Results 91 to 100 of about 14,972,601 (255)

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Vitamin D status, vitamin D receptor polymorphisms, and risk of cardiometabolic multimorbidity

Nutrition Journal
Background The prevalence of cardiometabolic multimorbidity (CMM) has increased substantially in recent years. Previous studies have established the associations between vitamin D, vitamin D receptor (VDR) polymorphisms, and the risk of individual ...
Jianhua Ma, Pingan Li, Jinqi Wang, Haiping Zhang, Zhiwei Li, Lixin Tao, Xinghua Yang, Yanxia Luo, Xiuhua Guo, Bo Gao   +9 more
doaj   +1 more source

Effects of Vitamin D Deficiency on Proliferation and Autophagy of Ovarian and Liver Tissues in a Rat Model of Polycystic Ovary Syndrome

Biomolecules, 2019
Aim: We aimed to examine the alterations of the insulin signaling pathway, autophagy, nitrative stress and the effect of vitamin D supplementation in the liver and ovaries of vitamin D deficient hyperandrogenic rats.
Krisztina Lajtai, Csilla Terézia Nagy, Róbert Tarszabó, Rita Benkő, Leila Hadjadj, Réka Eszter Sziva, Dóra Gerszi, Bálint Bányai, Péter Ferdinandy, György László Nádasy, Zoltán Giricz, Eszter Mária Horváth, Szabolcs Várbíró   +12 more
doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Correlation of Osteocalcin with Vitamin D Level in Postmenopausal Women Concerning CYP24A1 and VDR Gene Polymorphisms

مجله كليه طب الكندي
Background: Vitamin D is an essential agent in regulating body enzymes due to the wide distribution of vitamin D receptors throughout the body, the site where vitamin D acts. Vitamin D deficiency could be related to many factors.
Noor Mohammed Abdulrahman, Shatha Hussein Ali   +1 more
doaj   +1 more source

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

Proceedings of the Rank Forum on Vitamin D [PDF]

, 2010
The Rank Forum on Vitamin D was held on 2nd and 3rd July 2009 at the University of Surrey, Guildford, UK. The workshop consisted of a series of scene-setting presentations to address the current issues and challenges concerning vitamin D and health, and ...
Lamberg-Allardt, C, C. Nowson, Martineau, A.R., Miles, LM, Lamberg-Allardt, C., Martineau, AR, Darling, A. L., Macdonald, H M, H. M. Macdonald, Berry, J.L., A. L. Darling, Fraser, WD, S. Reddy, M. Kiely, Darling, A.L., de Groot, CPGM, Macdonald, H. M., C. P. G. M. de Groot, S. A. Lanham-New, Prentice, A., Mavroeidi, A.; id_orcid, de Groot, C P G M, Kiely, M., Stone, E M, Fraser, W. D., Miles, L.M., Macdonald, HM, Lanham-New, S. A., Masud, T, De Groot, C. P.G.M., A. Prentice, Francis, R.M., Vieth, R, Francis, RM, K. D. Cashman, Masud, T., E. Hyppönen, Williams, C. M., Boucher, BJ, de Groot, C.P.G.M., Williams, Christine Mary, Mavroeidi, A., Buttriss, J L, de Groot, C. P. G. M., Boucher, B.J., Mavroeidi, A, Reddy, S., A. Mavroeidi, Nowson, C., Stone, E.M., Cooper, C., W. D. Fraser, Fraser, W D, Cooper, C, A. R. Martineau, Boucher, B. J., Berry, J L, E. M. Stone, Buttriss, J.L., C. Cooper, Francis, R. M., Stone, EM, Williams, CM, Reddy, S, Kiely, K, Kiely, M, Hyppönen, E, T. Masud, Martineau, A. R., Francis, R M, Lanham-New, SA, Vieth, R., C. M. Williams, Hyppönen, E., Prentice, A, Macdonald, H.M., B. J. Boucher, M. Ashwell, Williams, M., J. L. Berry, Ashwell, M., Buttriss, JL, Fraser, W.D., L. M. Miles, Miles, L. M., Nowson, C, Stone, E. M., Cashman, K.D., Lanham-New, S A, C. Lamberg-Allardt, Cashman, K D, Berry, J. L., Berry, J.L, Miles, L M, Cashman, K. D., Ashwell, M, Darling, A L, Buttriss, J. L., J. L. Buttriss, Cashman, KD, de Groot, C.P., R. Vieth, Darling, AL, Williams, C.M., Berry, JL, Lanham-New, S.A., Boucher, B J, Groot, C.P.G.M., de, R. M. Francis, Williams, C M, Martineau, A R, Hypöpnen, E., Hyppöpnen, E., Lanham New, S.A.   +113 more
core   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source