Results 11 to 20 of about 18,808 (211)

Aneuploidy in human eggs: contributions of the meiotic spindle. [PDF]

Biochem Soc Trans, 2021
Human eggs frequently contain an incorrect number of chromosomes, a condition termed aneuploidy. Aneuploidy affects ∼10–25% of eggs in women in their early 30s, and more than 50% of eggs from women over 40. Most aneuploid eggs cannot develop to term upon
Thomas C, Cavazza T, Schuh M.
europepmc   +7 more sources

Bipolar meiotic spindle formation without chromatin. [PDF]

Current Biology, 1998
International audienceEstablishing a bipolar spindle is an early event of mitosis or meiosis. In somatic cells, the bipolarity of the spindle is predetermined by the presence of two centrosomes in prophase. Interactions between the microtubules nucleated
Maro, Bernard, Brunet, Stéphane, Verlhac, Marie-Hélène, Polanski, Zbigniev, Kubiak, Jacek   +4 more
core   +4 more sources

The Telomere Bouquet Controls the Meiotic Spindle [PDF]

Cell, 2007
SummaryBouquet formation, in which telomeres gather to a small region of the nuclear membrane in early meiosis, has been observed in diverse eukaryotes, but the function of the bouquet has remained a mystery.
Tomita, Kazunori, Cooper, Julia Promisel
core   +3 more sources

Translation regulator ballet in meiotic spindle. [PDF]

Cell Cycle, 2017
International audienceThe fine spatial and temporal resolution of translation control can have a rapid and subtle effect on the microenvironment of the cell in comparison with transcriptional regulation.
Cormier P.
europepmc   +6 more sources

Clathrin is essential for meiotic spindle function in oocytes [PDF]

Reproduction, 2010
In the mammalian ovary, oocytes are arrested at prophase of meiosis I until a hormonal stimulus triggers resumption of meiosis. During the subsequent meiotic maturation process, which includes completion of the first meiotic division and formation of the
Biology of Reproductive Cells, Crystal and Structural Chemistry, Wieger Hemrika, Algemeen Onderzoek DGK, Roland A P Romijn, Dep Biochemie en Celbiologie, Bernard A J Roelen, Hemrika, W., van Haeften, T., Roelen, B.A.J., Colenbrander, B., Sub Crystal and Structural Chemistry, Dep Gezondheidszorg Landbouwhuisdieren, Romijn, R.A.P., Theo van Haeften, Ben Colenbrander, Stoorvogel, W., Willem Stoorvogel, Hölzenspies, J.J., Jurriaan J Hölzenspies   +19 more
core   +5 more sources

Assembly and Positioning of the Oocyte Meiotic Spindle [PDF]

Annual Review of Cell and Developmental Biology, 2018
Fertilizable eggs develop from diploid precursor cells termed oocytes. Once every menstrual cycle, an oocyte matures into a fertilizable egg in the ovary.
Mogessie, Binyam, Schuh, Melina, Scheffler, K., Mogessie, B., Scheffler, Kathleen, Schuh, M. ; https://orcid.org/   +5 more
core   +7 more sources

Axin-1 Regulates Meiotic Spindle Organization in Mouse Oocytes. [PDF]

PLoS ONE, 2016
Axin-1, a negative regulator of Wnt signaling, is a versatile scaffold protein involved in centrosome separation and spindle assembly in mitosis, but its function in mammalian oogenesis remains unknown.
Xiao-Qin He, Yue-Qiang Song, Rui Liu, Yu Liu, Fei Zhang, Zhen Zhang, Yu-Ting Shen, Lin Xu, Ming-Huang Chen, Ya-Long Wang, Bai-Hui Xu, Xiang-Jun Yang, Hai-Long Wang   +12 more
doaj   +2 more sources

A computational model predicts Xenopus meiotic spindle organization [PDF]

Journal of Cell Biology, 2010
The metaphase spindle is a dynamic bipolar structure crucial for proper chromosome segregation, but how microtubules (MTs) are organized within the bipolar architecture remains controversial.
Nédélec, François, François Nédélec, Heald, Rebecca, Loughlin, Rose, Rebecca Heald, Rose Loughlin   +5 more
core   +5 more sources

Timing of ICSI with Respect to Meiotic Spindle Status. [PDF]

Int J Mol Sci, 2022
The aim of this study was to evaluate the efficiency of using meiotic spindle (MS) visibility and relative position to the polar body (PB) as indicators of oocyte maturation in order to optimize intracytoplasmic sperm injection (ICSI) timing. This was a cohort study of patients younger than 40 years with planned ICSI, the timing of which was determined
Tepla O, Topurko Z, Jirsova S, Moosova M, Fajmonova E, Cabela R, Komrskova K, Kratochvilova I, Masata J.   +8 more
europepmc   +3 more sources

Meiotic Spindle: Sculpted by Severing [PDF]

Current Biology, 2006
Katanin is a conserved AAA ATPase with the ability to sever microtubules, but its biological function in animal cells has been obscure. A recent study using electron tomography has found that katanin stimulates the production of microtubules in the meiotic spindles of Caenorhabditis elegans oocytes.
Ribbeck, Katharina, Mitchison, Timothy J.   +1 more
openaire   +2 more sources