Exclusion of the endoplasmic reticulum from the <i>C. elegans</i> meiotic spindle controls spindle size. [PDF]
MicroPubl BiolThe nuclear envelope is composed of sheet-like ER that separates chromatin from tubulin during interphase. During oocyte maturation in C. elegans , a fenestrated envelope of sheet-like ER continues to envelope the meiotic spindle through metaphase I.
Aquino A, McNally F.
europepmc +2 more sources
Fertility & Reproduction, 2022 Background: The objective of this study was to investigate accurately the effect of the meiotic spindle imaging of human oocytes on their fertilization and embryo development by using the Piezo-ICSI.
Kenichiro Hiraoka +3 more
doaj +1 more source
Kif2a Scales Meiotic Spindle Size in Hymenochirus boettgeri [PDF]
Current Biology, 2019 Rebecca Heald, Kelly Miller
exaly +2 more sources
Aneuploidy in human eggs: contributions of the meiotic spindle. [PDF]
Biochem Soc Trans, 2021 Human eggs frequently contain an incorrect number of chromosomes, a condition termed aneuploidy. Aneuploidy affects ∼10–25% of eggs in women in their early 30s, and more than 50% of eggs from women over 40. Most aneuploid eggs cannot develop to term upon
Thomas C, Cavazza T, Schuh M.
europepmc +2 more sources
Kinetochore-independent chromosome poleward movement during anaphase of meiosis II in mouse eggs. [PDF]
PLoS ONE, 2009 Kinetochores are considered to be the key structures that physically connect spindle microtubules to the chromosomes and play an important role in chromosome segregation during mitosis.
Manqi Deng +3 more
doaj +1 more source
#267 : The Spindle Localization ICSI (SL-ICSI) Improves the Fertilization Rate Decreased by Aging
Fertility & Reproduction, 2023 Background and Aims: The position of meiotic spindle in metaphase II oocyte can be different from the underneath of the first polar body. In order to prevent the meiotic spindle damage during ICSI, confirming the position of the spindle is effective.
Hiroomi Kawano +10 more
doaj +1 more source
Vitrification of In vitro-matured Oocytes: Effects of meiotic spindle morphology on clinical outcome
Reproductive and Developmental Medicine, 2020 Objective: The meiotic spindle controls chromosome movement and mediates various functions essential for fertilization and early postfertilization events. This study aimed to examine whether vitrification causes meiotic damage in vitro- matured metaphase
Rui-Huan Gu +8 more
doaj +1 more source
TACC3 Is Important for Correct Progression of Meiosis in Bovine Oocytes. [PDF]
PLoS ONE, 2015 Transforming acidic coiled-coil (TACC) proteins are key players during mitosis via stabilization of the spindle. The roles of TACCs during meiosis are however less clear. We used bovine oocytes to study the expression and function of TACC3 during meiosis.
Mahdi Mahdipour +6 more
doaj +1 more source
Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes
Cell Division, 2020 Background Microtubule organization is essential for bipolar spindle assembly and chromosome segregation, which contribute to genome stability. Kinesin-5 Eg5 is known to be a crucial regulator in centrosome separation and spindle assembly in mammalian ...
Zhen-Yu She +7 more
doaj +1 more source
Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes. [PDF]
PLoS ONE, 2008 Formation of female gametes requires acentriolar spindle assembly during meiosis. Mitotic spindles organize from centrosomes and via local activation of the RanGTPase on chromosomes.
Stéphane Brunet +7 more
doaj +1 more source