Results 1 to 10 of about 923,932 (387)

Kynurenine pathway metabolites: relevant to vitamin B-6 deficiency and beyond. [PDF]

Am J Clin Nutr, 2013
See corresponding article on page 934. Pyridoxal 5′ phosphate (PLP)4, the active form of vitamin B-6, is involved in a wide variety of physiologic processes including gluconeogenesis and the synthesis of sphingolipids and neurotransmitters. It also functions as a cofactor for many enzymes required for amino acid metabolism.
Ciorba MA.
europepmc   +7 more sources

Contribution of vitamin B 6 deficiency to anemia in children on regular hemodialysis. [PDF]

BMC Pediatr
Abstract Background Anemia is prevalent among pediatric patients diagnosed with end-stage kidney disease (ESKD). In addition, erythropoiesis-stimulating agents (ESA) and iron supplementation are considered the cornerstones in the management of anemia.
Atia F, Bazaraa H, Abdelatty Y, Lotfy S, Eryan E.   +4 more
europepmc   +5 more sources

Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects. [PDF]

PLoS ONE, 2013
Marginal deficiency of vitamin B-6 is common among segments of the population worldwide. Because pyridoxal 5'-phosphate (PLP) serves as a coenzyme in the metabolism of amino acids, carbohydrates, organic acids, and neurotransmitters, as well as in ...
Jesse F Gregory, Youngja Park, Yvonne Lamers, Nirmalya Bandyopadhyay, Yueh-Yun Chi, Kichen Lee, Steven Kim, Vanessa da Silva, Nikolas Hove, Sanjay Ranka, Tamer Kahveci, Keith E Muller, Robert D Stevens, Christopher B Newgard, Peter W Stacpoole, Dean P Jones   +15 more
doaj   +4 more sources

Effect of vitamin B-6 deficiency on fasting plasma homocysteine concentrations

The American Journal of Clinical Nutrition, 1992
The catabolism of homocysteine through cystathionine synthesis requires pyridoxal-5'-phosphate, thus the effect of vitamin B-6 deficiency on plasma homocysteine concentrations was evaluated. Total fasting plasma homocysteine concentrations were measured in 11 elderly subjects aged 64.4 +/- 1.7 y (mean +/- SE) who consumed a vitamin B-6-deficient diet ...
Robert M. Russell, Douglas Shepard, James A. Sadowski, Stanley N. Gershoff, Judy D. Ribaya-Mercado, Joshua W. Miller, Jacob Selhub, Elizabeth F. Cochary, Frank D. Morrow   +8 more
semanticscholar   +5 more sources

Response of vitamin B-6 deficiency and the carpal tunnel syndrome to pyridoxine. [PDF]

Proceedings of the National Academy of Sciences, 1982
The specific activities and percentage deficiencies of the glutamic oxaloacetic transaminase of erythrocytes (EGOT) were determined for patients with carpal tunnel syndrome (CTS) diagnosed by clinical examination and electrical conduction data; the EGOT data revealed a severe deficiency of vitamin B-6.
H. A. Schubert, Satoshi Shizukuishi, Satoshi Nishii, John Marion Ellis, Moise Levy, Richard Ulrich, Jan Lewandowski, Karl Folkers   +7 more
semanticscholar   +6 more sources

Effects of Vitamin B-6 Deficiency on Selenium Metabolism in the Rat

The Journal of Nutrition, 1989
Rats were fed for 23 d diets adequate or deficient in vitamin B-6 and containing selenium as either sodium selenite, selenocysteine (SeCys) or selenomethionine (SeMet). They were then injected with 75Se of the same chemical form and killed 2 d later. Tissue deposition of stable and radiotracer selenium and the activity of glutathione peroxidase (GSHPx)
M. A. Beilstein, Philip D. Whanger
semanticscholar   +5 more sources

Underlying Factors Associated with Anemia in Amazonian Children: A Population-Based, Cross-Sectional Study [PDF]

PLoS ONE, 2012
Background: Although iron deficiency is considered to be the main cause of anemia in children worldwide, other contributors to childhood anemia remain little studied in developing countries. We estimated the relative contributions of different factors to
A Levy, Alfredo Mayor, AR Hamel, C Menendez, C Travassos, CA Monteiro, CG Victora, CK Lutter, CM Chaparro, D Filmer, DI Thurnham, DK Bowden, DK Lewis, E Maslova, E Villamor, Eduardo Villamor, FJ López-Antuñano, JCJ Calis, JD Cook, JM Oliveira, K Kalaivani, KE Agho, Kézia K.G. Scopel, L Darrow, LF Gomes, M de Onis, MA Cardoso, Marcelo U. Ferreira, Marly A. Cardoso, ME Cogswell, ML Dreyfuss, MU Ferreira, NR van den Broek, Pascoal T. Muniz, PT Muniz, RA Thurlow, RD Semba, RG Ferreira, RJ Stoltzfus, RJ Stoltzfus, S-R Paricha, S-R Pasricha, Saúde Ministério da, SE Cusick, TG Castro, TH Katsuragawa, TW Gyorkos, Y Balarajan   +47 more
core   +8 more sources

Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients [PDF]

Respiratory Research, 2021
BACKGROUND: Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T lymphocytes.
Anibaldi, Paolo, D'Ascanio, Michela, De Dominicis, Chiara, De Vitis, Claudia, Facchiano, Francesco, Giovagnoli, Simonetta, Innammorato, Marta, Laghi, Andrea, Mancini, Rita, Marcolongo, Adriano, Muscogiuri, Emanuele, Pagliuca, Alessandra, Ricci, Alberto, Sciacchitano, Salvatore, Sposato, Bruno   +14 more
core   +2 more sources

Metformin and vitamin B12 deficiency: What is the evidence? [PDF]

Scripta Medica
The widespread adoption of metformin as a primary therapeutic agent for type 2 diabetes has prompted inquiries into its potential impact on vitamin B 12 (cobalamin) levels and subsequent deficiency. This study aimed to elucidate this complex relationship
Abreu Gonçalves Mariana, Oliveira Peixoto Bruno Daniel, Ramôa Gonçalves Teresa Filipa, Sá Martins Aníbal Alberto   +3 more
core   +2 more sources

Metabolic evidence that deficiencies of vitamin B−12 (cobalamin), folate, and vitamin B−6 occur commonly in elderly people

The American Journal of Clinical Nutrition, 1993
Measurements of the serum concentrations of the metabolites homocysteine, cystathionine, methylmalonic acid, and 2-methylcitric acid, which accumulates when vitamin B-12-, folate-, and vitamin B-6-dependent enzymatic reactions are impaired, should provide a better indication of intracellular deficiency of these vitamins.
H J Naurath, John Lindenbaum, Etienne Joosten, Sally P. Stabler, Robert H. Allen, A Van den berg, R Riezler   +6 more
openaire   +4 more sources