Results 31 to 40 of about 16,852 (174)
Probing the mechanical architecture of the vertebrate meiotic spindle [PDF]
Nature Methods, 2009 Accurate chromosome segregation during meiosis depends on the assembly of a microtubule-based spindle of proper shape and size. Current models for spindle-size control focus on reaction diffusion-based chemical regulation and balance in activities of motor proteins.
Takeshi, Itabashi +8 more
openaire +2 more sources
Microtubule and Actin Cytoskeletal Dynamics in Male Meiotic Cells of Drosophila melanogaster
Cells, 2022 Drosophila dividing spermatocytes offer a highly suitable cell system in which to investigate the coordinated reorganization of microtubule and actin cytoskeleton systems during cell division of animal cells.
Anna Frappaolo +2 more
doaj +1 more source
PLoS ONE, 2012 The SCF (Skp1-Cul1-F-box) complex contributes to a variety of cellular events including meiotic cell cycle control, but its function during meiosis is not understood well.
Shin-ya Okamoto +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Dynamic changes in microtubules during cell cycle progression are essential for spindle organization to ensure proper segregation of chromosomes. There is growing evidence that post translational modifications of tubulins are the key factors that ...
Hyuk-Joon Jeon, Jeong Su Oh
doaj +1 more source
Small molecule inhibitor of formin homology 2 domains (SMIFH2) reveals the roles of the formin family of proteins in spindle assembly and asymmetric division in mouse oocytes. [PDF]
PLoS ONE, 2015 Dynamic actin reorganization is the main driving force for spindle migration and asymmetric cell division in mammalian oocytes. It has been reported that various actin nucleators including Formin-2 are involved in the polarization of the spindle and in ...
Hak-Cheol Kim +3 more
doaj +1 more source
Kif2a Scales Meiotic Spindle Size in Hymenochirus boettgeri. [PDF]
Curr Biol, 2019 Size is a fundamental feature of biological systems that affects physiology at all levels. For example, the dynamic, microtubule-based spindle that mediates chromosome segregation scales to a wide range of cell sizes across different organisms and cell types.
Miller KE, Session AM, Heald R.
europepmc +7 more sources
Meiotic spindle pushed outward by inward organelle packing. [PDF]
Trends Cell BiolIn Caenorhabditis elegans oocytes, meiotic spindle movement toward the cortex before anaphase depends on kinesin-1. A recent study by Aquino et al. uncovers a novel mechanism whereby the inward organelle packing driven by kinesin-1 excludes the spindle from the center, thereby causing it to be positioned near the cortex.
Xiang X.
europepmc +3 more sources
Reproductive Biology and Endocrinology, 2021 Background In mitotic cells, WAPL acts as a cohesin release factor to remove cohesin complexes from chromosome arms during prophase to allow the accurate chromosome segregation in anaphase.
Changyin Zhou +3 more
doaj +1 more source
Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast
Cell Reports, 2018 Summary: In metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during “open” mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first meiotic division (MI) are “closed,” during which the NE is maintained ...
Ignacio Flor-Parra +5 more
doaj +1 more source
PLoS Genetics, 2020 The requirements for oocyte meiotic cytokinesis during polar body extrusion are not well understood. In particular, the relationship between the oocyte meiotic spindle and polar body contractile ring dynamics remains largely unknown.
Aleesa J Schlientz, Bruce Bowerman
doaj +1 more source