Results 81 to 90 of about 59,863 (274)

Effect of niacin on VLDL production and clearance.

, 2013
To determine VLDL production, mice were injected with Trans35S label and tyloxapol and the accumulation of TG in plasma (A) and the production rate of VLDL-TG and apoB, as well as VLDL lipidation, defined as the ratio of VLDL-TG/apoB, were determined (B).
Elsbet J. Pieterman (423757), Johannes W. A. Smit (106712), Louis M. Havekes (123558), Jan B. van Klinken (423758), Mattijs M. Heemskerk (423756), J. Wouter Jukema (127361), Susan Kühnast (423754), Hans M. G. Princen (423760), Mieke C. Louwe (423755), Patrick C. N. Rensen (123564), Sjoerd A. A. van den Berg (166384), José W. A. van der Hoorn (423759)   +11 more
core   +1 more source

Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein (VLDL)

, 2022
Embraced with apolipoproteins (Apo) B and Apo E, triglyceride-enriched very-low-density lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours.
Hsiang-Chun Lee, Jih-Kai Huang
core   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Interrelationship between rat serum very low density and high density lipoproteins

Journal of Lipid Research, 1972
An exchange of phospholipids and certain peptides among various classes of rat serum lipoproteins has been demonstrated and its nature has been investigated.
Bernard Rubenstein, David Rubinstein
doaj   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Apolipoprotein E enhances lipid exchange between lipoproteins mediated by cholesteryl ester transfer protein.

Journal of Lipid Research, 1993
The direct effect of apolipoprotein (apo) E on cholesteryl ester transfer protein (CETP) activity was studied using lipoproteins from a subject with apoE deficiency (Atherosclerosis. 1991. 88: 15-20) as a model system.
M Kinoshita, H Arai, M Fukasawa, T Watanabe, K Tsukamoto, Y Hashimoto, K Inoue, K Kurokawa, T Teramoto   +8 more
doaj   +1 more source

MicroRNA‐Mediated Autophagy and Cardiovascular Diseases: Exploring the Crossroads of Atherosclerosis and Beyond

Journal of Clinical Laboratory Analysis, EarlyView.
This graphical abstract illustrates the dynamic bidirectional crosstalk between microRNA biogenesis and autophagy, which serves as a critical regulatory axis in cardiovascular homeostasis. We highlight how specific miRNAs modulate autophagic flux to mitigate vascular inflammation and plaque instability, while concurrently, the autophagic machinery ...
Sepehr Ebrahimi‐Dehkordi, Amir Hossein Barjasteh, Aida Zarei, Sina Bazmi, Sarah Vaseghi, Sara Ashna, Amirreza Solati, Ali Yousefzadeh, Bita Safarzadeh Nasrabad, Zahra Mohammadi, Hamed Haddad Kashani, Mohammad Hossein Pourhanifeh   +11 more
wiley   +1 more source

VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation

Journal of Lipid Research, 2010
Our previous work indicated that apolipoprotein (apo) E4 assumes a more expanded conformation in the postprandial period. The postprandial state is characterized by increased VLDL lipolysis.
Sarada D. Tetali, Madhu S. Budamagunta, Catalina Simion, Laura J. den Hartigh, Tamás Kálai, Kálmán Hideg, Danny M. Hatters, Karl H. Weisgraber, John C. Voss, John C. Rutledge   +9 more
doaj   +1 more source

A history of previous gestational diabetes mellitus is associated with adverse changes in insulin secretion and VLDL metabolism independently of increased intrahepatocellular lipid

, 2013
<p>Aims/hypothesis: We have previously reported a high prevalence of non-alcoholic fatty liver disease (NAFLD) among women with previous gestational diabetes mellitus (pGDM). We wanted to confirm that intrahepatocellular lipid (IHCL) is associated
Taylor-Robinson, S.D., Walker, B.R., Godsland, I.F., Hamilton, G., Thomas, E.L., Parker, K.H., Johnston, D. G., Walker, B. R., Bedford, D.C., Bell, J.D., Bedford, D., Johnston, D.G., Marshall, I., Patel, N., Forbes, S., Caslake, M., Gray, C.D.   +16 more
core   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source