Results 11 to 20 of about 786,573 (309)

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Vitamine D2 ou vitamine D3 ?

La Revue de Médecine Interne, 2008
Resume Propos Pres d’un milliard de personnes dans le monde sont carencees en vitamine D et necessiteraient un apport complementaire. La vitamine D est ainsi disponible comme medicament et nutriment. Elle y est presente sous deux formes : vitamine D2 (ergocalciferol) et vitamine D3 (colecalciferol).
Mistretta, Virginie, Delanaye, Pierre, Chapelle, Jean-Paul, Souberbielle, Jean-Claude, Cavalier, Etienne   +4 more
openaire   +2 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens : a one-year prospective study [PDF]

, 2013
Background Little or no research has determined the effect of vitamin D3 supplementation in conjunction with pharmacological and non-pharmacological approaches in the diabetes mellitus type 2 (DMT2) patients. The objective of this study was to determine
Majed S Alokail, Al-Othman, Abdulaziz, Osama Moharram, Yousef Al-Saleh, Shaun B Sabico, Chrousos, George P., Kumar, Sudhesh, Sabico, Shaun, Abdulaziz Al-Othman, Nasser M Al-Daghri, Sudhesh Kumar, George P Chrousos, Alokail, Majed S., Al-Daghri, Nasser M., Al-Saleh, Yousef, Moharram, Osama, Alkharfy, Khalid M., Khalid M Alkharfy   +17 more
core   +1 more source

Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials. [PDF]

, 2012
Introduction: Vitamin D may affect multiple health outcomes. If so, an effect on mortality is to be expected. Using pooled data from randomized controlled trials, we performed individual patient data (IPD) and trial level meta-analyses to assess ...
Salovaara, K., Smith, H.E., Jackson, Rebecca D, Sanders, Kerrie M., Jacobs, ET, Rebecca D Jackson (16135031), Sanders, KM, Tahir Masud (804313), Jacobs, E.T., JoAnn E Manson (13567339), Robbins, John A., Salovaara, K, Haakon E Meyer (10282121), Rejnmark, Lars, Abrahamsen, Bo, Jackson, Rebecca D., Mosekilde, Leif, Brixen, K., Mosekilde, L., Robbins, JA, Cyrus Cooper (141250), Lars Rejnmark (3752971), Mosekilde, L, Elizabeth T Jacobs (16135028), Bo Abrahamsen (650396), Meyer, Haakon E., Jackson, RD, Alison Avenell (82040), Jacobs, Elizabeth T., Smith, Helen E, Abrahamsen, Bo; id_orcid, Brixen, K, Salovaara, Kari, Manson, Joann E, Torgerson, D., Robbins, J.A., Avenell, A, Robbins, John A, Francis, Roger M., Roger M Francis (7380278), Abrahamsen, B, Masud, T, Jacobs, Elizabeth T, Manson, JoAnn E., Anderson, F., Francis, R.M., Kerrie M Sanders (13488952), Francis, RM, David Torgerson (462403), Masud, T., Helen E Smith (16045475), Abrahamsen, B., Manson, J.E., Cooper, Cyrus, Sanders, K.M., Frazer Anderson (16135022), Meyer, Haakon E, Anderson, F, Torgerson, D, Kari Salovaara (16135025), Meyer, H.E., Rejnmark, L, Francis, Roger M, John A Robbins (8553495), Torgerson, David, Masud, Tahir, Smith, HE, Anderson, Frazer, Cooper, C., Meyer, HE, Kim Brixen (16135034), Jackson, R.D., Smith, Helen E., Cooper, C, Rejnmark, L., Manson, JE, Avenell, Alison, Avenell, A., Brixen, Kim, Leif Mosekilde (349340), Sanders, Kerrie M   +80 more
core   +1 more source

Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients.

New England Journal of Medicine, 2019
BACKGROUND Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients. The potential benefits of vitamin D supplementation in acute critical illness require further study.
A. Ginde, R. Brower, J. Caterino, Lani L. Finck, V. Banner-Goodspeed, C. Grissom, Douglas L. Hayden, C. Hough, R. Hyzy, Akram Khan, J. Levitt, P. Park, N. Ringwood, E. Rivers, W. Self, N. Shapiro, B. Thompson, D. Yealy, D. Talmor   +18 more
semanticscholar   +1 more source

New analogs of vitamin D3 [PDF]

Kidney International, 1999
Calcitriol, the most active metabolite of vitamin D, controls parathyroid gland growth and suppresses the synthesis and secretion of parathyroid hormone (PTH). However, because of its potent effects on intestinal calcium absorption and bone mobilization, calcitriol treatment can induce hypercalcemia, often precluding its use at therapeutic doses ...
Slatopolsky, Eduardo, Dusso, Adriana, Brown, Alex   +2 more
openaire   +2 more sources

Vitamin D3 action within the ovary - an updated review.

Physiological Research, 2020
Vitamin D3 is well-known as a major regulator of calcium and phosphorus homeostasis. A growing body of evidence highlights its crucial role in the regulation of reproductive processes in females.
M. Grzesiak
semanticscholar   +1 more source

The Association between Vitamin D Receptor Expression and Prolonged Overall Survival in Breast Cancer. [PDF]

, 2011
Summary In this study, we analyzed vitamin D receptor (VDR) expression and survival in a breast cancer patient cohort of 82 breast cancer patients. Immunohistochemical analysis was possible in 91.5% of the patients (75/82). Staining was evaluated using
Lenhard, Miriam, Toth, Bettina, Jeschke, Udo, Klaus Friese, Weissenbacher, Tobias, Mayr, Doris, Julia Gallwas, Udo Jeschke, Nina Ditsch, Tobias Weissenbacher, Christian Dannecker, Gallwas, Julia, Dannecker, Christian, Miriam Lenhard, Ditsch, Nina, Friese, Klaus, Doris Mayr, Bettina Toth   +17 more
core   +1 more source

Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2019
Importance In observational studies, higher plasma 25-hydroxyvitamin D (25[OH]D) levels have been associated with improved survival in metastatic colorectal cancer (CRC).
K. Ng, H. Nimeiri, N. McCleary, T. Abrams, M. Yurgelun, J. Cleary, D. Rubinson, D. Schrag, R. Miksad, A. Bullock, Jill N. Allen, D. Zuckerman, E. Chan, J. Chan, B. Wolpin, Michael Constantine, D. Weckstein, Meredith Faggen, C. Thomas, C. Kournioti, C. Yuan, C. Ganser, Brittney Wilkinson, C. Mackintosh, Hui Zheng, B. Hollis, J. Meyerhardt, C. Fuchs   +27 more
semanticscholar   +1 more source