Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation [PDF]
Nature CommunicationsMammalian oocytes are notoriously prone to chromosome segregation errors leading to aneuploidy. The spindle provides the machinery for accurate chromosome segregation during cell division.
Edgar J. Soto-Moreno +13 more
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Meiotic Spindle Size Is a Strong Indicator of Human Oocyte Quality [PDF]
Reproductive Medicine and Biology, 2018 Purpose To investigate the relationship between the meiotic spindle size in human metaphase II oocytes and embryo developmental potential after intracytoplasmic sperm injection (ICSI).
Hiroyuki Tomari +2 more
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The microtubule-associated protein ASPM regulates spindle assembly and meiotic progression in mouse oocytes. [PDF]
PLoS ONE, 2012 The microtubule-associated protein ASPM (abnormal spindle-like microcephaly-associated) plays an important role in spindle organization and cell division in mitosis and meiosis in lower animals, but its function in mouse oocyte meiosis has not been ...
Xiao-Ling Xu +9 more
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Redundant microtubule crosslinkers prevent meiotic spindle bending to ensure diploid offspring in C. elegans. [PDF]
PLoS Genetics, 2023 Oocyte meiotic spindles mediate the expulsion of ¾ of the genome into polar bodies to generate diploid zygotes in nearly all animal species. Failures in this process result in aneuploid or polyploid offspring that are typically inviable. Accurate meiotic
Wenzhe Li +3 more
doaj +2 more sources
RNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3 to Centromeres and Spindle Poles [PDF]
Advanced SciencePreviously a ring finger protein 20 (RNF20) is found to be essential for meiotic recombination and mediates H2B ubiquitination during spermatogenesis. However, its role in meiotic division is still unknown.
Liying Wang +11 more
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The Meiotic Spindle, Mechanisms of Chromosome Segregation and Aneuploidy in Aging Human Oocytes: An Update Review [PDF]
MedicinaThe meiotic spindle is essential for accurate chromosome segregation during oocyte maturation and fertilization, and its alteration might be considered a major contributor to age-related aneuploidy and reproductive failure.
Romualdo Sciorio +5 more
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Axin-1 Regulates Meiotic Spindle Organization in Mouse Oocytes. [PDF]
PLoS ONE, 2016 Axin-1, a negative regulator of Wnt signaling, is a versatile scaffold protein involved in centrosome separation and spindle assembly in mitosis, but its function in mammalian oogenesis remains unknown.
Xiao-Qin He +12 more
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Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice [PDF]
Scientific ReportsTransforming acidic acid coiled-coil protein 3 (TACC3) and cytoskeleton associated protein 5 (cKAP5; or colonic hepatic tumor overexpressed gene, chTOG) are vital for spindle assembly and stabilization initiated through TACC3 Aurora-A kinase interaction.
Calvin Simerly +7 more
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Spatio-temporal requirements of Aurora kinase A in mouse oocyte meiotic spindle building [PDF]
iScienceSummary: Meiotic spindles are critical to ensure chromosome segregation during gamete formation. Oocytes lack centrosomes and use alternative microtubule-nucleation mechanisms for spindle building.
Cecilia S. Blengini +4 more
doaj +2 more sources
<i>C. elegans</i> kinesin 1 regulates meiotic spindle size. [PDF]
MicroPubl BiolDuring C. elegans female meiosis, kinesin 1 transports yolk granules inward which appears to indirectly drive outward movement of the meiotic spindle to the cortex.
Do R, Aquino A, McNally F.
europepmc +2 more sources