Results 21 to 30 of about 18,808 (211)
Vitrification of In vitro-matured Oocytes: Effects of meiotic spindle morphology on clinical outcome
Reproductive and Developmental Medicine, 2020 Objective: The meiotic spindle controls chromosome movement and mediates various functions essential for fertilization and early postfertilization events. This study aimed to examine whether vitrification causes meiotic damage in vitro- matured metaphase
Rui-Huan Gu +8 more
doaj +1 more source
Meiotic Spindle Has a Soft Spot [PDF]
Developmental Cell, 2019 The spindle relies on forces exerted by microtubules and motor proteins to align and segregate chromosomes. In this issue of Developmental Cell, Takagi et al. (2019) show that meiotic spindle microtubules respond differently to forces at different spindle locations, depending on microtubule organization and motor proteins that crosslink them.
Simunić, Juraj, Tolić, Iva M.
openaire +5 more sources
TACC3 Is Important for Correct Progression of Meiosis in Bovine Oocytes. [PDF]
PLoS ONE, 2015 Transforming acidic coiled-coil (TACC) proteins are key players during mitosis via stabilization of the spindle. The roles of TACCs during meiosis are however less clear. We used bovine oocytes to study the expression and function of TACC3 during meiosis.
Mahdi Mahdipour +6 more
doaj +1 more source
Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes
Cell Division, 2020 Background Microtubule organization is essential for bipolar spindle assembly and chromosome segregation, which contribute to genome stability. Kinesin-5 Eg5 is known to be a crucial regulator in centrosome separation and spindle assembly in mammalian ...
Zhen-Yu She +7 more
doaj +1 more source
Katanin controls mitotic and meiotic spindle length [PDF]
The Journal of Cell Biology, 2006 Accurate control of spindle length is a conserved feature of eukaryotic cell division. Lengthening of mitotic spindles contributes to chromosome segregation and cytokinesis during mitosis in animals and fungi. In contrast, spindle shortening may contribute to conservation of egg cytoplasm during female meiosis.
McNally, Karen +3 more
openaire +2 more sources
OsMTOPVIB is required for meiotic bipolar spindle assembly [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance The organization of microtubules into a bipolar spindle is essential for chromosome segregation. Both centrosome and chromatin-dependent spindle assembly mechanisms are well studied in animals; however, the mechanism of bipolar spindle assembly in plant meiosis remains unclear.
Zhihui Xue +10 more
openaire +2 more sources
Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes. [PDF]
PLoS ONE, 2008 Formation of female gametes requires acentriolar spindle assembly during meiosis. Mitotic spindles organize from centrosomes and via local activation of the RanGTPase on chromosomes.
Stéphane Brunet +7 more
doaj +1 more source
Length-dependent anisotropic scaling of spindle shape [PDF]
, 2014 Spindle length varies dramatically across species and during early development to segregate chromosomes optimally. Both intrinsic factors, such as regulatory molecules, and extrinsic factors, such as cytoplasmic volume, determine spindle length scaling ...
Sébastien Besson +5 more
core +1 more source
PLoS Genetics, 2023 To prevent chromosome mis-segregation, a surveillance mechanism known as the spindle checkpoint delays the cell cycle if kinetochores are not attached to spindle microtubules, allowing the cell additional time to correct improper attachments.
Anne MacKenzie +2 more
doaj +1 more source
Aurora kinase A is essential for meiosis in mouse oocytes.
PLoS Genetics, 2021 The Aurora protein kinases are well-established regulators of spindle building and chromosome segregation in mitotic and meiotic cells. In mouse oocytes, there is significant Aurora kinase A (AURKA) compensatory abilities when the other Aurora kinase ...
Cecilia S Blengini +5 more
doaj +1 more source