Determination of the urinary aglycone metabolites of vitamin K by HPLC with redox-mode electrochemical detection [PDF]
We describe a method for the determination of the two major urinary metabolites of vitamin K as the methyl esters of their agyclone structures, 2-methyl-3-(3-3-carboxymethylpropyl)-1,4-naphthoquinone (5C-side-chain metabolite) and 2-methyl-3-(5-carboxy-3-
Edwards, C +5 more
core +1 more source
Clinical utilization of four-factor prothrombin complex concentrate: a retrospective single center study [PDF]
Objective Four-factor prothrombin complex concentrate (4F-PCC) was approved by the US Food and Drug Administration in 2013 for management of severely bleeding patients on warfarin therapy.
Zaina Naeem +4 more
doaj +1 more source
How we treat bleeding associated with direct oral anticoagulants [PDF]
Direct oral anticoagulants are at least as effective as vitamin K antagonists for the prevention and treatment of thromboembolism. Unfortunately, differently from vitamin K antagonists, they have the great drawback of lacking specific antidotes in the ...
Franchini, Massimo +4 more
core +1 more source
Bacteroides melaninogenicus requires vitamin K for normal growth. Cells incubated in a vitamin K-free medium form defective cell envelopes. Studies with vitamin K-grown “K(+)” and vitamin K-depleted “K(–)” cells showed that [14C]choline and [14C]glycerol
M. Lev, A.F. Milford
doaj +1 more source
Vitamin K policies and midwifery practice: questionnaire survey [PDF]
Objectives: To investigate policies on neonatal vitamin K and their implementation. Design: Two phase postal survey. Setting: United Kingdom. Participants: A 10% random sample of midwives registered with the United Kingdom Central Council for ...
Ansell, P. +3 more
core +2 more sources
Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19
Objectives: Vitamin K deficiency consistently associates with worse clinical outcome in COVID-19 patients. However, whether this is due to increased expenditure during inflammation or poor vitamin K status prior to infection remained unknown. Methods: Dp-
Margot P.J. Visser +5 more
doaj +1 more source
Intake of fat-soluble vitamins in the Belgian population : adequacy and contribution of foods, fortified foods and supplements [PDF]
A key challenge of public health nutrition is to provide the majority of the population with a sufficient level of micronutrients while preventing high-consumers from exceeding the tolerable upper intake level.
de Ridder, Karin +7 more
core +3 more sources
Coagulopathy in Zellweger spectrum disorders: a role for vitamin K [PDF]
Introduction: Zellweger spectrum disorders (ZSDs) are caused by an impairment of peroxisome biogenesis, resulting in multiple metabolic abnormalities. This leads to a range of symptoms, including hepatic dysfunction and coagulopathy. This study evaluated
Engelen, M. (Marc) +6 more
core +1 more source
Biofortification of Chicken Eggs with Vitamin K—Nutritional and Quality Improvements
National nutrition surveys have shown that over half of all adults in Ireland, the United Kingdom (UK), and the United States of America (USA) have low vitamin K intakes.
Siobhan M. O’Sullivan +5 more
doaj +1 more source
Vitamin K deficiency can cause coagulopathy; therefore, supplementation is recommended to prevent intracranial hemorrhage in newborns. Some reports have shown that maternal vitamin K deficiency is associated with intracranial hemorrhage in the fetus ...
Koya Yasuda +6 more
doaj +1 more source

