Results 91 to 100 of about 66,180 (284)

VLDL hydrolysis by LPL activates PPAR-α through generation of unbound fatty acids

Journal of Lipid Research, 2010
Recent evidence suggests that lipoproteins serve as circulating reservoirs of peroxisomal proliferator activated receptor (PPAR) ligands that are accessible through lipolysis.
Maxwell A. Ruby, Benjamin H Goldenson, Gabriela Orasanu, T. Johnston, J. Plutzky, R. Krauss   +5 more
semanticscholar   +1 more source

Genetic Determinants of the Familial Hypercholesterolaemia Phenotype

Annals of Human Genetics, EarlyView.
ABSTRACT Individuals with familial hypercholesterolaemia (FH) have severely elevated plasma concentrations of low‐density lipoprotein cholesterol (LDL‐C) from birth and as a consequence have an elevated morbidity and mortality due to the development of coronary heart disease (CHD).
Steve Eric Humphries, Marta Futema
wiley   +1 more source

Resistance of a very low density lipoprotein subpopulation from familial dysbetalipoproteinemia to in vitro lipolytic conversion to the low density lipoprotein density fraction.

Journal of Lipid Research, 1983
In vitro lipolysis of very low density lipoprotein (VLDL) from normolipidemic and familial dysbetalipoproteinemic plasma by purified bovine milk lipoprotein lipase was studied using the combined single vertical spin and vertical autoprofile method of ...
B H Chung, J P Segrest
doaj  

Cross‐sectional and longitudinal metabolomics‐based profiles associated with oral contraceptive and progestin‐only pill use: A Finnish population‐based study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In a metabolomics study of over 200 metabolites in 1721 fertile‐aged women, we found that current use of combined oral contraceptives (COC), especially third‐generation and other COCs, is associated with altered levels of several metabolic measures compared to nonuse of hormonal contraception or to use of a levonorgestrel intrauterine device (LNG‐IUD).
Elena Toffol, Jari Haukka, Pekka Jousilahti, Lara Lehtoranta, Anni Joensuu, Timo Partonen, Iris Erlund, Oskari Heikinheimo   +7 more
wiley   +1 more source

Hepatitis C virus and lipid metabolism: their implications in vaccine development and treatment

Biotecnología Aplicada
The hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of chronic hepatitis and severe forms of liver damage as cirrhosis and hepatocellular carcinoma.
Santiago Dueñas-Carrera
doaj  

Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model

British Journal of Pharmacology, EarlyView.
Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens, Na Zhan, Sammie C. Yam, Marcella Palumbo, Lorenzo Pontini, Frank P. J. Leijten, Leonie van Vark‐van der Zee, Gardi Voortman, Silvia Friedrichs, Albert Gerding, Maura Marinozzi, Johan W. Jonker, Folkert Kuipers, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder   +15 more
wiley   +1 more source

Familial LCAT Deficiency and Low HDL-C Levels: In silico Characterization of Two Rare LCAT Missense Mutations

The Application of Clinical Genetics
Sebastian Ciro Acosta,1 Lorena Díaz-Ordóñez,1,2 Juan David Gutierrez-Medina,1,3 Yisther Katherine Silva-Cuero,1,2 Luis Guillermo Arango-Vélez,4,5 Andrés Octavio García-Trujillo,4,5 Harry Pachajoa1,2,6 1Centro de Investigaciones en Anomalias Congenitas y ...
Ciro Acosta S, Díaz-Ordóñez L, Gutierrez-Medina JD, Silva-Cuero YK, Arango-Vélez LG, García-Trujillo AO, Pachajoa H   +6 more
doaj  

Plasma lipoprotein metabolism in lean and in fat chickens produced by divergent selection for plasma very low density lipoprotein concentration.

Journal of Lipid Research, 1989
Plasma lipoprotein metabolism was studied in vivo in two lines of chickens produced by selection for high and low plasma very low density lipoprotein (VLDL) concentration.
H Griffin, F Acamovic, K Guo, J Peddie
doaj  

Basal and Insulin Mediated VLDL-Triglyceride Kinetics in Type 2 Diabetic Men

Diabetes, 2010
OBJECTIVE Increased very-low-density lipoprotein triglycerides (VLDL-TG) concentration is a central feature of diabetic dyslipidemia. The objective was to compare basal and insulin mediated VLDL-TG kinetics, oxidation, and adipose tissue storage in type ...
L. Sørensen, Iben R Andersen, E. Søndergaard, L. Gormsen, O. Schmitz, J. Christiansen, S. Nielsen   +6 more
semanticscholar   +1 more source

Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals

Cell Proliferation, EarlyView.
One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye, Yanlin Li, Xiaolin Yang, Chenglin Li, Rui Yu, Guangjuan Zheng, Zuqing Su   +6 more
wiley   +1 more source