayton, Kaustuv Bhattacharya   +12 more
wiley   +1 more source

Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction. [PDF]

NPJ Parkinsons Dis
Wilson EN, Umans J, Swarovski MS, Minhas PS, Mendiola JH, Midttun Ø, Ulvik A, Shahid-Besanti M, Linortner P, Mhatre SD, Wang Q, Channappa D, Corso NK, Tian L, Fredericks CA, Kerchner GA, Plowey ED, Cholerton B, Ueland PM, Zabetian CP, Gray NE, Quinn JF, Montine TJ, Sha SJ, Longo FM, Wolk DA, Chen-Plotkin A, Henderson VW, Wyss-Coray T, Wagner AD, Mormino EC, Aghaeepour N, Poston KL, Andreasson KI.   +33 more
europepmc   +1 more source