Results 11 to 20 of about 16,852 (174)
Timing of ICSI with Respect to Meiotic Spindle Status. [PDF]
Int J Mol Sci, 2022 The aim of this study was to evaluate the efficiency of using meiotic spindle (MS) visibility and relative position to the polar body (PB) as indicators of oocyte maturation in order to optimize intracytoplasmic sperm injection (ICSI) timing. This was a cohort study of patients younger than 40 years with planned ICSI, the timing of which was determined
Tepla O +8 more
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Aneuploidy in human eggs: contributions of the meiotic spindle. [PDF]
Biochem Soc Trans, 2021 Human eggs frequently contain an incorrect number of chromosomes, a condition termed aneuploidy. Aneuploidy affects ∼10–25% of eggs in women in their early 30s, and more than 50% of eggs from women over 40. Most aneuploid eggs cannot develop to term upon fertilization, making aneuploidy in eggs a leading cause of miscarriages and infertility.
Thomas C, Cavazza T, Schuh M.
europepmc +6 more sources
Meiotic Spindle: Sculpted by Severing [PDF]
Current Biology, 2006 Katanin is a conserved AAA ATPase with the ability to sever microtubules, but its biological function in animal cells has been obscure. A recent study using electron tomography has found that katanin stimulates the production of microtubules in the meiotic spindles of Caenorhabditis elegans oocytes.
Ribbeck, Katharina +1 more
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Assembly and Positioning of the Oocyte Meiotic Spindle [PDF]
Annual Review of Cell and Developmental Biology, 2018 Fertilizable eggs develop from diploid precursor cells termed oocytes. Once every menstrual cycle, an oocyte matures into a fertilizable egg in the ovary. To this end, the oocyte eliminates half of its chromosomes into a small cell termed a polar body. The egg is then released into the Fallopian tube, where it can be fertilized.
Mogessie, Binyam +2 more
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Meiotic Spindle Has a Soft Spot [PDF]
Developmental Cell, 2019 The spindle relies on forces exerted by microtubules and motor proteins to align and segregate chromosomes. In this issue of Developmental Cell, Takagi et al. (2019) show that meiotic spindle microtubules respond differently to forces at different spindle locations, depending on microtubule organization and motor proteins that crosslink them.
Simunić, Juraj, Tolić, Iva M.
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Vitrification of In vitro-matured Oocytes: Effects of meiotic spindle morphology on clinical outcome
Reproductive and Developmental Medicine, 2020 Objective: The meiotic spindle controls chromosome movement and mediates various functions essential for fertilization and early postfertilization events. This study aimed to examine whether vitrification causes meiotic damage in vitro- matured metaphase
Rui-Huan Gu +8 more
doaj +1 more source
The Telomere Bouquet Controls the Meiotic Spindle [PDF]
Cell, 2007 Bouquet formation, in which telomeres gather to a small region of the nuclear membrane in early meiosis, has been observed in diverse eukaryotes, but the function of the bouquet has remained a mystery. Here, we demonstrate that the telomere bouquet plays a crucial role in controlling the behavior of the fission yeast microtubule-organizing center ...
Tomita, Kazunori, Cooper, Julia Promisel
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TACC3 Is Important for Correct Progression of Meiosis in Bovine Oocytes. [PDF]
PLoS ONE, 2015 Transforming acidic coiled-coil (TACC) proteins are key players during mitosis via stabilization of the spindle. The roles of TACCs during meiosis are however less clear. We used bovine oocytes to study the expression and function of TACC3 during meiosis.
Mahdi Mahdipour +6 more
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Translation regulator ballet in meiotic spindle. [PDF]
Cell Cycle, 2017 The fine spatial and temporal resolution of translation control can have a rapid and subtle effect on the microenvironment of the cell in comparison with transcriptional regulation. Mammalian oocyte represents a relevant model that allows addressing the spatial control of translation during meiotic maturation.
Cormier P.
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Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes
Cell Division, 2020 Background Microtubule organization is essential for bipolar spindle assembly and chromosome segregation, which contribute to genome stability. Kinesin-5 Eg5 is known to be a crucial regulator in centrosome separation and spindle assembly in mammalian ...
Zhen-Yu She +7 more
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