Results 191 to 200 of about 7,461 (205)

Speculations on vitamin K, VKORC1 genotype and autism

Medical Hypotheses, 2016
Humans vary in the gene that encodes for Vitamin K epoxide reductase complex (VKORC1). Recent research has documented the protective effect of Vitamin K on neural cells and its role in maintaining normal neural development. Of interest, specific neural effects of Vitamin K overlap with key brain development aberrations, including those associated with ...
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A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance

Blood, 2006
Abstract CYP2C9 and VKORC1 genetic variants are associated with low and intermediate warfarin dose requirements, but markers of high doses are less well characterized. We analyzed the VKORC1 coding sequence and known CYP2C9 and VKORC1 polymorphisms in 15 selected warfarin-resistant (dose, 80 to 185 mg/wk) and 8 warfarin-sensitive ...
Ronen, Loebstein, Ilana, Dvoskin, Hillel, Halkin, Manuela, Vecsler, Aharon, Lubetsky, Gideon, Rechavi, Ninette, Amariglio, Yoram, Cohen, Gie, Ken-Dror, Shlomo, Almog, Eva, Gak   +10 more
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VKORC1 C1173TandVKORC1 G-1639AGene Polymorphisms in Turkish Behçet’s Patients with Ocular and Non-ocular Involvement

Ophthalmic Genetics, 2013
Behçet's disease (BD) is a multisystemic vasculitis with unknown etiology. Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the key enzyme in the formation of active vitamin K that is a cofactor of various coagulation factors. Polymorphisms of the VKORC1 may affect the levels of active forms of vitamin K-dependent coagulation proteins and the ...
Helin Deniz, Demir, Hüseyin, Ortak, Şemsettin, Şahin, Ömer, Ateş, Ismail, Benli, Ahmet, İnanır   +5 more
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Identification of VKORC1 genotype leading to resistance to tecarfarin

The Journal of Clinical Pharmacology, 2014
The VKORC1 gene codes for the VKORC1 enzyme that is responsible for the reduction of vitamin K epoxide into vitamin K. VKORC1 enzyme is the target of vitamin K antagonists (VKA). The use of VKA in human medicine is difficult because of inter-individual variability in VKA requirements. This variability is partly due to basic physiological parameters but
Benjamin, Matagrin, Adrien, Montagut-Romans, Marlene, Damin, Lemaire, Marc, Florence, Popowycz, Benoit, Etienne, Lattard, Virginie   +6 more
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Influence of VKORC1 Haplotypes on Cardiovascular Disease

2008
Coronary heart disease is one of the leading causes of morbidity and mortality in Europe. Atherogenesis and vascular calcification have been linked to vitamin K and the downstream pathways of vitamin K dependant proteins acting in blood coagulation and calcium metabolism.
M. Watzka, A. Nebel, N. E. El Mokhtari, B. Ivandic, J. Müller, St. Schreiber, J. Oldenburg   +6 more
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CYP2C9, CYP4F2, VKORC1 Gene Polymorphism in Buryat Population

Russian Journal of Genetics, 2020
The allele and genotype frequency distribution at polymorphic loci rs1799853 (430C>T) and rs1057910 (A1075C) of the CYP2C9 gene, rs2108622 (1347C>T) of the CYP4F2 gene, and rs9923231 (1639G>A) of the VKORC1 gene in the Buryat population was examined. The study involved 197 volunteers living in the Republic of Buryatia: 124 woman and 73 men, average age
A. Yu. Sambyalova, T. A. Bairova, E. V. Belyaeva, O. A. Ershova, D. S. Sargaeva, S. I. Kolesnikov   +5 more
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VKORC1 Haplotypes in Five East-Asian Populations and Indians

Pharmacogenomics, 2009
Warfarin, a widely prescribed oral anticoagulant, is used for the prevention of thromboembolism. Several polymorphisms in VKORC1 have been shown to be associated with warfarin dose requirements. The frequencies of these VKORC1 polymorphisms display population differences; however, this has not been examined in many populations.
Ming Ta Michael, Lee, Chien-Hsiun, Chen, Hui-Ping, Chuang, Liang-Suei, Lu, Ching-Heng, Chou, Ying-Ting, Chen, Chih-Yang, Liu, Ming-Shien, Wen, Jang-Jih, Lu, Chi-Feng, Chang, Jer-Yuarn, Wu, Yuan-Tsong, Chen   +11 more
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Population variation in VKORC1 haplotype structure

Journal of Thrombosis and Haemostasis, 2006
S, Marsh, C R, King, R M, Porche-Sorbet, T J, Scott-Horton, C S, Eby   +4 more
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VKORC1-Genetik und Marcumar-Dosisfindung

Aktuelle Neurologie, 2008
M.L Arnold, M.T Di Mascio, M Kloss, C Grond-Ginsbach, P.A Ringleb, C Lichy   +5 more
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Farmakogentika varfarina: polimorfizam VKORC1 i CYP2CP

2010
Velika varijabilnost u postizanju optimalne doze varfarina među bolesnicima može biti povezana s funkcionalnim varijantama gena koji utječu na metabolizam (CYP2C9) i njegovo mjesto djelovanja (VKORC1). Polimorfizmi jednog nukleotida koji rezultiraju promjenama u aminokiselinskom slijedu u citokroma P450 i na genu VKORC1, bili su u centru istraživanja ...
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