Results 101 to 110 of about 15,070 (233)

Active pH Modulation by Proton Channel‐Peptide Nucleic Acid Complex for Effective siRNA Endosomal Escape

Small, EarlyView.
A bioinspired siRNA nanocarrier is engineered by integrating an influenza A M2 proton channel with siRNA through a peptide nucleic acid linker on liposome surfaces. Active proton transport amplifies osmotic stress within endosomes, triggering membrane rupture and cytosolic release.
Seongmin Ga, Nam Hyeong Kim, Si Yeon Ryu, Kyeonghyun Kim, Eun Sung Kang, Hayeon Bae, Seungmin Ryu, Suhyeon Kim, Yeontae Jang, Bok‐Soo Lee, Jiyoung Nam, Minah Suh, Jaecheol Lee, Seung‐gu Kang, Jaekyung Hyun, Huong T. Kratochvil, Yong Ho Kim   +16 more
wiley   +1 more source

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika, Meletios P. Nigdelis, Angelos Daniilidis, Erich‐Franz Solomayer, Irene Lambrinoudaki, Efstratios M. Kolibianakis, Dimitrios G. Goulis   +6 more
wiley   +1 more source

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines

Andrology, EarlyView.
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede, George Kanakis, Ewa Rajpert‐De Meyts, Davor Jezek, Ferran Algaba, Gert Dohle, Jolanta Slowikowska‐Hilczer, Sabine Kliesch, Hermann M. Behre, Csilla Krausz, Dimitrios G. Goulis, Niels Jørgensen   +11 more
wiley   +1 more source

The Material Basis of 18th‐Century Meissen Porcelain

Archaeometry, EarlyView.
ABSTRACT In the summer of 1708, the quest for making hard‐paste porcelain from Saxonian clay and other mineral resources succeeded. This was achieved by applying as its essential ingredient newly discovered pure kaolin from Heidelsberg near Aue, western Saxon Ore Mountains.
Robert B. Heimann
wiley   +1 more source

A Newly Discovered Tablet‐Making Facility in Nineveh: Insights From Scientific Analysis

Archaeometry, EarlyView.
ABSTRACT This paper addresses the question of tablet technology in the Neo‐Assyrian capital city of Nineveh. Recent excavations in the lower town of Nineveh by the Iraqi–Italian Archaeological Expedition uncovered an exceptional assemblage of more than 200 tablets from an elite residence that appears to have included a scriptorium.
Mathilde Jean, Michela Spataro, Jonathan Taylor, Gianfranco Ulian, Giovanni Valdré, Gabriele Giacosa, Eleonora Mariani, Nicolò Marchetti   +7 more
wiley   +1 more source

Materials Characterization and Technological Aspects of Hellenistic Grey Ware Lamps From Nysa‐Scythopolis (Israel): Evidence Suggesting Local Production?

Archaeometry, EarlyView.
ABSTRACT Grey ware lamp fragments and a production waster from Tell Iẓṭabba (Israel) were analyzed to determine their manufacturing technology and provenance. These were compared with a light brown‐orange reference fabric from the same site.
Dana Ashkenazi, Anat Cohen‐Weinberger, Achim Lichtenberger, Oren Tal   +3 more
wiley   +1 more source

The Early Upper Palaeolithic open‐air site of Friedrichsdorf‐Seulberg, Germany, in the context of the northern central European Aurignacian

Boreas, EarlyView.
Our knowledge of the Early Upper Palaeolithic occupation in northern central Europe is very limited, and recent research at the open‐air site of Friedrichsdorf‐Seulberg in Hesse, Germany, provides important new information on the Aurignacian. The site is rather small (26.5 m2) and spatial analysis identified a central hearth with two associated ...
Tilman Böckenförde, Gabriele Russo, Neda Rahimzadeh, Felix Bittmann, Nikolitsa Nikolakopoulou, Thomas Terberger   +5 more
wiley   +1 more source

Protein Profile of Multiple Myeloma‐Derived Extracellular Vesicles for the Discovery of Novel Myeloma‐Related Biomarkers

Cancer Science, EarlyView.
Comparison of extracellular vesicles with parental cells through proteomic profiling, followed by an integrated bioinformatic pipeline including disease association and transcriptomic analyses, identifies candidate biomarkers for multiple myeloma. Among these, MIF emerges as a clinically relevant marker, supported by validation in patient samples and ...
Natalia Platonova, Gilda Aiello, Domenica Ronchetti, Valentina Citro, Rosanna Asselta, Lavinia Casati, Domenica Giannandrea, Elisa Taiana, Antonino Neri, Gloria Sini, Elisabetta Calzavara, Mauro Turrini, Alfonsina D'Amato, Raffaella Chiaramonte   +13 more
wiley   +1 more source

The Impact of Vitrification in Artificial Reproductive Technology Programmes

European Medical Journal, 2017
Cryopreservation is an integral part of the current methods of assisted reproductive technology (ART). In the past two decades, slow freezing has been replaced worldwide by vitrification due to its association with improved survival rates and clinical ...
Manish Banker, Aditi Kotdawala, Reena Gupta   +2 more
doaj  

Cryo‐EM structures of multiple‐peptide resistance factor (MprF) from Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
Cryo‐EM analysis of MprF from Pseudomonas aeruginosa reveals a dimeric enzyme, distinct from Rhizobium homologues. The soluble GNAT domain contains a dynamic amphipathic helix (TTH) that adopts different positions in detergent micelle and nanodisc, relative to the membrane.
Shaileshanand Jha, Kutti R. Vinothkumar
wiley   +1 more source