Results 91 to 100 of about 63,187 (253)

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Familial LCAT Deficiency and Low HDL-C Levels: In silico Characterization of Two Rare LCAT Missense Mutations

The Application of Clinical Genetics
Sebastian Ciro Acosta,1 Lorena Díaz-Ordóñez,1,2 Juan David Gutierrez-Medina,1,3 Yisther Katherine Silva-Cuero,1,2 Luis Guillermo Arango-Vélez,4,5 Andrés Octavio García-Trujillo,4,5 Harry Pachajoa1,2,6 1Centro de Investigaciones en Anomalias Congenitas y ...
Ciro Acosta S, Díaz-Ordóñez L, Gutierrez-Medina JD, Silva-Cuero YK, Arango-Vélez LG, García-Trujillo AO, Pachajoa H   +6 more
doaj  

Studies on the metabolism of apolipoprotein B in hypertriglyceridemic subjects using simultaneous administration of tritiated leucine and radioiodinated very low density lipoprotein.

Journal of Lipid Research, 1990
To study the metabolic pathways of apolipoprotein B (apoB), a series of studies were carried out in which both radioiodinated very low density lipoproteins (VLDL) and tritiated leucine were simultaneously injected into three hypertriglyceridemic subjects.
WF Beltz, YA Kesäniemi, NH Miller, WR Fisher, SM Grundy, LA Zech   +5 more
doaj   +1 more source

Ein neuer Stoffwechselweg zur Synthese von VLDL in der Mausleber

, 2006
Es wird davon ausgegangen, dass LDL von der Leber und von peripheren Zellen endozytiert und vollständig abgebaut wird.
Mleczko, Anna, Wimmer, Ernst A., Figura, Kurt von, Georg-August-Universität Göttingen, null null, Anna Mleczko   +5 more
core   +1 more source

Efficacy and Safety of CagriSema in Type 2 Diabetes: A Dose‐ and Comparator‐Specific Systematic Review and Bayesian Meta‐Analysis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background CagriSema combines cagrilintide with semaglutide and may improve glycaemic control and body weight in Type 2 diabetes. We evaluated its dose‐ and comparator‐specific efficacy and safety. Methods PubMed, Embase, CENTRAL and ClinicalTrials.gov were searched through 30 June 2026 for randomized controlled trials.
Chia Siang Kow, Abdullah Faiz Zaihan, Dinesh Sangarran Ramachandram, Kaeshaelya Thiruchelvam   +3 more
wiley   +1 more source

Altered apolipoprotein B metabolism in very low density lipoprotein from lovastatin-treated guinea pigs.

Journal of Lipid Research, 1994
Previous studies have shown that treatment of guinea pigs with lovastatin alters the composition and the metabolic properties of circulating low density lipoprotein (LDL).
L F Berglund, W F Beltz, R L Elam, J L Witztum   +3 more
doaj   +1 more source

Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism

The FEBS Journal, EarlyView.
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney, James Griffin, Nouf Khan, Balnur Ibrash, Matthew J. O'Connor, Tomas Venit, Elizabeth Mayela Ambrosio, Spiros A. Pergantis, Elke Ober, Piergiorgio Percipalle, Kirsten C. Sadler   +10 more
wiley   +1 more source

Effects of dietary fish oil on serum lipids and VLDL kinetics in hyperlipidemic apolipoprotein E*3-Leiden transgenic mice

Journal of Lipid Research, 1998
Studying the effects of dietary fish oil on VLDL metabolism in humans is subject to both large intra- and interindividual variability. In the present study we therefore used hyperlipidemic apolipoprotein (APO) E*3-Leiden mice, which have impaired ...
Bart J.M. van Vlijmen, Ronald P. Mensink, H. Belinda van 't Hof, Rene F.G. Offermans, Marten H. Hofker, Louis M. Havekes   +5 more
doaj   +1 more source

Effect of exogenous estrogens on catabolism of VLDL in cholesterol-fed rabbits

, 1981
To determine the metabolic mechanism of the hypolipidemic response to estrogen in cholesterol-fed rabbits, very low-density lipoprotein (VLDL) apolipoprotein B (apoB) turnover studies were conducted in cholesterol-fed animals with or without estrogen ...
R. S. Kushwaha, W. R. Hazzard
core   +1 more source

Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD [PDF]

, 2016
Context: Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis.
Thomas, EL, Jackson, NC, Cuthbertson, D.J., Umpleby, A.M., Shojaee-Moradie, F., Thomas, E.L., Wright, J., Herring, R, Barrett, M, Bell, J, Kemp, G.J., Bell, J.D., Jackson, N.C., Umpleby, M, Shojaee-Moradie, F, Barrett, M., Cuthbertson, DJ, Kemp, GJ, Wright, J, Umpleby, AM   +19 more
core   +1 more source