Results 21 to 30 of about 59,863 (274)

α-Tocopherol Reduces VLDL Secretion through Modulation of Intracellular ER-to-Golgi Transport of VLDL [PDF]

, 2023
Avoiding hepatic steatosis is crucial for preventing liver dysfunction, and one mechanism by which this is accomplished is through synchronization of the rate of very low-density lipoprotein (VLDL) synthesis with its secretion.
Ryan Clay, Clay, Ryan, Siddiqi, Shadab A., Shaila Siddiqi, Siddiqi, Shaila, Shadab A. Siddiqi   +5 more
core   +1 more source

Cholesterol Content of Very-Low-Density Lipoproteins Is Associated with 1-Year Mortality in Acute Heart Failure Patients

Biomolecules, 2022
Considering the relationship between the extent of metabolic derangement and the disease severity in heart failure, we hypothesized that the lipid content of very-low-density lipoprotein (VLDL) may have prognostic value for 1 year mortality in acute ...
Vesna Degoricija, Iva Klobučar, Ines Potočnjak, Sanda Dokoza Terešak, Luka Vidović, Gudrun Pregartner, Andrea Berghold, Hansjörg Habisch, Tobias Madl, Saša Frank   +9 more
doaj   +1 more source

Study of lipid profile for psoriatic patients in AL-Anbar governorate. [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2014
Psoriasis is a chronic inflammatory skin condition which affects approximately 1-3% of the world's population (1). It appears as red plaques covered with silvery scale that flakes away from the skin.Psoriatic plaques are often found on the elbows, scalp ...
Wajeeh Y. Mohammed, Abdullah S. Al-Hasan, Ausama A. Faisal   +2 more
doaj   +1 more source

VLDL-TG secretion in Lipg^-/- mice.

, 2021
A. Plasma triglycerides in mice at the indicated timepoints following intraperitoneal injection of poloxamer P407, a competitive inhibitor of LPL activity. Plasma TGs were measured by colorimetric biochemical assays. B. VLDL-TG secretion rates calculated
Papasani V. Subbaiah (232673), Daniel J. Rader (7658096), Takashi Kuwano (8746116), Derek Klarin (2079340), Dhavamani Sugasini (4579258), Cecilia Vitali (2503018), Michael G. Levin (9499397), Akhil Pampana (11457970), Jeffrey T. Billheimer (11457976), Sumeet A. Khetarpal (11457967), Pradeep Natarajan (819434), John S. Millar (11457973), Joseph Park (2032012)   +12 more
core   +1 more source

Using total plasma triacylglycerol to assess hepatic de novo lipogenesis as an alternative to VLDL triacylglycerol

Upsala Journal of Medical Sciences, 2020
Background: Hepatic de novo lipogenesis (DNL) is ideally measured in very low-density lipoprotein (VLDL)-triacylglycerol (TAG). In the fasting state, the majority of plasma TAG typically represents VLDL-TAG; however, the merits of measuring DNL in total ...
Leanne Hodson, Sion A. Parry, Thomas Cornfield, Catriona Charlton, Wee Suan Low, Charlotte J. Green, Fredrik Rosqvist   +6 more
doaj   +1 more source

Intracellular transports and atherogenesis

Frontiers in Bioscience-Landmark, 2020
There is a great progress in understanding the cellular and molecular aspects of atherosclerosis, which is one of the leading causes of death. Yet, there are questions regarding the cellular and metabolic mechanisms that lead to atherogenesis.
Alexander A. Mirоnоv, Irina S. Sesorova, Ivan D. Dimov, Natalia R. Karelina, Galina V. Beznoussenko   +4 more
doaj   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Exercise training reduces liver fat and increases rates of VLDL clearance but not VLDL production in NAFLD [PDF]

, 2016
Context: Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis.
Thomas, EL, Jackson, NC, Cuthbertson, D.J., Umpleby, A.M., Shojaee-Moradie, F., Thomas, E.L., Wright, J., Herring, R, Barrett, M, Bell, J, Kemp, G.J., Bell, J.D., Jackson, N.C., Umpleby, M, Shojaee-Moradie, F, Barrett, M., Cuthbertson, DJ, Kemp, GJ, Wright, J, Umpleby, AM   +19 more
core   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source