Results 61 to 70 of about 63,187 (253)

Hepatic apolipoprotein E expression promotes very low density lipoprotein-apolipoprotein B production in vivo in mice

Journal of Lipid Research, 2000
In addition to its role in the uptake of apolipoprotein B (apoB)-containing lipoproteins, apoE promotes hepatic very low density lipoprotein-triglyceride (VLDL-TG) production in animal models.
Cyrille Maugeais, Uwe J.F. Tietge, Kazuhisa Tsukamoto, Jane M. Glick, Daniel J. Rader   +4 more
doaj   +1 more source

LDL, scavenger, and beta-VLDL receptors on aortic endothelial cells.

, 1984
Primary and first passage aortic endothelial cells were shown to possess a high affinity receptor for beta-migrating very low density lipoproteins (beta-VLDL) distinct from the low density lipoprotein (LDL) receptor and scavenger receptor on these cells.
P A Edwards, A M Fogelman, J A Berliner, B J Van Lenten, D P Baker, C Kean   +5 more
core   +1 more source

A novel role for CD36 in VLDL-enhanced platelet activation [PDF]

, 2003
Type 2 diabetes is characterized by increased plasma triglyceride levels and a fourfold increase in ischemic heart disease, but the mechanism is unclear. CD36 is a receptor/transporter that binds fatty acids of lipoproteins.
Aitman, T.J., Baglin, T.P., T. P. Baglin, N. A. Englyst, J. M. Taube, Byrne, C.D., Englyst, N.A., T. J. Aitman, Taube, J.M., C. D. Byrne   +9 more
core   +1 more source

Effect of apolipoprotein E genotype on apolipoprotein B-100 metabolism in normolipidemic and hyperlipidemic subjects

Journal of Lipid Research, 2010
The effect of apolipoprotein (apo) E genotype on apoB-100 metabolism was examined in three normolipidemic apoE2/E2, five type III hyperlipidemic apoE2/E2, and five hyperlipidemic apoE3/E2 subjects using simultaneous administration of 131I-VLDL and 125I ...
Esther M.M. Ooi, Edward D. Janus, Susan J. Grant, Lucia M.T. Sinclair, P. Hugh R.Barrett   +4 more
doaj   +1 more source

Hepatic perfusate very low density lipoproteins obtained from fat-fed nonhuman primates stimulate cholesterol esterification in macrophages.

Journal of Lipid Research, 1988
The livers of both baboons and rhesus monkeys fed a high fat, high cholesterol diet secreted very low density lipoproteins (VLDL) that were enriched in cholesteryl ester and apoe as compared to VLDL secreted by the livers of chow-fed animals. Stimulation
P A Soltys, H Gump, L Hennessy, T Mazzone, K D Carey, H C McGill, Jr, G S Getz, S R Bates   +7 more
doaj   +1 more source

GLP-1 receptor agonism reduces hepatic VLDL-TG and VLDL-apoB production without affecting VLDL particle composition.

, 2012
E3L mice were fed a HFD for 22 weeks. The last 4 weeks, mice were treated with either vehicle (HFD control), CNTO3649 (1.0 or 3.0 mg/kg/day) or exendin-4 (15 or 50 μg/kg/day).
Johannes A. Romijn (123559), Hanno Pijl (123561), Janine J. Geerling (123550), Kristen Picha (38996), Louis M. Havekes (123558), Tatiana Ort (123557), Janny P. Schröder-Van der Elst (123552), Edwin T. Parlevliet (123546), Yanan Wang (123548), Vedrana Stojanovic-Susulic (123556), Patrick C. N. Rensen (123564), Karyn O'Neil (123554)   +11 more
core   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDLs⃞

Journal of Lipid Research, 2007
Withdrawing growth factors or serum from endothelial cells leads to the activation of effector caspases 3 and 7, resulting in apoptotic cell death. HDL protects against caspase induction through sphingosine-1-phosphate (S1P) receptors.
Mirta Mihovilovic, Jennifer B. Robinette, Robert M. DeKroon, Patrick M. Sullivan, Warren J. Strittmatter   +4 more
doaj   +1 more source

Hepatocyte‐Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies

iNew Medicine, EarlyView.
This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley   +1 more source

Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E[S]

Journal of Lipid Research, 2017
Cholesteryl ester transfer protein (CETP) mediates the transfer of HDL cholesteryl esters for triglyceride (TG) in VLDL/LDL. CETP inhibition, with anacetrapib, increases HDL-cholesterol, reduces LDL-cholesterol, and lowers TG levels. This study describes
John S. Millar, Michael E. Lassman, Tiffany Thomas, Rajasekhar Ramakrishnan, Patricia Jumes, Richard L. Dunbar, Emil M. deGoma, Amanda L. Baer, Wahida Karmally, Daniel S. Donovan, Hashmi Rafeek, John A. Wagner, Stephen Holleran, Joseph Obunike, Yang Liu, Soumia Aoujil, Taylor Standiford, David E. Gutstein, Henry N. Ginsberg, Daniel J. Rader, Gissette Reyes-Soffer   +20 more
doaj   +1 more source