Results 31 to 40 of about 110,429 (168)
Mechanisms of Meiotic Spindle Initiation in Caenorhabditis elegans Oocytes [PDF]
, 2023 Microtubule-based spindle formation is essential to faithful chromosome segregation during cell division. In many animal species, the oocyte meiotic spindle forms without centrosomes (the major microtubule organizing centers), unlike most mitotic cells ...
GONG, TING
core +1 more source
Length-dependent anisotropic scaling of spindle shape [PDF]
, 2014 Spindle length varies dramatically across species and during early development to segregate chromosomes optimally. Both intrinsic factors, such as regulatory molecules, and extrinsic factors, such as cytoplasmic volume, determine spindle length scaling ...
Sébastien Besson +5 more
core +1 more source
PLoS Genetics, 2023 To prevent chromosome mis-segregation, a surveillance mechanism known as the spindle checkpoint delays the cell cycle if kinetochores are not attached to spindle microtubules, allowing the cell additional time to correct improper attachments.
Anne MacKenzie +2 more
doaj +1 more source
Aurora kinase A is essential for meiosis in mouse oocytes.
PLoS Genetics, 2021 The Aurora protein kinases are well-established regulators of spindle building and chromosome segregation in mitotic and meiotic cells. In mouse oocytes, there is significant Aurora kinase A (AURKA) compensatory abilities when the other Aurora kinase ...
Cecilia S Blengini +5 more
doaj +1 more source
Bub3p facilitates spindle checkpoint silencing in fission yeast [PDF]
, 2009 Although critical for spindle checkpoint signaling, the role kinetochores play in anaphase promoting complex (APC) inhibition remains unclear. Here we show that spindle checkpoint proteins are severely depleted from unattached kinetochores in fission ...
Hardwick, Kevin G. +13 more
core +1 more source
Small molecule inhibitor of formin homology 2 domains (SMIFH2) reveals the roles of the formin family of proteins in spindle assembly and asymmetric division in mouse oocytes. [PDF]
PLoS ONE, 2015 Dynamic actin reorganization is the main driving force for spindle migration and asymmetric cell division in mammalian oocytes. It has been reported that various actin nucleators including Formin-2 are involved in the polarization of the spindle and in ...
Hak-Cheol Kim +3 more
doaj +1 more source
The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]
, 2009 Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Michaela Frye +15 more
core +1 more source
PLoS ONE, 2012 The SCF (Skp1-Cul1-F-box) complex contributes to a variety of cellular events including meiotic cell cycle control, but its function during meiosis is not understood well.
Shin-ya Okamoto +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Dynamic changes in microtubules during cell cycle progression are essential for spindle organization to ensure proper segregation of chromosomes. There is growing evidence that post translational modifications of tubulins are the key factors that ...
Hyuk-Joon Jeon, Jeong Su Oh
doaj +1 more source
Microtubule and Actin Cytoskeletal Dynamics in Male Meiotic Cells of Drosophila melanogaster
Cells, 2022 Drosophila dividing spermatocytes offer a highly suitable cell system in which to investigate the coordinated reorganization of microtubule and actin cytoskeleton systems during cell division of animal cells.
Anna Frappaolo +2 more
doaj +1 more source