Роль поліморфізмів поодиноких нуклеотидів гена вітамін К епоксид редуктази в розвитку мультифакторіальних хвороб [PDF]
, 2012 Наук.
Dubovyk, Yevhen Ivanovych +3 more
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Characterization of the VKORC1 and CYP2C9 genotypes v5
, 2023 Vitamin K antagonists (e.g. warfarin) are anticoagulants which represent widely prescribed drugs for prevention and treatment of thromboembolic disorders. Warfarin's molecular target is vitamin K epoxide reductase enzyme and its metabolism is performed by the cytochrome P-450 2C9 enzyme, both of which are encoded by polymorphic genes - vitamin K ...
Mirsada Causevic, Honours BSc, PhD +1 more
openaire +1 more source
Romanian Journal of Laboratory Medicine, 2014 Scop: Această cercetare are drept scop stabilirea unei corelaţii genotip-fenotip la pacienţii trataţi cu acenocumarol şi studierea factoriilor genetici (polimorfismele VKORC1 şi CYP2C9), care ar putea influenţa valorile INR în timpul iniţierii terapiei ...
Militaru Florentina Claudia +5 more
doaj +1 more source
The allele frequency of CYP2C9 and VKORC1 in the Southern Khorasan population
Research in Pharmaceutical Sciences, 2017 The genetic factors are determinants in required dosage changes of warfarin among which are polymorphisms of CYP2C9 and VKORC1 genes. The present study aimed to determine the allele and genotype frequency of CYP2C9 and VKORC1 genes in Birjand population.
Fariba Emadian Razavi +3 more
doaj +1 more source
Pharmacogenomics in cardiovascular disorders: Steps in approaching personalized medicine in cardiovascular medicine [PDF]
, 2009 Christopher Barone, Shaymaa S Mousa, Shaker A MousaThe Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY, USAAbstract: Some of the most commonly prescribed medications are those for cardiovascular maladies. The
Christopher Barone +2 more
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Acta Medica BulgaricaAcenocoumarol, a 4-hydroxycoumarin derivative, is widely prescribed for the primary and secondary prevention of thromboembolic disorders. Maintenance dosing of acenocoumarol is significantly influenced by polymorphic variants in the CYP2C9 and VKORC1 ...
Tzveova R. +6 more
doaj +1 more source
Clinical and Translational Science, 2019 Alaska Native and American Indian (AN/AI) people have unique pharmacogene variation that may affect warfarin disposition and therapeutic response. We performed targeted genotyping for cytochrome P450 (CYP)2C9, vitamin K epoxide oxidase reductase complex ...
Lindsay M. Henderson +13 more
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Genetic factors associated with patient-specific warfarin dose in ethnic Indonesians
BMC Medical Genetics, 2011 Background CYP2C9 and VKORC1 are two major genetic factors associated with inter-individual variability in warfarin dose. Additionally, genes in the warfarin metabolism pathway have also been associated with dose variance.
Utama Andi +6 more
doaj +1 more source
VKORC1 sequence variants associated with resistance to anticoagulant rodenticides in Irish populations of Rattus norvegicus and Mus musculus domesticus [PDF]
, 2018 While resistance to anticoagulant rodenticides is known to occur in many European populations of Norway rat and house mouse, to-date no data is available on the occurrence in Ireland of such resistance.
Clegg, Tracy +7 more
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Вивчення статевих особливостей розподілу алельних варіантів гена кісткового морфометричного протеїну-2 (ВМР-2) за Ser37Ala поліморфізмом у хворих із гострим коронарним синдромом [PDF]
, 2015 Кістковий морфогенетичний протеїн (ВМР-2) – важливий чинник регуляції кальцієвого гомеостазу – один із представників сімейства кісткових морфогенетичних протеїнів, що належить до групи факторів росту і цитокінів.
Harbuzova, Viktoriia Yuriivna +6 more
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