Bub3p facilitates spindle checkpoint silencing in fission yeast [PDF]
, 2009 Although critical for spindle checkpoint signaling, the role kinetochores play in anaphase promoting complex (APC) inhibition remains unclear. Here we show that spindle checkpoint proteins are severely depleted from unattached kinetochores in fission ...
Hardwick, Kevin G. +13 more
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Meiotic spindle assembly and chromosome segregation in oocytes [PDF]
Journal of Cell Biology, 2016 Oocytes accumulate maternal stores (proteins, mRNAs, metabolites, etc.) during their growth in the ovary to support development after fertilization. To preserve this cytoplasmic maternal inheritance, they accomplish the difficult task of partitioning their cytoplasm unequally while dividing their chromosomes equally.
Isma Bennabi +2 more
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The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function [PDF]
, 2005 During mitosis, the spindle assembly checkpoint (SAC) responds to faulty attachments between kinetochores and the mitotic spindle by imposing a metaphase arrest until the defect is corrected, thereby preventing chromosome missegregation. A genetic screen
Vanoosthuyse, V. +6 more
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The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability [PDF]
, 2009 Myc-induced SUN domain–containing protein (Misu or NSun2) is a nucleolar RNA methyltransferase important for c-Myc–induced proliferation in skin, but the mechanisms by which Misu contributes to cell cycle progression are unknown.
Michaela Frye +15 more
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Structure of the meiotic spindle [PDF]
The Journal of Cell Biology, 2007 ![Graphic][1] Fluorescently labeled tubulin monomers within meiotic spindle filaments are seen as speckles whose motion can be tracked. KAPOOR/MACMILLAN The meiotic spindle is made up of shorter microtubules than previously believed, suggest results from Ge Yang, Gaudenz Danuser (
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Latrunculin A delays anaphase onset in fission yeast by disrupting an ase1-independent pathway controlling mitotic spindle stability [PDF]
, 2008 It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast.
Meadows, John C., Millar, Jonathan B. A.
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A bouquet for meiotic spindle [PDF]
The Journal of Cell Biology, 2007 ![][1] A burst of dissociation (left to right) of telomeres (green) from the SPB (red) may set up meiotic spindles. COOPER/ELSEVIER During early meiosis, telomeres gather at the nuclear membrane, forming a structure of mysterious function dubbed the telomere bouquet.
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Probing the mechanical architecture of the vertebrate meiotic spindle [PDF]
Nature Methods, 2009 Accurate chromosome segregation during meiosis depends on the assembly of a microtubule-based spindle of proper shape and size. Current models for spindle-size control focus on reaction diffusion-based chemical regulation and balance in activities of motor proteins.
Takeshi, Itabashi +8 more
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Microtubule and Actin Cytoskeletal Dynamics in Male Meiotic Cells of Drosophila melanogaster
Cells, 2022 Drosophila dividing spermatocytes offer a highly suitable cell system in which to investigate the coordinated reorganization of microtubule and actin cytoskeleton systems during cell division of animal cells.
Anna Frappaolo +2 more
doaj +1 more source
Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes [PDF]
, 2007 The spindle checkpoint delays anaphase onset until all chromosomes have attached in a bi-polar manner to the mitotic spindle. Mad and Bub proteins are recruited to unattached kinetochores, and generate diffusible anaphase inhibitors.
Rischitor, Patricia E +8 more
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