Results 71 to 80 of about 16,093,871 (355)

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials

medRxiv, 2020
Objectives: To assess the overall effect of vitamin D supplementation on risk of acute respiratory infection (ARI), and to identify factors modifying this effect.
David A. Jolliffe, C. Camargo, J. Sluyter, M. Aglipay, J. Aloia, D. Ganmaa, P. Bergman, A. Borzutzky, C. T. Damsgaard, G. Dubnov-Raz, S. Esposito, C. Gilham, A. Ginde, Inbal Golan-Tripto, E. Goodall, C. Grant, C. Griffiths, A. Hibbs, W. Janssens, A. Khadilkar, I. Laaksi, Margaret T. Lee, M. Loeb, J. Maguire, P. Majak, D. Mauger, S. Manaseki-Holland, D. Murdoch, Akio Nakashima, R. Neale, H. Pham, Christine Rake, J. Rees, Jenni Rosendahl, R. Scragg, D. Shah, Yoshiki Shimizu, S. Simpson-Yap, G. Kumar, M. Urashima, A. Martineau   +40 more
semanticscholar   +1 more source

The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease

Translational Neurodegeneration, 2020
In recent years, many studies have investigated the correlations between Parkinson’s disease (PD) and vitamin D status, but the conclusion remains elusive.
Lingling Lv, Xuling Tan, Xinke Peng, Rongrong Bai, Qile Xiao, Ting Zou, Jieqiong Tan, Hainan Zhang, Chunyu Wang   +8 more
doaj   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

An Update on Vitamin D Metabolism

International Journal of Molecular Sciences, 2020
Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver ...
F. Saponaro, A. Saba, R. Zucchi
semanticscholar   +1 more source

The D-lightful vitamin d for health [PDF]

Journal of Medical Biochemistry, 2013
Vitamin D is the sunshine vitamin that is not only important for children's and adults' skeletal health but is also impor­tant for their overall health and wellbeing.
Holick Michael F.
doaj  

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Consensus statement from 2nd International Conference on Controversies in Vitamin D

Reviews in Endocrine & Metabolic Disorders, 2020
The 2nd International Conference on Controversies in Vitamin D was held in Monteriggioni (Siena), Italy, September 11-14, 2018. The aim of this meeting was to address ongoing controversies and timely topics in vitamin D research, to review available data
Andrea Giustina, Robert A. Adler, Neil Binkley, Jens Bollerslev, Jens Bollerslev, Roger Bouillon, Bess Dawson-Hughes, P. Ebeling, David Feldman, A. Formenti, M. Lazaretti-Castro, Claudio Marcocci, R. Rizzoli, C. Sempos, J. Bilezikian   +14 more
semanticscholar   +1 more source

Non-classical effects of vitamin D

Остеопороз и остеопатии, 2018
Since the discovery of vitamin D, interest in role of vitamin D in human body is consistently growing, and there is increasing evidence that vitamin D is not only essential to bone health but may also be involved in physiology of many other tissues. Thus
Ekaterina A. Pigarova, Alexandra A. Petrushkina   +1 more
doaj   +1 more source

Phenotyping Healthcare Use 2–3 Decades Before the First Multiple Sclerosis Demyelinating Event

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Phenotype hospital, physician, and emergency department (ED) visits by diagnoses and specialty up to 29 years pre‐multiple sclerosis (MS) onset versus a matched population without MS. Methods We identified people with MS (PwMS) using population‐based administrative data from Ontario, Canada (1991–2020).
Helen Tremlett, Karl Everett, Colleen J. Maxwell, Feng Zhu, Ayesha Asaf, Ping Li, Kyla A. McKay, Yinshan Zhao, Ruth Ann Marrie   +8 more
wiley   +1 more source