Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice [PDF]
Scientific ReportsTransforming acidic acid coiled-coil protein 3 (TACC3) and cytoskeleton associated protein 5 (cKAP5; or colonic hepatic tumor overexpressed gene, chTOG) are vital for spindle assembly and stabilization initiated through TACC3 Aurora-A kinase interaction.
Calvin Simerly +7 more
doaj +5 more sources
RNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3 to Centromeres and Spindle Poles [PDF]
Advanced SciencePreviously a ring finger protein 20 (RNF20) is found to be essential for meiotic recombination and mediates H2B ubiquitination during spermatogenesis. However, its role in meiotic division is still unknown.
Liying Wang +11 more
doaj +4 more sources
Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation [PDF]
Nature CommunicationsMammalian oocytes are notoriously prone to chromosome segregation errors leading to aneuploidy. The spindle provides the machinery for accurate chromosome segregation during cell division.
Edgar J. Soto-Moreno +13 more
doaj +3 more sources
Meiotic spindle size is a strong indicator of human oocyte quality [PDF]
Reproductive Medicine and Biology, 2018 Purpose To investigate the relationship between the meiotic spindle size in human metaphase II oocytes and embryo developmental potential after intracytoplasmic sperm injection (ICSI).
Hiroyuki Tomari, Toshitaka Horiuchi
exaly +3 more sources
The microtubule-associated protein ASPM regulates spindle assembly and meiotic progression in mouse oocytes. [PDF]
PLoS ONE, 2012 The microtubule-associated protein ASPM (abnormal spindle-like microcephaly-associated) plays an important role in spindle organization and cell division in mitosis and meiosis in lower animals, but its function in mouse oocyte meiosis has not been ...
Xiao-Ling Xu +9 more
doaj +2 more sources
Redundant microtubule crosslinkers prevent meiotic spindle bending to ensure diploid offspring in C. elegans. [PDF]
PLoS Genetics, 2023 Oocyte meiotic spindles mediate the expulsion of ¾ of the genome into polar bodies to generate diploid zygotes in nearly all animal species. Failures in this process result in aneuploid or polyploid offspring that are typically inviable. Accurate meiotic
Wenzhe Li +3 more
doaj +2 more sources
Spatio-temporal requirements of Aurora kinase A in mouse oocyte meiotic spindle building [PDF]
iScienceSummary: Meiotic spindles are critical to ensure chromosome segregation during gamete formation. Oocytes lack centrosomes and use alternative microtubule-nucleation mechanisms for spindle building.
Cecilia S. Blengini +4 more
doaj +2 more sources
Fertility & Reproduction, 2022 Background: The objective of this study was to investigate accurately the effect of the meiotic spindle imaging of human oocytes on their fertilization and embryo development by using the Piezo-ICSI.
Kenichiro Hiraoka +3 more
doaj +1 more source
Kinetochore-independent chromosome poleward movement during anaphase of meiosis II in mouse eggs. [PDF]
PLoS ONE, 2009 Kinetochores are considered to be the key structures that physically connect spindle microtubules to the chromosomes and play an important role in chromosome segregation during mitosis.
Manqi Deng +3 more
doaj +1 more source
#267 : The Spindle Localization ICSI (SL-ICSI) Improves the Fertilization Rate Decreased by Aging
Fertility & Reproduction, 2023 Background and Aims: The position of meiotic spindle in metaphase II oocyte can be different from the underneath of the first polar body. In order to prevent the meiotic spindle damage during ICSI, confirming the position of the spindle is effective.
Hiroomi Kawano +10 more
doaj +1 more source