Results 11 to 20 of about 66,180 (284)
VLDL Biogenesis and Secretion: It Takes a Village
Circulation Research, 2023 The production and secretion of VLDLs (very-low-density lipoproteins) by hepatocytes has a direct impact on liver fat content, as well as the concentrations of cholesterol and triglycerides in the circulation and thus affects both liver and ...
W. van Zwol +3 more
semanticscholar +3 more sources
Intracellular Trafficking and Secretion of VLDL [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2012 Steady increase in the incidence of atherosclerosis is becoming a major concern not only in the United States but also in other countries. One of the major risk factors for the development of atherosclerosis is high concentrations of plasma low-density lipoprotein, which are metabolic products of very low-density lipoprotein (VLDL).
Samata Tiwari, S. Siddiqi
semanticscholar +5 more sources
Determinants of VLDL-triglycerides production
Current Opinion in Lipidology, 2012 Plasma free fatty acids (FFA) are major substrates for hepatic VLDL-triglycerides (VLDL-TG) production. In addition, it is a common belief that VLDL-TG production is a substrate driven process primarily determined by systemic FFA delivery. This review summarizes recent research of our understanding of the regulation of VLDL-TG production.Recent studies
S. Nielsen, F. Karpe
semanticscholar +6 more sources
Measuring VLDL-triglyceride turnover in humans using ex vivo-prepared VLDL tracer [PDF]
Journal of Lipid Research, 2006 There has been more interest in VLDL-triglyceride (TG) kinetics during the last decade. Unfortunately, robust measurement methods are elaborate and not readily available.
Lars C. Gormsen +2 more
doaj +6 more sources
Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein (VLDL)
International Journal of Molecular Sciences, 2022 Embraced with apolipoproteins (Apo) B and Apo E, triglyceride-enriched very-low-density lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours.
Jih-Kai Huang, Hsiang-Chun Lee
semanticscholar +1 more source
Expression of the VLDL Receptor in Endothelial Cells [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 1996 Abstract In this article we describe the cellular distribution of the very low density lipoprotein receptor (VLDLR), a transmembrane protein that is expressed at high concentrations in skeletal muscle, heart, adipose tissue, and brain but in only trace amounts in the liver.
Kathleen Wyne +3 more
openalex +4 more sources
Reproducibility of stable isotope-labeled tracer measures of VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics [PDF]
Journal of Lipid Research, 2007 To gain insight into the mechanisms regulating plasma lipid homeostasis, FFA, VLDL-triglyceride (TG), and VLDL-apolipoprotein B-100 (apoB-100) kinetics are commonly assessed using stable isotope-labeled tracer methods.
Magkos Faidon +2 more
doaj +4 more sources
Journal of Lipid Research, 2020 Angiopoietin-like protein (ANGPTL)3 regulates plasma lipids by inhibiting LPL and endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical LDLR-mediated pathway and represents a promising therapeutic approach for ...
Rene C. Adam +15 more
semanticscholar +1 more source
Theranostics, 2020 Rationale: Men and postmenopausal women are more prone to developing non-alcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) than premenopausal women.
Meng Yang +11 more
semanticscholar +1 more source
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
wiley +1 more source