Results 81 to 90 of about 14,521 (206)

The Oocyte/Antral Follicle Count Index: Does Maximizing Oocyte Yield Translate into Better Assisted Reproductive Technology Outcomes?

Journal of Ultrasound in Medicine, EarlyView.
Objectives Whether aspiration of more oocytes than the antral follicle count (AFC) is beneficial for the current and future products of assisted reproductive technologies (ART) cycles. Methods Data of the first oocyte aspiration for intracytoplasmic sperm injection performed between 2018 and 2022 in attempt to conceive (ICSI, n = 399) or for planned ...
Shir Danieli‐Gruber, Onit Sapir, Dan Netanely, Avital Wertheimer, Avi Ben‐Haroush, Eran Altman, Tzippy Shochat, Yoel Shufaro   +7 more
wiley   +1 more source

Polyglycerol‐Based Lipids: A Next‐Generation Alternative to PEG in Lipid Nanoparticles for Advanced Drug Delivery Systems

Macromolecular Rapid Communications, EarlyView.
Linear polyglycerol is proposed as a PEG‐alternative in mRNA‐loaded lipid nanoparticles to limit activation of anti‐PEG antibodies and reduce immunogenicity. Resulting nanoparticles may provide similar gene delivery capabilities, while preventing binding of anti‐PEG antibodies compared to PEGylated counterparts.
Yara Ensminger, Rashmi Rashmi, Michael Karimov, Gideon Nölte, Markus Hafke, Ann‐Cathrin Schmitt, David Díaz‐Oviedo, Johannes Köbberling, Rainer Haag   +8 more
wiley   +1 more source

Vitrification of Heart Valve Tissues

, 2014
Application of the original vitrification protocol used for pieces of heart valves to intact heart valves has evolved over time. Ice-free cryopreservation by Protocol 1 using VS55 is limited to small samples where relatively rapid cooling and warming rates are possible.
Kelvin G M, Brockbank, Zhenzhen, Chen, Elizabeth D, Greene, Lia H, Campbell   +3 more
openaire   +4 more sources

Hydrogels Incorporating Donor–Acceptor Stenhouse Adducts as a Platform for Photoinduced, On‐Off Switchable Release of Small Molecule Cargos

Macromolecular Rapid Communications, EarlyView.
Donor–acceptor Stenhouse aDdducts (DASAs) are known for their photoinduced tautomerization, which, when conjugated to block copolymers, can self‐assemble into tuneable polymersomes. These DASA‐polymersomes are being investigated for light‐controlled cargo release in biomedical applications.
Tristan N. Dell, Ana Cammack‐Najera, Rea Tresa, Farzina Matubbar, Beyzanur Kaya, Uthaya Lathan, Mohamed Chami, Ray G. DiNardi, Omar Rifaie‐Graham, Jonathan P. Wojciechowski, Molly M. Stevens   +10 more
wiley   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

CO2‐Assisted Foaming of PLA–Cellulose Acetate Blends for Peat‐Free Horticultural Substrates

Polymer Engineering &Science, EarlyView.
Engineered porous substrate facilitating seed incorporation, water retention, and plant growth. ABSTRACT This study investigates carbon dioxide assisted (CO2) foaming of polylactic acid (PLA)–cellulose acetate (CA) blends to develop biodegradable substrates for horticultural applications.
Kaleum Meaney, Ke Gong, Yvonne Cortese, Yin Zhu, Lena Madden, Michael Gaffney, Declan Devine, Crevan O'Donnell, Yuanyuan Chen   +8 more
wiley   +1 more source

Robust β‐myrcene block copolymer elastomeric vitrimers

Polymer International, EarlyView.
Myrcene‐based vitrimeric elastomers were compared: statistical (poly(styrene‐stat‐myrcene‐stat‐AAEMA)] versus ‘hard–soft’ diblock (poly(styrene)‐block‐poly(myrcene‐co‐AAEMA)). The diblock's ability to anchor the glassy poly(styrene) blocks in a self‐assembled microstructure was effective – leading to four times higher tensile stress and ten times ...
Chong Yang Du, Farhad Asempour, Milan Marić   +2 more
wiley   +1 more source

Ionogel Actuators: A Review

SmartBot, EarlyView.
Ionogels dynamically and functionally couple ionic liquids with polymer networks, enabling multiscale programmable deformation and motion under electrical, magnetic, optical, thermal, humidity, and chemical stimuli. This article systematically elucidates the constituent components, structural design, and multiscale actuation mechanisms of ionogel ...
Dezhou Cao, Dongqing He, Yuanxiang Zhao, Dongdong Jin, Jiaheng Zhang, Wei Wang   +5 more
wiley   +1 more source

Innovative γ‐Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery

Small, EarlyView.
Identified through multi‐stage selection process, a formulation combining γ‐oryzanol and DLin‐KC2‐DMA, termed as OryKL, demonstrates unique nano‐structural features, highly efficient mRNA transfection and functional integrity during long‐term storage, enables broad biodistribution and distinct cell tropism following intravenous administration with no ...
Pengkai Shi, Haikun Liu, Ahmed Refaat, Hung Nguyen, Anne Nguyen, Kaiting Miao, Yuyang Song, Sylvain Trépout, Rico F. Tabor, Liliana de Campo, Karlheinz Peter, Mark Louis P. Vidallon, Xiaowei Wang   +12 more
wiley   +1 more source

Vitrification of human blastocysts for couples undergoing assisted reproduction: an updated review

Frontiers in Cell and Developmental Biology
Over the past 40 years there has been a worldwide critical change in the field of assisted reproduction technology (ART), leading to the increased application of single blastocyst transfer, which is extremely important to avoid the risks of multiple ...
Romualdo Sciorio, Luca Tramontano, Gerard Campos, Gerard Campos, Pier Francesco Greco, Giuseppe Mondrone, Anna Surbone, Ermanno Greco, Ermanno Greco, Riccardo Talevi, Nicola Pluchino, Steven Fleming   +11 more
doaj   +1 more source